Mm00435944_mH

• Gene Symbol: Map2k1
• Gene Name: mitogen-activated protein kinase kinase 1
• Gene Aliases: MAPKK1, MEKK1, Mek1, Prkmk1
• Chromosome Location: Chr.9: 64185770 - 64253605 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Map2k1
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_008927.3	NP_032953.1	5 - 6	887		66
GenBank mRNA	AB041567.1	-	5 - 6	867		66
	AK146233.1	-	5 - 6	877		66
	AK146931.1	-	5 - 6	880		66
	AK154793.1	-	5 - 6	914		66
	AK165664.1	-	4 - 5	421		66
	AK165894.1	-	5 - 6	888		66
	AK167336.1	-	5 - 6	854		66
	BC051137.1	-	5 - 6	706		66
	BC054754.1	-	5 - 6	666	6411664	66
	L02526.1	-	5 - 6	614		66

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0900002491.mm.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Protein Kinase, Mammalian Gene Collection, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Map2k1

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPK activity
regulation of protein phosphorylation
regulation of vascular smooth muscle contraction
protein phosphorylation
response to oxidative stress
cell cycle arrest
mitotic nuclear division
cell proliferation
negative regulation of cell proliferation
positive regulation of gene expression
phosphorylation
neuron differentiation
keratinocyte differentiation
positive regulation of cell migration
melanosome transport
regulation of stress-activated MAPK cascade
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of homotypic cell-cell adhesion
peptidyl-tyrosine dephosphorylation
positive regulation of GTPase activity
positive regulation of cell differentiation
positive regulation of Ras protein signal transduction
vesicle transport along microtubule
Golgi inheritance
response to axon injury
regulation of axon regeneration
neuron projection morphogenesis
cell motility
positive regulation of axonogenesis
protein heterooligomerization
response to glucocorticoid
lung morphogenesis
trachea formation
epithelial cell proliferation involved in lung morphogenesis
placenta blood vessel development
labyrinthine layer development
ERK1 and ERK2 cascade
positive regulation of protein serine/threonine kinase activity
regulation of Golgi inheritance
cellular senescence
mitophagy in response to mitochondrial depolarization
regulation of early endosome to late endosome transport

Function(s)

nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
receptor signaling protein tyrosine phosphatase activity
protein binding
ATP binding
protein C-terminus binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Ras GTPase binding
protein kinase binding
mitogen-activated protein kinase kinase kinase binding
protein serine/threonine kinase activator activity
protein N-terminus binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0900020895.mm.1	NM_008927.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020895.mm.1	NM_008927.3	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020895.mm.1	TC0900002491.mm.1	MTA TC