Assay Details

Gene Symbol: IL10
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_000572.2	NP_000563.1	3 - 4	441		119
GenBank mRNA	AF043333.1	-	3 - 4	328		119
	AY029171.1	-	3 - 4	382		119
	BC104252.1	-	3 - 4	438	40035920	119
	BC104253.1	-	3 - 4	438	40035922	119
	CR541993.1	-	3 - 4	382		119
	M57627.1	-	3 - 4	412		119

More Information

Updated Mapping Information

This assay targets the same location as Clariom D transcript cluster(s) TC0100017107.hg.1
This assay targets the same location as HTA transcript cluster(s) TC01003766.hg.1

Set Membership:

Ambion siRNA available

Amplicon length greater than or equal to 101

Apoptosis

Immune Tolerance Network

Mammalian Gene Collection

Homo sapiens

Human Chemokine Panel

Human Immune Response

Human NFkB Pathway

Human Diabetes

Inventoried

Human_Immune

Human_Nfkb

Human_Diabetes

Human_Chemokine

Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene IL10

Gene Ontology Categories:

Function(s) Process(es)

MicroArray Probes:

Affymetrix

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	PSR01057741.hg.1	TC01003766.hg.1	HTA TC
Affymetrix Human Transcriptome Array 2.0	PSR01057741.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR01057741.hg.1	ENST00000471071.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR01057741.hg.1	NM_000572.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000367099.3	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000367099.3	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000367099.3	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000367099.3	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000471071.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000471071.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000471071.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	ENST00000471071.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	PSR0100229692.hg.1	ENST00000367099.3	Ensembl
Affymetrix Human Clariom D Assay	PSR0100229692.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	PSR0100229692.hg.1	ENST00000471071.1	Ensembl
Affymetrix Human Clariom D Assay	PSR0100229692.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	PSR0100229692.hg.1	ENST00000367099.3	Ensembl
Affymetrix Human Clariom D Assay	PSR0100229692.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	PSR0100229692.hg.1	ENST00000471071.1	Ensembl
Affymetrix Human Clariom D Assay	PSR0100229692.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	PSR0100229692.hg.1	TC0100017107.hg.1	Clariom D TC
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000367099.3	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000367099.3	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000367099.3	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000367099.3	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000423557.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000471071.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000471071.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000471071.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	ENST00000471071.1	Ensembl
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	NM_000572.2	Refseq
Affymetrix Human Clariom D Assay	TC0100017107.hg.1	NM_000572.2	Refseq

Citations (29)

The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro.

Authors: Scholz H, Lund T, Dahle MK, Collins JL, Korsgren O, Wang JE, Foss A
Journal: Diabetologia - Page No 1352 (Wed Jul 01 00:00:00 EDT 2009)
Volume (Year): 52 (2009)
Product Usage: -

Intragraft expression of the IL-10 gene is up-regulated in renal protocol biopsies with early interstitial fibrosis, tubular atrophy, and subclinical rejection.

Authors: Hueso M, Navarro E, Moreso F, O'Valle F, Perez-Riba M, Del Moral RG, Grinyo JM, Seron D
Journal: Am J Pathol - Page No 1696 (Thu Apr 01 00:00:00 EDT 2010)
Volume (Year): 176 (2010)
Product Usage: -

Hypercytokinaemia accompanies HIV-tuberculosis immune reconstitution inflammatory syndrome.

Authors: Tadokera R, Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Seldon R, Chegou NN, Maartens G, Rangaka MX, Rebe K, Walzl G, Wilkinson RJ
Journal: Eur Respir J - Page No (Fri Sep 03 00:00:00 EDT 2010)
Volume (Year): (2010)
Product Usage: -

Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells.

Authors: Makela SM, Strengell M, Pietila TE, Osterlund P, Julkunen I
Journal: J Leukoc Biol - Page No 664 (Wed Apr 01 00:00:00 EDT 2009)
Volume (Year): 85 (2009)
Product Usage: -

Differential effects of HIV type 1 clade B and clade C Tat protein on expression of proinflammatory and antiinflammatory cytokines by primary monocytes.

Authors: Gandhi N, Saiyed Z, Thangavel S, Rodriguez J, Rao KV, Nair MP
Journal: Aids Res Hum Retroviruses - Page No 691 (Wed Jul 01 00:00:00 EDT 2009)
Volume (Year): 25 (2009)
Product Usage: -

Inflammatory and microRNA Gene Expression as Prognostic Classifiers of Barrett's Associated Esophageal Adenocarcinoma.

