Hs00999796_m1

• Gene Symbol: LRP6
• Gene Name: LDL receptor related protein 6
• Gene Aliases: ADCAD2, STHAG7
• Chromosome Location: Chr.12: 12116025 - 12267021 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: LRP6
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_002336.2	NP_002327.2	19 - 20	4222		63
	XM_006719078.3	XP_006719141.1	19 - 20	4366		63
	XM_011520671.2	XP_011518973.1	18 - 19	3972		63
	XM_017019304.1	XP_016874793.1	17 - 18	4040		63
GenBank mRNA	AB209683.1	-	18 - 19	3674		63
	AF074264.1	-	19 - 20	4157		63
	AK074543.1	-	4 - 5	590		63
	AK074902.1	-	9 - 10	1759		63
	BC117136.1	-	19 - 20	4114	40125687	63
	BC126405.1	-	19 - 20	4114	8992121	63
	BC143725.1	-	19 - 20	3979	9052239	63

More Information

Updated Mapping Information

This assay targets the same location as Clariom D transcript cluster(s) TC1200009959.hg.1
This assay targets the same location as HTA transcript cluster(s) TC12001251.hg.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Mammalian Gene Collection, Homo sapiens, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene LRP6

Panther Classification:

Molecular Function -

apolipoprotein

Gene Ontology Categories:

Process(es)

neural tube closure
negative regulation of protein phosphorylation
pericardium morphogenesis
negative regulation of protein kinase activity
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
embryonic pattern specification
neural crest formation
neural crest cell differentiation
Wnt signaling pathway
single organismal cell-cell adhesion
cerebellum morphogenesis
thalamus development
cerebral cortex development
midbrain-hindbrain boundary development
negative regulation of smooth muscle cell apoptotic process
external genitalia morphogenesis
odontogenesis of dentin-containing tooth
response to peptide hormone
Wnt signaling pathway involved in dorsal/ventral axis specification
canonical Wnt signaling pathway involved in neural crest cell differentiation
canonical Wnt signaling pathway involved in regulation of cell proliferation
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
palate development
convergent extension
embryonic retina morphogenesis in camera-type eye
canonical Wnt signaling pathway
face morphogenesis
trachea cartilage morphogenesis
cellular response to cholesterol
dopaminergic neuron differentiation
negative regulation of protein serine/threonine kinase activity
protein localization to plasma membrane
primitive streak formation
negative regulation of canonical Wnt signaling pathway
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
Wnt signaling pathway involved in somitogenesis
axis elongation involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
toxin transport
beta-catenin destruction complex disassembly
midbrain dopaminergic neuron differentiation
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

Function(s)

low-density lipoprotein receptor activity
receptor binding
frizzled binding
protein binding
Wnt-protein binding
kinase inhibitor activity
toxin transporter activity
apolipoprotein binding
identical protein binding
protein homodimerization activity
Wnt-activated receptor activity
coreceptor activity involved in Wnt signaling pathway
coreceptor activity involved in canonical Wnt signaling pathway

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	PSR12016348.hg.1	ENST00000261349.4	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12016348.hg.1	ENST00000543091.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12016348.hg.1	NM_002336.2	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR12016348.hg.1	TC12001251.hg.1	HTA TC
Affymetrix Human Clariom D Assay	PSR1200175222.hg.1	ENST00000261349.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1200175222.hg.1	ENST00000538239.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1200175222.hg.1	ENST00000543091.1	Ensembl
Affymetrix Human Clariom D Assay	PSR1200175222.hg.1	NM_002336.2	Refseq
Affymetrix Human Clariom D Assay	PSR1200175222.hg.1	ENST00000261349.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1200175222.hg.1	ENST00000538239.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1200175222.hg.1	ENST00000543091.1	Ensembl
Affymetrix Human Clariom D Assay	PSR1200175222.hg.1	NM_002336.2	Refseq
Affymetrix Human Clariom D Assay	PSR1200175222.hg.1	TC1200009959.hg.1	Clariom D TC