Hs00892897_m1

• Gene Symbol: RYR2
• Gene Name: ryanodine receptor 2
• Gene Aliases: ARVC2, ARVD2, RYR-2, RyR, VTSIP
• Chromosome Location: Chr.1: 237042208 - 237833988 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: RYR2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001035.2	NP_001026.2	62 - 63	9138		74
	XM_006711802.3	XP_006711865.1	63 - 64	9362		74
	XM_006711803.3	XP_006711866.1	63 - 64	9359		74
	XM_006711804.3	XP_006711867.1	63 - 64	9362		74
	XM_006711805.3	XP_006711868.1	62 - 63	9332		74
	XM_006711806.3	XP_006711869.1	63 - 64	9362		74
	XM_006711807.3	XP_006711870.1	63 - 64	9362		74
	XM_006711810.3	XP_006711873.1	62 - 63	9329		74
	XM_017002028.1	XP_016857517.1	62 - 63	9341		74
GenBank mRNA	X98330.1	-	62 - 63	9139		74

More Information

Updated Mapping Information

This assay targets the same location as Clariom D transcript cluster(s) TC0100012113.hg.1
This assay targets the same location as HTA transcript cluster(s) TC01001957.hg.1

• Set Membership: Ambion siRNA available, Amplicon length between 71 and 85, Ion Channel, Homo sapiens, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene RYR2

Panther Classification:

Molecular Function -

ligand-gated ion channel

Gene Ontology Categories:

Process(es)

response to hypoxia
regulation of heart rate
embryonic heart tube morphogenesis
left ventricular cardiac muscle tissue morphogenesis
cardiac muscle hypertrophy
detection of calcium ion
calcium ion transport
cellular calcium ion homeostasis
positive regulation of heart rate
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cardiac muscle contraction by calcium ion signaling
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to muscle activity
calcium-mediated signaling
BMP signaling pathway
response to caffeine
ion transmembrane transport
calcium-mediated signaling using intracellular calcium source
response to muscle stretch
release of sequestered calcium ion into cytosol
positive regulation of sequestering of calcium ion
regulation of cytosolic calcium ion concentration
response to redox state
regulation of cardiac muscle contraction
cardiac muscle contraction
canonical Wnt signaling pathway
calcium ion transport into cytosol
sarcoplasmic reticulum calcium ion transport
cellular response to caffeine
cellular response to epinephrine stimulus
establishment of protein localization to endoplasmic reticulum
ventricular cardiac muscle cell action potential
Purkinje myocyte to ventricular cardiac muscle cell signaling
cell communication by electrical coupling involved in cardiac conduction
type B pancreatic cell apoptotic process
positive regulation of the force of heart contraction
regulation of AV node cell action potential
regulation of SA node cell action potential
regulation of atrial cardiac muscle cell action potential
regulation of ventricular cardiac muscle cell action potential
positive regulation of calcium-transporting ATPase activity
regulation of cardiac conduction

Function(s)

ryanodine-sensitive calcium-release channel activity
calcium channel activity
calcium ion binding
protein binding
calmodulin binding
calcium-release channel activity
enzyme binding
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
identical protein binding
protein self-association
suramin binding
ion channel binding
calcium-induced calcium release activity

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	PSR01030375.hg.1	TC01001957.hg.1	HTA TC
Affymetrix Human Transcriptome Array 2.0	PSR01030375.hg.1	ENST00000360064.6	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR01030375.hg.1	ENST00000366574.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR01030375.hg.1	ENST00000540213.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR01030375.hg.1	ENST00000542537.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR01030375.hg.1	NM_001035.2	Refseq
Affymetrix Human Clariom D Assay	PSR0100189266.hg.1	ENST00000360064.7	Ensembl
Affymetrix Human Clariom D Assay	PSR0100189266.hg.1	ENST00000366574.6	Ensembl
Affymetrix Human Clariom D Assay	PSR0100189266.hg.1	NM_001035.2	Refseq
Affymetrix Human Clariom D Assay	PSR0100189266.hg.1	ENST00000360064.7	Ensembl
Affymetrix Human Clariom D Assay	PSR0100189266.hg.1	ENST00000366574.6	Ensembl
Affymetrix Human Clariom D Assay	PSR0100189266.hg.1	NM_001035.2	Refseq
Affymetrix Human Clariom D Assay	PSR0100189266.hg.1	TC0100012113.hg.1	Clariom D TC