Authors: Nguyen GH, Schetter AJ, Chou DB, Bowman ED, Zhao R, Hawkes JE, Mathe E, Kumamoto K, Zhao Y, Budhu A, Hagiwara N, Wang XW, Miyashita M, Casson AG, Harris CC
Journal: Clin Cancer Res - Page No (Mon Oct 25 00:00:00 EDT 2010)
Volume (Year): (2010)
Product Usage: -

Remodeling phenotype of human subcutaneous adipose tissue macrophages.

Authors: Bourlier V, Zakaroff-Girard A, Miranville A, De Barros S, Maumus M, Sengenes C, Galitzky J, Lafontan M, Karpe F, Frayn KN, Bouloumie A
Journal: Circulation - Page No 806 (Tue Feb 12 00:00:00 EST 2008)
Volume (Year): 117 (2008)
Product Usage: -

Role of the mTOR Pathway in LPS-Activated Monocytes: Influence of Hypertonic Saline.

Authors: Schaeffer V, Arbabi S, Garcia IA, Knoll ML, Cuschieri J, Bulger EM, Maier RV
Journal: J Surg Res - Page No (Wed Jun 09 00:00:00 EDT 2010)
Volume (Year): (2010)
Product Usage: -

New means to monitor the effect of glucocorticoid therapy in children.

Authors: Rintamaki H, Salo HM, Vaarala O, Kolho KL
Journal: World J Gastroenterol - Page No 1104 (Sun Mar 07 00:00:00 EST 2010)
Volume (Year): 16 (2010)
Product Usage: -

cis-Urocanic acid initiates gene transcription in primary human keratinocytes.

Authors: Kaneko K, Smetana-Just U, Matsui M, Young AR, John S, Norval M, Walker SL
Journal: J Immunol - Page No 217 (Tue Jul 01 00:00:00 EDT 2008)
Volume (Year): 181 (2008)
Product Usage: -

CRH mediates inflammation induced by lipopolysaccharide in human adult epidermal keratinocytes.

Authors: Zbytek B, Slominski AT
Journal: J Invest Dermatol - Page No 730 (Thu Mar 01 00:00:00 EST 2007)
Volume (Year): 127 (2007)
Product Usage: -

Differential expression patterns of cytokines in complex regional pain syndrome.

Authors: Uceyler N, Eberle T, Rolke R, Birklein F, Sommer C
Journal: Pain - Page No 195 (Thu Nov 01 00:00:00 EDT 2007)
Volume (Year): 132 (2007)
Product Usage: -

Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation.

Authors: Vlad G, Ho EK, Vasilescu ER, Fan J, Liu Z, Cai JW, Jin Z, Burke E, Deng M, Cadeiras M, Cortesini R, Itescu S, Marboe C, Mancini D, Suciu-Foca N
Journal: Transpl Immunol - Page No 13 (Sun Jul 01 00:00:00 EDT 2007)
Volume (Year): 18 (2007)
Product Usage: -

Intragraft FOXP3 mRNA expression reflects antidonor immune reactivity in cardiac allograft patients.

Authors: Dijke IE, Velthuis JH, Caliskan K, Korevaar SS, Maat AP, Zondervan PE, Balk AH, Weimar W, Baan CC
Journal: Transplantation - Page No 1477 (Fri Jun 15 00:00:00 EDT 2007)
Volume (Year): 83 (2007)
Product Usage: -

Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients.

Authors: Suciu-Foca N, Feirt N, Zhang QY, Vlad G, Liu Z, Lin H, Chang CC, Ho EK, Colovai AI, Kaufman H, D'Agati VD, Thaker HM, Remotti H, Galluzzo S, Cinti P, Rabitti C, Allendorf J, Chabot J, Caricato M, Coppola R, Berloco P, Cortesini R
Journal: J Immunol - Page No 7432 (Fri Jun 01 00:00:00 EDT 2007)
Volume (Year): 178 (2007)
Product Usage: -

Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia.

Authors: Keller CC, Yamo O, Ouma C, Ong'echa JM, Ounah D, Hittner JB, Vulule JM, Perkins DJ
Journal: Infect Immun - Page No 5249 (Fri Sep 01 00:00:00 EDT 2006)
Volume (Year): 74 (2006)
Product Usage: -

Postmenopausal expression changes of immune system-related genes in human bone tissue.

