Hs01066930_m1

• Gene Symbol: MDM2
• Gene Name: MDM2 proto-oncogene
• Gene Aliases: ACTFS, HDMX, hdm2
• Chromosome Location: Chr.12: 68808149 - 68845544 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: MDM2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001145337.2	NP_001138809.1	2 - 3	153		99
	NM_001145339.2	NP_001138811.1	2 - 3	403		99
	NM_001145340.2	NP_001138812.1	2 - 3	153		99
	NM_001278462.1	NP_001265391.1	2 - 3	153		99
	NM_002392.5	NP_002383.2	2 - 3	403		99
	XM_005268872.4	XP_005268929.1	2 - 3	331		99
	XM_006719400.3	XP_006719463.1	2 - 3	426		99
GenBank mRNA	AF092843.1	-	2 - 3	111		99
	AF092844.1	-	2 - 3	111		99
	AF092845.1	-	2 - 3	111		99
	AF385322.1	-	1 - 2	79		99
	AF385323.1	-	1 - 2	79		99
	AF385324.1	-	1 - 2	79		99
	AF385326.1	-	1 - 2	79		99
	AF385327.1	-	1 - 2	79		99
	AJ278975.1	-	1 - 2	79		99
	AJ278977.1	-	1 - 2	79		99
	AJ430612.1	-	1 - 2	79		99
	AJ430614.1	-	1 - 2	79		99
	AJ491698.1	-	1 - 2	79		99
	AJ491699.1	-	1 - 2	79		99
	AJ491700.1	-	1 - 2	79		99
	AJ491701.1	-	1 - 2	79		99
	AJ550517.1	-	1 - 2	79		99
	AJ550518.1	-	1 - 2	79		99
	AJ550519.1	-	1 - 2	79		99
	AK290341.1	-	2 - 3	353		99
	AM902642.1	-	1 - 2	79		99
	AM902643.1	-	1 - 2	79		99
	AM902644.1	-	1 - 2	79		99
	AM902646.1	-	1 - 2	79		99
	AM902647.1	-	1 - 2	79		99
	AM902648.1	-	1 - 2	79		99
	AM902649.1	-	1 - 2	79		99
	AM902650.1	-	1 - 2	79		99
	AM902651.1	-	1 - 2	79		99
	AM902654.1	-	1 - 2	79		99
	AM902655.1	-	1 - 2	79		99
	AM902656.1	-	1 - 2	79		99
	AM902657.1	-	1 - 2	79		99
	AM902658.1	-	1 - 2	79		99
	AM902659.1	-	1 - 2	79		99
	AM902660.1	-	1 - 2	79		99
	AM902661.1	-	1 - 2	79		99
	AM902663.1	-	1 - 2	79		99
	AM902664.1	-	1 - 2	79		99
	AM902665.1	-	1 - 2	79		99
	AM902666.1	-	1 - 2	79		99
	AM902667.1	-	1 - 2	79		99
	AM902668.1	-	1 - 2	79		99
	AM902669.1	-	1 - 2	79		99
	AM902672.1	-	1 - 2	79		99
	AM902674.1	-	1 - 2	79		99
	AM902675.1	-	1 - 2	79		99
	AM902678.1	-	1 - 2	79		99
	AM902679.1	-	1 - 2	79		99
	AM902680.1	-	1 - 2	79		99
	AM902681.1	-	1 - 2	79		99
	BC152384.1	-	1 - 2	82		99
	BC152390.1	-	1 - 2	82		99
	BE296905.1	-	2 - 3	368		99
	BT007258.1	-	1 - 2	79		99
	EU076747.1	-	2 - 3			99
	EU076749.1	-	2 - 3	153		99
	HM213901.1	-	1 - 2	79		99
	HM213902.1	-	1 - 2	79		99
	HM213903.1	-	1 - 2	79		99
	HM213904.1	-	1 - 2	79		99
	HY174841.1	-	2 - 3	405		99
	JX015379.1	-	1 - 2	79		99
	JX015380.1	-	1 - 2	79		99
JX015382.1	-	1 - 2	79		99
JX015383.1	-	1 - 2	79		99
JX015384.1	-	1 - 2	79		99
JX015385.1	-	1 - 2	79		99
JX015387.1	-	1 - 2	79		99
JX015388.1	-	1 - 2	79		99
JX015389.1	-	1 - 2	79		99
JX015390.1	-	1 - 2	79		99
JX015391.1	-	1 - 2	79		99
JX015392.1	-	1 - 2	79		99
M92424.1	-	2 - 3	390		99
U33201.1	-	1 - 2	79		99
U33203.1	-	1 - 2	79		99
Z12020.1	-	2 - 3	390		99

More Information

Updated Mapping Information

This assay targets the same location as Clariom D transcript cluster(s) TC1200008116.hg
This assay targets the same location as HTA transcript cluster(s) TC12000606.hg

Additional Information:

This assay is in the 5'UTR region of the XM_006719400.3 transcripts.

• Set Membership: Ambion siRNA available, Amplicon length between 86 and 100, Apoptosis, Mammalian Gene Collection, Homo sapiens, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene MDM2

Panther Classification:

Molecular Function -

chromatin/chromatin-binding, or -regulatory protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel development
blood vessel remodeling
regulation of heart rate
atrioventricular valve morphogenesis
endocardial cushion morphogenesis
ventricular septum development
atrial septum development
protein complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
traversing start control point of mitotic cell cycle
positive regulation of cell proliferation
response to toxic substance
response to carbohydrate
response to iron ion
positive regulation of gene expression
negative regulation of protein processing
viral process
protein ubiquitination
protein sumoylation
peptidyl-lysine modification
protein destabilization
response to magnesium ion
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein localization to nucleus
regulation of protein catabolic process
response to cocaine
response to drug
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to morphine
negative regulation of DNA damage response, signal transduction by p53 class mediator
establishment of protein localization
response to ether
negative regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
response to antibiotic
positive regulation of protein export from nucleus
response to steroid hormone
cardiac septum morphogenesis
cellular response to hydrogen peroxide
negative regulation of cell cycle arrest
cellular response to antibiotic
cellular response to vitamin B1
cellular response to alkaloid
cellular response to growth factor stimulus
cellular response to peptide hormone stimulus
cellular response to estrogen stimulus
cellular response to hypoxia
cellular response to UV-C
regulation of signal transduction by p53 class mediator
negative regulation of signal transduction by p53 class mediator

Function(s)

p53 binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
SUMO transferase activity
enzyme binding
ubiquitin protein ligase binding
identical protein binding
peroxisome proliferator activated receptor binding
ubiquitin protein ligase activity
scaffold protein binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000258148.7	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000258149.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000299252.4	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000311420.8	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000311440.7	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000356290.4	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000358483.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000393410.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000462284.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000517852.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000544561.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	ENST00000544648.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	NM_002392.5	Refseq
Affymetrix Human Transcriptome Array 2.0	PSR12008008.hg.1	TC12000606.hg.1	HTA TC
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000356290.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000393415.7	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000393416.6	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000523991.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000539479.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000543323.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	NM_001145337.2	Refseq
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	NM_001145340.2	Refseq
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	NM_001278462.1	Refseq
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000356290.8	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000393415.7	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000393416.6	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000523991.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000539479.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	ENST00000543323.5	Ensembl
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	NM_001145337.2	Refseq
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	NM_001145340.2	Refseq
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	NM_001278462.1	Refseq
Affymetrix Human Clariom D Assay	PSR1200159426.hg.1	TC1200008116.hg.1	Clariom D TC