Hs00945899_m1

• Gene Symbol: DNMT1
• Gene Name: DNA (cytosine-5-)-methyltransferase 1
• Gene Aliases: ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI
• Chromosome Location: Chr.19: 10133344 - 10195135 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: DNMT1
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001130823.2	NP_001124295.1	39 - 40	5008		98
	NM_001318730.1	NP_001305659.1	38 - 39	4888		98
	NM_001318731.1	NP_001305660.1	39 - 40	4887		98
	NM_001379.3	NP_001370.1	38 - 39	4960		98
GenBank mRNA	AB209413.2	-	38 - 39	4695		98
	AF180682.1	-	36 - 37	4467		98
	AK122759.1	-	11 - 12	2644		98
	BC092517.1	-	39 - 40	4767	3077831	98
	BC126227.1	-	39 - 40	4952	8991943	98
	BC144093.1	-	39 - 40	4952	9052613	98
	HY245803.1	-	2 - 3			98
	X63692.1	-	38 - 39	4961		98

More Information

Updated Mapping Information

This assay targets the same location as Clariom D transcript cluster(s) TC1900011860.hg.1
This assay targets the same location as HTA transcript cluster(s) TC19001159.hg.1

• Set Membership: Ambion siRNA available, Amplicon length between 86 and 100, Mammalian Gene Collection, Homo sapiens, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene DNMT1

Panther Classification:

Molecular Function -

DNA metabolism protein, DNA methyltransferase, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
DNA methylation
transcription, DNA-templated
Ras protein signal transduction
brain development
aging
response to heat
response to toxic substance
response to ionizing radiation
maintenance of DNA methylation
DNA methylation on cytosine within a CG sequence
positive regulation of gene expression
response to activity
gene silencing
covalent chromatin modification
neuron differentiation
response to caffeine
response to estradiol
response to lipopolysaccharide
response to vitamin A
response to testosterone
cellular response to platelet-derived growth factor stimulus
response to antidepressant
regulation of cell proliferation
DNA hypermethylation
response to ethanol
negative regulation of gene expression, epigenetic
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
S-adenosylmethionine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
cellular response to amino acid stimulus
cellular response to lead ion
cellular response to transforming growth factor beta stimulus
C-5 methylation of cytosine
positive regulation of methylation-dependent chromatin silencing
cellular response to nerve growth factor stimulus

Function(s)

DNA binding
double-stranded DNA binding
RNA binding
DNA (cytosine-5-)-methyltransferase activity
protein binding
zinc ion binding
methyl-CpG binding
DNA-methyltransferase activity
protein domain specific binding
estrogen receptor binding
histone deacetylase binding
unmethylated CpG binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
promoter-specific chromatin binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	PSR19016051.hg.1	ENST00000340748.3	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR19016051.hg.1	ENST00000359526.3	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR19016051.hg.1	ENST00000540357.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR19016051.hg.1	ENST00000541266.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR19016051.hg.1	NM_001130823.2	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR19016051.hg.1	NM_001379.3	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR19016051.hg.1	TC19001159.hg.1	HTA TC
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000340748.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000359526.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000540357.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000586588.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000588913.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000591798.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000592705.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	NM_001130823.2	Refseq
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	NM_001379.3	Refseq
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	TC1900011860.hg.1	Clariom D TC
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000340748.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000359526.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000540357.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000586588.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000588913.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000591798.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	ENST00000592705.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	NM_001130823.2	Refseq
Affymetrix Human Clariom D Assay	PSR1900203952.hg.1	NM_001379.3	Refseq