Hs00152937_m1

• Gene Symbol: TLR4
• Gene Name: toll like receptor 4
• Gene Aliases: ARMD10, CD284, TLR-4, TOLL
• Chromosome Location: Chr.9: 117704175 - 117717491 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: TLR4
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_003266.3	NP_003257.1	1 - 2	386		68
GenBank mRNA	AK226155.1	-	1 - 2	141		68
	AK290053.1	-	1 - 2	369		68
	AL710219.1	-	1 - 2	236		68
	BC143841.1	-	1 - 2	108		68
	U88880.1	-	1 - 2	132		68

More Information

Updated Mapping Information

This assay targets the same location as Clariom D transcript cluster(s) TC0900008587.hg.1
This assay targets the same location as HTA transcript cluster(s) TC09000601.hg.1

Additional Information:

This assay is in the 5'UTR region of the AK290053.1,NM_003266.3,U88880.1 transcripts.

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Mammalian Gene Collection, Homo sapiens, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene TLR4

Gene Ontology Categories:

Process(es)

activation of MAPK activity
toll-like receptor signaling pathway
B cell proliferation involved in immune response
nitric oxide production involved in inflammatory response
regulation of dendritic cell cytokine production
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
inflammatory response
immune response
I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation
positive regulation of platelet activation
positive regulation of gene expression
astrocyte development
detection of fungus
positive regulation of B cell proliferation
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
detection of lipopolysaccharide
interferon-gamma production
negative regulation of interferon-gamma production
negative regulation of interleukin-17 production
negative regulation of interleukin-23 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
negative regulation of MyD88-independent toll-like receptor signaling pathway
toll-like receptor 4 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
T-helper 1 type immune response
macrophage activation
positive regulation of NF-kappaB import into nucleus
positive regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
positive regulation of interleukin-12 biosynthetic process
innate immune response
positive regulation of MHC class II biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interleukin-8 biosynthetic process
positive regulation of nitric oxide biosynthetic process
negative regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
interleukin-1 beta secretion
regulation of cytokine secretion
positive regulation of inflammatory response
defense response to Gram-negative bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
intestinal epithelial structure maintenance
positive regulation of macrophage cytokine production
necroptotic process
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
cellular response to mechanical stimulus
apoptotic signaling pathway
positive regulation of NLRP3 inflammasome complex assembly

Function(s)

lipopolysaccharide binding
lipopolysaccharide receptor activity
receptor activity
transmembrane signaling receptor activity
protein binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	PSR09006792.hg.1	TC09000601.hg.1	HTA TC
Affymetrix Human Transcriptome Array 2.0	PSR09006792.hg.1	ENST00000394487.4	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR09006792.hg.1	NM_003266.3	Refseq
Affymetrix Human Clariom D Assay	PSR0900157287.hg.1	ENST00000394487.4	Ensembl
Affymetrix Human Clariom D Assay	PSR0900157287.hg.1	ENST00000490685.1	Ensembl
Affymetrix Human Clariom D Assay	PSR0900157287.hg.1	NM_003266.3	Refseq
Affymetrix Human Clariom D Assay	PSR0900157287.hg.1	ENST00000394487.4	Ensembl
Affymetrix Human Clariom D Assay	PSR0900157287.hg.1	ENST00000490685.1	Ensembl
Affymetrix Human Clariom D Assay	PSR0900157287.hg.1	NM_003266.3	Refseq
Affymetrix Human Clariom D Assay	PSR0900157287.hg.1	TC0900008587.hg.1	Clariom D TC