Hs00178463_m1

• Gene Symbol: ROCK1
• Gene Name: Rho associated coiled-coil containing protein kinase 1
• Gene Aliases: P160ROCK, ROCK-I
• Chromosome Location: Chr.18: 20949740 - 21111851 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: ROCK1
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_005406.2	NP_005397.1	13 - 14	2353		121
GenBank mRNA	AB208965.1	-	5 - 6	446		121
	AK057038.1	-	13 - 14	2354		121
	AK307388.1	-	13 - 14	2168		121
	BC113114.1	-	13 - 14	1428	7961989	121
	U43195.1	-	13 - 14	1412		121

More Information

Updated Mapping Information

This assay targets the same location as Clariom D transcript cluster(s) TC1800008219.hg.1
This assay targets the same location as HTA transcript cluster(s) TC18000397.hg.1

• Set Membership: Ambion siRNA available, Amplicon length greater than or equal to 101, Protein Kinase, Mammalian Gene Collection, Homo sapiens, Human TGFB Panel, Human NGF Pathway, HUMAN PKA SIGNALING, HUMAN BREAST CANCER REGULATION BY STATHMIN1, HUMAN GPCR PATHWAY, HUMAN GUIDANCE CUES AND GROWTH CONE MOTILITY, HUMAN THROMBIN SIGNALING, HUMAN RHO FAMILY GTPASES, HUMAN RHOA PATHWAY, 1700, Inventoried, Human_NGF_Pathway, Human_TGFB, Human_Guidance_Cues_and_Growth_Cone_Motility, Human_GPCR_Pathway, Human_PKA_Signaling, Human_Thrombin_Signaling, Human_Rho_Family_GTPases, Human_RhoA_Pathway, Human_Breast_Cancer_Regulation_by_Stathmin1, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene ROCK1

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

apical constriction
protein phosphorylation
cellular component disassembly involved in execution phase of apoptosis
smooth muscle contraction
leukocyte cell-cell adhesion
signal transduction
I-kappaB kinase/NF-kappaB signaling
Rho protein signal transduction
negative regulation of angiogenesis
membrane to membrane docking
actin cytoskeleton organization
regulation of cell adhesion
cortical actin cytoskeleton organization
bleb assembly
negative regulation of protein binding
regulation of actin cytoskeleton organization
negative regulation of myosin-light-chain-phosphatase activity
negative regulation of neuron apoptotic process
regulation of keratinocyte differentiation
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
leukocyte migration
leukocyte tethering or rolling
myoblast migration
regulation of stress fiber assembly
regulation of focal adhesion assembly
positive regulation of focal adhesion assembly
establishment of protein localization to plasma membrane
regulation of establishment of endothelial barrier
negative regulation of bicellular tight junction assembly
regulation of establishment of cell polarity
regulation of cell motility

Function(s)

protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
GTP-Rho binding
metal ion binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	PSR18004082.hg.1	ENST00000399799.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR18004082.hg.1	NM_005406.2	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR18004082.hg.1	TC18000397.hg.1	HTA TC
Affymetrix Human Clariom D Assay	PSR1800156144.hg.1	ENST00000399799.2	Ensembl
Affymetrix Human Clariom D Assay	PSR1800156144.hg.1	NM_005406.2	Refseq
Affymetrix Human Clariom D Assay	PSR1800156144.hg.1	TC1800008219.hg.1	Clariom D TC
Affymetrix Human Clariom D Assay	PSR1800156144.hg.1	ENST00000399799.2	Ensembl
Affymetrix Human Clariom D Assay	PSR1800156144.hg.1	NM_005406.2	Refseq

Array Name	Probe IDs	Targets	Target Type
ABI Human Genome Survey Microarray Version 2.0	229310	-	-
ABI Human Genome Survey Microarray Version 2.0	670499	-	-