Hs04989912_s1 Best Coverage

• Gene Symbol: TWIST1
• Gene Name: twist family bHLH transcription factor 1
• Gene Aliases: ACS3, BPES2, BPES3, CRS, CRS1, CSO, SCS, TWIST, bHLHa38
• Chromosome Location: Chr.7: 19113047 - 19117672 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: TWIST1
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_000474.3	NP_000465.1	1	573		65
	XM_011515496.1	XP_011513798.1	1	320		65
GenBank mRNA	BC036704.2	-	1	573	4125830	65
	X99268.1	-	1	332		65

More Information

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Mammalian Gene Collection, Detect Genomic DNA, Recommended Assay, Homo sapiens, Inventoried, Both primers and probe map within a single exon

Matching Ambion siRNAs:

Click here to find siRNAs for Gene TWIST1

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
ossification
osteoblast differentiation
in utero embryonic development
neuron migration
neural tube closure
aortic valve morphogenesis
mitral valve morphogenesis
endocardial cushion morphogenesis
cardiac neural crest cell migration involved in outflow tract morphogenesis
transcription, DNA-templated
muscle organ development
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
negative regulation of phosphatidylinositol 3-kinase signaling
regulation of bone mineralization
positive regulation of fatty acid beta-oxidation
negative regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor production
negative regulation of histone phosphorylation
negative regulation of histone acetylation
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
negative regulation of peroxisome proliferator activated receptor signaling pathway
outer ear morphogenesis
odontogenesis
embryonic digit morphogenesis
negative regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of osteoblast differentiation
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
negative regulation of skeletal muscle tissue development
embryonic cranial skeleton morphogenesis
positive regulation of epithelial cell proliferation
palate development
cranial suture morphogenesis
embryonic camera-type eye formation
eyelid development in camera-type eye
cellular response to growth factor stimulus
cellular response to hypoxia
positive regulation of monocyte chemotactic protein-1 production
positive regulation of DNA-templated transcription, initiation
positive regulation of cell motility
negative regulation of oxidative phosphorylation uncoupler activity
positive regulation of transcription regulatory region DNA binding
negative regulation of cellular senescence
positive regulation of interleukin-6 secretion
negative regulation of double-strand break repair
cell proliferation involved in heart valve development
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
E-box binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	ENST00000242261.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	ENST00000242261.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	ENST00000242261.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	ENST00000242261.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	ENST00000242261.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	ENST00000242261.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	ENST00000354571.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	ENST00000354571.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	ENST00000354571.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	ENST00000354571.5	Ensembl
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	NM_000474.3	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	NM_000474.3	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	NM_000474.3	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	NM_000474.3	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	NM_000474.3	Refseq
Affymetrix Human Transcriptome Array 2.0	TC0700013522.hg.1	NM_000474.3	Refseq