Hs00911695_m1

• Gene Symbol: KDR
• Gene Name: kinase insert domain receptor
• Gene Aliases: CD309, FLK1, VEGFR, VEGFR2
• Chromosome Location: Chr.4: 55078259 - 55125595 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: KDR
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_002253.2	NP_002244.1	22 - 23	3371		114
GenBank mRNA	AB209901.1	-	22 - 23	3356		114
	AF035121.1	-	22 - 23	3372		114
	AF063658.1	-	22 - 23	3069		114
	BC131822.1	-	22 - 23	3131	40129287	114
	L04947.1	-	22 - 23	3063		114
	X61656.1	-	22 - 23	3063		114

More Information

Updated Mapping Information

This assay targets the same location as Clariom D transcript cluster(s) TC0400010733.hg.1
This assay targets the same location as HTA transcript cluster(s) TC04001208.hg.1

• Set Membership: Ambion siRNA available, Amplicon length greater than or equal to 101, Mammalian Gene Collection, Homo sapiens, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene KDR

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

angiogenesis
vasculogenesis
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
cell migration involved in sprouting angiogenesis
endothelium development
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
regulation of cell shape
positive regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
viral process
positive regulation of macroautophagy
peptidyl-tyrosine phosphorylation
signal transduction by protein phosphorylation
extracellular matrix organization
positive regulation of cell migration
embryonic hemopoiesis
calcium-mediated signaling using intracellular calcium source
cellular response to vascular endothelial growth factor stimulus
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
peptidyl-tyrosine autophosphorylation
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of angiogenesis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
positive regulation of positive chemotaxis
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of focal adhesion assembly
positive regulation of mitochondrial depolarization
positive regulation of ERK1 and ERK2 cascade
positive regulation of mitochondrial fission
negative regulation of endothelial cell apoptotic process
positive regulation of vasculogenesis

Function(s)

protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
integrin binding
protein binding
ATP binding
growth factor binding
Hsp90 protein binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	PSR04016516.hg.1	TC04001208.hg.1	HTA TC
Affymetrix Human Transcriptome Array 2.0	PSR04016516.hg.1	ENST00000263923.4	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR04016516.hg.1	NM_002253.2	Refseq
Affymetrix Human Clariom D Assay	PSR0400173021.hg.1	ENST00000263923.4	Ensembl
Affymetrix Human Clariom D Assay	PSR0400173021.hg.1	NM_002253.2	Refseq
Affymetrix Human Clariom D Assay	PSR0400173021.hg.1	ENST00000263923.4	Ensembl
Affymetrix Human Clariom D Assay	PSR0400173021.hg.1	NM_002253.2	Refseq
Affymetrix Human Clariom D Assay	PSR0400173021.hg.1	TC0400010733.hg.1	Clariom D TC