Hs04404588_m1

• Gene Symbol: ERBB2
• Gene Name: erb-b2 receptor tyrosine kinase 2
• Gene Aliases: CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
• Chromosome Location: Chr.17: 39688084 - 39728662 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: ERBB2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NR_110535.1		2 - 3	545		93
GenBank mRNA	BC080193.1	-	2 - 3	443		93

Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Transcript Location	Amplicon Length
GenBankmRNA	BQ888953.1	-	2 - 3	442		Chr. 17 - 39700081 - 39709398 [+] on Build GRCh38	93
GenBankmRNA	BM562913.1	-	1 - 2	73		Chr. 17 - 39707128 - 39712037 [+] on Build GRCh38	93
GenBankmRNA	DB283288.1	-	1 - 2	99		Chr. 17 - 39707102 - 39710113 [+] on Build GRCh38	93

Adjacent Gene Details

	Gene name	Gene Symbol	Alias	Distance	Relative Direction	Location Chromsome
Upstream	post-GPI attachment to proteins 3	PGAP3	AGLA546, CAB2, PERLD1, PP1498, hCOS16	-18.9kb	Anti-sense	Chr. 17 - 39671122 - 39688070 on NCBI Build GRCh38
Downstream	microRNA 4728	MIR4728		18.0kb	Sense	Chr. 17 - 39726495 - 39726561 on NCBI Build GRCh38

More Information

• Set Membership: Amplicon length between 86 and 100, Mammalian Gene Collection, Homo sapiens, Probe spans exons

Gene Ontology Categories:

Process(es)

MAPK cascade
positive regulation of protein phosphorylation
transcription, DNA-templated
protein phosphorylation
signal transduction
cell surface receptor signaling pathway
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
peripheral nervous system development
heart development
neuromuscular junction development
motor neuron axon guidance
cell proliferation
phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
positive regulation of cell growth
regulation of microtubule-based process
negative regulation of immature T cell proliferation in thymus
ERBB2 signaling pathway
wound healing
myelination
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of translation
regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase III promoter
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
oligodendrocyte differentiation
positive regulation of epithelial cell proliferation
regulation of ERK1 and ERK2 cascade
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
positive regulation of protein targeting to membrane
regulation of cell motility

Function(s)

RNA polymerase I core binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
transmembrane signaling receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
protein C-terminus binding
growth factor binding
protein phosphatase binding
identical protein binding
ErbB-3 class receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
protein dimerization activity