Mm00434227_g1

• Gene Symbol: Il1b
• Gene Name: interleukin 1 beta
• Gene Aliases: IL-1beta, Il-1b
• Chromosome Location: Chr.2: 129363843 - 129371173 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Il1b
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_008361.3	NP_032387.1	2 - 3	114		70
GenBank mRNA	AK168047.1	-	2 - 3	134		70
	AK225002.1	-	2 - 3	133		70
	BC011437.1	-	2 - 3	114	3989461	70
	M15131.1	-	2 - 3	123		70

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0200004602.mm.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Mammalian Gene Collection, Detect Genomic DNA, Mus musculus, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Il1b

Panther Classification:

Molecular Function -

interleukin superfamily

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
activation of MAPK activity
fever generation
positive regulation of protein phosphorylation
inflammatory response
immune response
positive regulation of cytosolic calcium ion concentration
aging
memory
negative regulation of cell proliferation
response to carbohydrate
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
negative regulation of gene expression
negative regulation of glucose transport
positive regulation of cell death
negative regulation of glutamate secretion
cytokine-mediated signaling pathway
hyaluronan biosynthetic process
neutrophil chemotaxis
sequestering of triglyceride
positive regulation of fever generation
lipopolysaccharide-mediated signaling pathway
positive regulation of prostaglandin secretion
response to lipopolysaccharide
interleukin-1 beta production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of stress-activated MAPK cascade
positive regulation of immature T cell proliferation in thymus
response to ATP
positive regulation of heterotypic cell-cell adhesion
social behavior
ectopic germ cell programmed cell death
positive regulation of myosin light chain kinase activity
cellular response to drug
positive regulation of T cell proliferation
positive regulation of NF-kappaB import into nucleus
positive regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAP kinase activity
protein kinase B signaling
positive regulation of JUN kinase activity
positive regulation of chemokine biosynthetic process
positive regulation of interleukin-2 biosynthetic process
positive regulation of interleukin-6 biosynthetic process
positive regulation of nitric oxide biosynthetic process
negative regulation of neuron differentiation
positive regulation of glial cell differentiation
positive regulation of angiogenesis
negative regulation of lipid metabolic process
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
negative regulation of insulin receptor signaling pathway
positive regulation of astrocyte differentiation
positive regulation of phagocytosis
negative regulation of neurogenesis
regulation of insulin secretion
leukocyte migration
negative regulation of lipid catabolic process
positive regulation of lipid catabolic process
positive regulation of membrane protein ectodomain proteolysis
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of cell division
positive regulation of calcidiol 1-monooxygenase activity
negative regulation of adiponectin secretion
positive regulation of ERK1 and ERK2 cascade
monocyte aggregation
cellular response to organic substance
cellular response to organic cyclic compound
positive regulation of monocyte chemotactic protein-1 production
positive regulation of neutrophil chemotaxis
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of branching morphogenesis of a nerve
negative regulation of neural precursor cell proliferation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

receptor binding
cytokine activity
interleukin-1 receptor binding
protein domain specific binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0200039420.mm.1	NM_008361.4	Refseq
Affymetrix Mouse Clariom S Array	PSR0200039420.mm.1	TC0200004602.mm.1	MTA TC