Authors: Kosa JP, Balla B, Kiss J, Podani J, Takacs I, Lazary A, Nagy Z, Bacsi K, Karsai A, Speer G, Lakatos P
Journal: J Clin Immunol - Page No 761 (Sun Nov 01 00:00:00 EDT 2009)
Volume (Year): 29 (2009)
Product Usage: -

Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression.

Authors: Cacev T, Radosevic S, Krizanac S, Kapitanovic S
Journal: Carcinogenesis - Page No 1572 (Fri Aug 01 00:00:00 EDT 2008)
Volume (Year): 29 (2008)
Product Usage: -

Molecular evidence of injury and inflammation in normal and fibrotic renal allografts one year posttransplant.

Authors: Park W, Griffin M, Grande JP, Cosio F, Stegall MD
Journal: Transplantation - Page No 1466 (Fri Jun 15 00:00:00 EDT 2007)
Volume (Year): 83 (2007)
Product Usage: -

Using distinct molecular signatures of human monocytes and dendritic cells to predict adjuvant activity and pyrogenicity of TLR agonists.

Authors: Kamgang RK, Ramos I, Rodrigues Duarte L, Ghielmetti M, Freudenberg M, Dahinden C, Padovan E
Journal: Med Microbiol Immunol - Page No 369 (Mon Dec 01 00:00:00 EST 2008)
Volume (Year): 197 (2008)
Product Usage: -

Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.

Authors: Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, Adikibi T, Pridgeon C, Dallman M, Loke TK, Robinson DS, Barrat FJ, O'Garra A, Lavender P, Lee TH, Corrigan C, Hawrylowicz CM
Journal: J Clin Invest - Page No 146 (Sun Jan 01 00:00:00 EST 2006)
Volume (Year): 116 (2006)
Product Usage: -

Effect of sialic acid loss on dendritic cell maturation.

Authors: Crespo HJ, Cabral MG, Teixeira AV, Lau JT, Trindade H, Videira PA
Journal: Immunology - Page No e621 (Tue Sep 01 00:00:00 EDT 2009)
Volume (Year): 128 (2009)
Product Usage: -

Gene expression by human monocytes from peripheral blood in response to exposure to metals.

Authors: Jost-Albrecht K, Hofstetter W
Journal: J Biomed Mater Res B Appl Biomater - Page No 449 (Wed Feb 01 00:00:00 EST 2006)
Volume (Year): 76 (2006)
Product Usage: -

Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells.

Authors: Slominski A, Zbytek B, Slominski R
Journal: Int J Cancer - Page No 1470 (Sun Mar 15 00:00:00 EDT 2009)
Volume (Year): 124 (2009)
Product Usage: -

High expression of Foxp3, IL-23p19 and survivin mRNA in colorectal carcinoma.

Authors: Stanilov N, Miteva L, Mintchev N, Stanilova S
Journal: Int J Colorectal Dis - Page No 151 (Sun Feb 01 00:00:00 EST 2009)
Volume (Year): 24 (2009)
Product Usage: -

Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide.

Authors: Barksby HE, Nile CJ, Jaedicke KM, Taylor JJ, Preshaw PM
Journal: Clin Exp Immunol - Page No 479 (Mon Jun 01 00:00:00 EDT 2009)
Volume (Year): 156 (2009)
Product Usage: -

Myeloid dendritic cells from human cutaneous squamous cell carcinoma are poor stimulators of T-cell proliferation.

Authors: Bluth MJ, Zaba LC, Moussai D, Suarez-Farinas M, Kaporis H, Fan L, Pierson KC, White TR, Pitts-Kiefer A, Fuentes-Duculan J, Guttman-Yassky E, Krueger JG, Lowes MA, Carucci JA
Journal: J Invest Dermatol - Page No 2451 (Thu Oct 01 00:00:00 EDT 2009)
Volume (Year): 129 (2009)
Product Usage: -

Increased IL-10 mRNA and IL-23 mRNA expression in multiple sclerosis: interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression.

Authors: Krakauer M, Sorensen P, Khademi M, Olsson T, Sellebjerg F
Journal: Mult Scler - Page No 622 (Sun Jun 01 00:00:00 EDT 2008)
Volume (Year): 14 (2008)
Product Usage: -

Local and systemic cytokine and chemokine responses after parenteral influenza vaccination.

Authors: Eriksson JC, Cox RJ, Szyszko E, Davidsson A, Brokstad KA
Journal: Influenza Other Respi Viruses - Page No 139 (Sun Jul 01 00:00:00 EDT 2007)
Volume (Year): 1 (2007)
Product Usage: -

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