Hs00172783_m1

• Gene Symbol: EZH2
• Gene Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
• Gene Aliases: ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2
• Chromosome Location: Chr.7: 148807372 - 148884662 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: EZH2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001203247.1	NP_001190176.1	4 - 5	558		137
	NM_001203248.1	NP_001190177.1	4 - 5	531		137
	NM_001203249.1	NP_001190178.1	4 - 5	658		137
	NM_004456.4	NP_004447.2	4 - 5	558		137
	XM_005249962.4	XP_005250019.1	4 - 5	2999		137
	XM_005249963.4	XP_005250020.1	4 - 5	2972		137
	XM_005249964.4	XP_005250021.1	4 - 5	2973		137
	XM_011515883.2	XP_011514185.1	5 - 6	533		137
	XM_011515884.2	XP_011514186.1	4 - 5	665		137
	XM_011515885.2	XP_011514187.1	4 - 5	2974		137
	XM_011515886.2	XP_011514188.1	5 - 6	682		137
	XM_011515887.2	XP_011514189.1	4 - 5	531		137
	XM_011515888.2	XP_011514190.1	4 - 5	653		137
	XM_011515889.2	XP_011514191.1	4 - 5	455		137
	XM_011515891.2	XP_011514193.1	2 - 3	618		137
	XM_011515892.2	XP_011514194.1	4 - 5	3002		137
	XM_011515897.2	XP_011514199.1	5 - 6	709		137
	XM_011515898.2	XP_011514200.1	5 - 6	636		137
	XM_011515899.2	XP_011514201.1	4 - 5	3004		137
	XM_011515901.2	XP_011514203.1	4 - 5	3004		137
	XM_017011817.1	XP_016867306.1	4 - 5	3000		137
	XM_017011818.1	XP_016867307.1	5 - 6	682		137
	XM_017011819.1	XP_016867308.1	4 - 5	3000		137
	XM_017011821.1	XP_016867310.1	5 - 6	709		137
GenBank mRNA	AB208895.1	-	4 - 5	492		137
	AK293239.1	-	4 - 5	469		137
	AK302216.1	-	4 - 5	658		137
	AK303585.1	-	4 - 5	496		137
	AK303637.1	-	5 - 6	710		137
	AY519465.1	-	3 - 4	365		137
	BC010858.2	-	4 - 5	487	3901250	137
	BG829016.1	-	4 - 5	532		138
	U61145.1	-	4 - 5	454		137
	X95653.1	-	4 - 5	422		137

More Information

Additional Information:

This assay is in the 5'UTR region of the AK303637.1, XM_011515897.2, XM_011515898.2, XM_017011821.1 transcripts.

• Set Membership: Ambion siRNA available, Amplicon length greater than or equal to 101, Mammalian Gene Collection, Homo sapiens, Inventoried, MicroArray Quality Control (MAQC), Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene EZH2

Panther Classification:

Molecular Function -

histone modifying enzyme

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
DNA methylation
chromatin organization
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of epithelial to mesenchymal transition
regulation of gliogenesis
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
cerebellar cortex development
hippocampus development
response to estradiol
negative regulation of transcription elongation from RNA polymerase II promoter
regulation of cell proliferation
regulation of circadian rhythm
positive regulation of MAP kinase activity
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of GTPase activity
negative regulation of epidermal cell differentiation
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
negative regulation of retinoic acid receptor signaling pathway
rhythmic process
negative regulation of striated muscle cell differentiation
cellular response to hydrogen peroxide
G1 to G0 transition
histone H3-K27 methylation
protein localization to chromatin
positive regulation of protein serine/threonine kinase activity
positive regulation of dendrite development
negative regulation of G1/S transition of mitotic cell cycle

Function(s)

core promoter binding
DNA binding
chromatin binding
RNA binding
protein binding
protein-lysine N-methyltransferase activity
histone-lysine N-methyltransferase activity
chromatin DNA binding
histone methyltransferase activity
ribonucleoprotein complex binding
sequence-specific DNA binding
histone methyltransferase activity (H3-K27 specific)
promoter-specific chromatin binding