Hs00741253_m1

• Gene Symbol: PTPN2
• Gene Name: protein tyrosine phosphatase, non-receptor type 2
• Gene Aliases: PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP
• Chromosome Location: Chr.18: 12785478 - 12884351 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: PTPN2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_080423.2	NP_536348.1	8 - 9	1231		142
GenBank mRNA	BC016727.1	-	8 - 9	1143	4081330	142

More Information

Updated Mapping Information

This assay targets the same location as Clariom D transcript cluster(s) TC1800008128.hg.1
This assay targets the same location as HTA transcript cluster(s) TC18000377.hg.1

• Set Membership: Ambion siRNA available, Amplicon length greater than or equal to 101, Protein Phosphatase, 3' Most, Mammalian Gene Collection, Homo sapiens, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene PTPN2

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

negative regulation of cell proliferation
insulin receptor signaling pathway
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of lipid storage
B cell differentiation
T cell differentiation
erythrocyte differentiation
peptidyl-tyrosine dephosphorylation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of tyrosine phosphorylation of Stat1 protein
negative regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of tyrosine phosphorylation of Stat6 protein
glucose homeostasis
negative regulation of macrophage differentiation
positive regulation of gluconeogenesis
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
negative regulation of T cell receptor signaling pathway
negative regulation of chemotaxis
regulation of interferon-gamma-mediated signaling pathway
negative regulation of interferon-gamma-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
negative regulation of protein tyrosine kinase activity
negative regulation of interleukin-6-mediated signaling pathway
negative regulation of ERK1 and ERK2 cascade
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of interleukin-2-mediated signaling pathway
negative regulation of prolactin signaling pathway
negative regulation of interleukin-4-mediated signaling pathway
negative regulation of macrophage colony-stimulating factor signaling pathway
negative regulation of positive thymic T cell selection
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of PERK-mediated unfolded protein response
negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Function(s)

protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
integrin binding
protein binding
protein kinase binding
syntaxin binding
receptor tyrosine kinase binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	PSR18003967.hg.1	ENST00000327283.3	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR18003967.hg.1	ENST00000353319.3	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR18003967.hg.1	NM_001207013.1	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR18003967.hg.1	NM_080422.2	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR18003967.hg.1	NM_080423.2	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR18003967.hg.1	TC18000377.hg.1	HTA TC
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000327283.7	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000353319.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000585666.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000589444.1	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000591115.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000591901.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	NM_001207013.1	Refseq
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	NM_080422.2	Refseq
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	NM_080423.2	Refseq
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	TC1800008128.hg.1	Clariom D TC
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000327283.7	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000353319.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000585666.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000589444.1	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000591115.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	ENST00000591901.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	NM_001207013.1	Refseq
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	NM_080422.2	Refseq
Affymetrix Human Clariom D Assay	PSR1800155630.hg.1	NM_080423.2	Refseq
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000327283.7	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000353319.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000585666.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000587703.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000589444.1	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000591115.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000591901.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	NM_001207013.1	Refseq
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	NM_080422.2	Refseq
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	NM_080423.2	Refseq
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	TC1800008128.hg.1	Clariom D TC
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000327283.7	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000353319.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000585666.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000587703.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000589444.1	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000591115.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	ENST00000591901.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	NM_001207013.1	Refseq
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	NM_080422.2	Refseq
Affymetrix Human Clariom D Assay	PSR1800155631.hg.1	NM_080423.2	Refseq