Hs01022434_g1

• Gene Symbol: CASP8
• Gene Name: caspase 8
• Gene Aliases: ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
• Chromosome Location: Chr.2: 201233443 - 201287711 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: CASP8
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001080125.1	NP_001073594.1	4 - 5	933		191
	NM_033355.3	NP_203519.1	5 - 6	764		191
	NM_033358.3	NP_203522.1	5 - 6	858		126
	NR_111983.1		4 - 5	933		191
	XM_005246886.1	XP_005246943.1	4 - 5	679		191
	XM_005246887.1	XP_005246944.1	5 - 6	831		191
	XM_005246888.1	XP_005246945.1	5 - 6	773		191
	XM_005246889.1	XP_005246946.1	4 - 5	650		191
	XM_005246890.3	XP_005246947.1	4 - 5	657		191
	XM_005246891.4	XP_005246948.1	4 - 5	897		191
	XM_005246893.2	XP_005246950.1	4 - 5	753		126
	XM_005246894.3	XP_005246951.1	5 - 6	828		126
	XM_006712789.1	XP_006712852.1	5 - 6	790		191
	XM_006712790.3	XP_006712853.1	4 - 5	669		191
	XM_006712793.2	XP_006712856.1	5 - 6	831		126
	XM_011511969.1	XP_011510271.1	2 - 3	234		191
GenBank mRNA	AF380342.1	-	4 - 5	640		191
	AF422928.1	-	5 - 6	752		191
	BC028223.2	-	3 - 4	582		191
	U58143.1	-	3 - 4	555		191
	X98172.1	-	4 - 5	846		191
	X98176.1	-	5 - 6	744		126
	X98177.1	-	3 - 4	555		191

More Information

Additional Information:

This assay is in the 5'UTR region of the XM_005246894.3 transcripts.

• Set Membership: Ambion siRNA available, Amplicon length greater than or equal to 101, Mammalian Gene Collection, Detect Genomic DNA, Homo sapiens, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene CASP8

Gene Ontology Categories:

Process(es)

proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cellular component disassembly involved in execution phase of apoptosis
cell surface receptor signaling pathway
response to cold
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
natural killer cell activation
macrophage differentiation
response to cobalt ion
response to estradiol
response to lipopolysaccharide
response to tumor necrosis factor
TRIF-dependent toll-like receptor signaling pathway
TRAIL-activated apoptotic signaling pathway
suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
T cell activation
B cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
response to ethanol
positive regulation of macrophage differentiation
positive regulation of proteolysis
response to antibiotic
protein heterooligomerization
proteolysis involved in cellular protein catabolic process
syncytiotrophoblast cell differentiation involved in labyrinthine layer development
nucleotide-binding oligomerization domain containing signaling pathway
cellular response to mechanical stimulus
cellular response to organic cyclic compound
death-inducing signaling complex assembly
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
execution phase of apoptosis
activation of cysteine-type endopeptidase activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Function(s)

cysteine-type endopeptidase activity
death receptor binding
tumor necrosis factor receptor binding
protein binding
peptidase activity
cysteine-type peptidase activity
ubiquitin protein ligase binding
death effector domain binding
identical protein binding
protein-containing complex binding
scaffold protein binding
cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type endopeptidase activity involved in apoptotic signaling pathway

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	PSR02017930.hg.1	ENST00000358485.4	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR02017930.hg.1	ENST00000392258.3	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR02017930.hg.1	ENST00000392259.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR02017930.hg.1	ENST00000432109.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR02017930.hg.1	NM_001080125.1	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR02017930.hg.1	NM_033355.3	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR02017930.hg.1	NM_033358.3	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR02017930.hg.1	TC02001177.hg.1	HTA TC