Hs01076074_m1

• Gene Symbol: EGFR
• Gene Name: epidermal growth factor receptor
• Gene Aliases: ERBB, ERBB1, HER1, NISBD2, PIG61, mENA
• Chromosome Location: Chr.7: 55019032 - 55207338 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: EGFR
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_005228.3	NP_005219.2	16 - 17	2168		90
GenBank mRNA	AB209442.1	-	16 - 17	2067		90
	AK225422.1	-	14 - 15	1819		90
	AK290352.1	-	16 - 17	1968		90
	AK294750.1	-	16 - 17	1946		90
	AY550966.1	-	16 - 17	1968		90
	BC094761.1	-	15 - 16	2044	30528231	90
	BC118665.1	-	11 - 12	1304		90
	DQ088980.1	-	16 - 17	1968		90
	GU255993.1	-	16 - 17	1965		90
	HQ912715.1	-	15 - 16	2033		90
	X00588.1	-	16 - 17	2108		90
	X00663.1	-	13 - 14	1496		90

More Information

Updated Mapping Information

This assay targets the same location as Clariom D transcript cluster(s) TC0700007596.hg.1
This assay targets the same location as HTA transcript cluster(s) TC07000328.hg.1

• Set Membership: Ambion siRNA available, Amplicon length between 86 and 100, Apoptosis, Protein Kinase, Mammalian Gene Collection, Homo sapiens, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene EGFR

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPKK activity
cell morphogenesis
ossification
embryonic placenta development
positive regulation of protein phosphorylation
hair follicle development
response to stress
signal transduction
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
activation of phospholipase C activity
salivary gland morphogenesis
learning or memory
cell proliferation
positive regulation of cell proliferation
regulation of phosphatidylinositol 3-kinase signaling
single organismal cell-cell adhesion
peptidyl-tyrosine phosphorylation
cerebral cortex cell migration
positive regulation of cell growth
positive regulation of cell migration
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
positive regulation of catenin import into nucleus
ERBB2 signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of protein catabolic process
positive regulation of phosphorylation
activation of phospholipase A2 activity by calcium-mediated signaling
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of nitric oxide biosynthetic process
positive regulation of DNA repair
positive regulation of DNA replication
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
digestive tract morphogenesis
positive regulation of epithelial cell proliferation
regulation of peptidyl-tyrosine phosphorylation
regulation of nitric-oxide synthase activity
protein insertion into membrane
positive regulation of protein kinase B signaling
morphogenesis of an epithelial fold
eyelid development in camera-type eye
response to UV-A
positive regulation of ERK1 and ERK2 cascade
cellular response to amino acid stimulus
cellular response to epidermal growth factor stimulus
cellular response to estradiol stimulus
positive regulation of production of miRNAs involved in gene silencing by miRNA
regulation of cell motility

Function(s)

chromatin binding
double-stranded DNA binding
MAP kinase kinase kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
transmembrane signaling receptor activity
epidermal growth factor-activated receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
enzyme binding
protein phosphatase binding
nitric-oxide synthase regulator activity
ubiquitin protein ligase binding
identical protein binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
actin filament binding
cadherin binding involved in cell-cell adhesion

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	PSR07004885.hg.1	TC07000328.hg.1	HTA TC
Affymetrix Human Transcriptome Array 2.0	PSR07004885.hg.1	ENST00000275493.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR07004885.hg.1	ENST00000395504.3	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR07004885.hg.1	ENST00000454757.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR07004885.hg.1	ENST00000455089.1	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR07004885.hg.1	ENST00000533450.2	Ensembl
Affymetrix Human Transcriptome Array 2.0	PSR07004885.hg.1	NM_005228.4	Refseq
Affymetrix Human Clariom D Assay	PSR0700152638.hg.1	ENST00000275493.6	Ensembl
Affymetrix Human Clariom D Assay	PSR0700152638.hg.1	ENST00000454757.6	Ensembl
Affymetrix Human Clariom D Assay	PSR0700152638.hg.1	ENST00000455089.5	Ensembl
Affymetrix Human Clariom D Assay	PSR0700152638.hg.1	NM_005228.4	Refseq
Affymetrix Human Clariom D Assay	PSR0700152638.hg.1	ENST00000275493.6	Ensembl
Affymetrix Human Clariom D Assay	PSR0700152638.hg.1	ENST00000454757.6	Ensembl
Affymetrix Human Clariom D Assay	PSR0700152638.hg.1	ENST00000455089.5	Ensembl
Affymetrix Human Clariom D Assay	PSR0700152638.hg.1	NM_005228.4	Refseq
Affymetrix Human Clariom D Assay	PSR0700152638.hg.1	TC0700007596.hg.1	Clariom D TC