Mm00439720_s1

• Gene Symbol: Irs1
• Gene Name: insulin receptor substrate 1
• Gene Aliases: G972R, IRS-1
• Chromosome Location: Chr.1: 82233105 - 82291439 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Irs1
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_010570.4	NP_034700.2	1	2597		113
GenBank mRNA	AK045317.1	-	1	2575		113
	AK142242.1	-	1	2064		113
	L24563.1	-	1	1651		113
	X69722.1	-	1	2123		113

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0100002667.mm.1

• Set Membership: Ambion siRNA available, Amplicon length greater than or equal to 101, Detect Genomic DNA, Mus musculus, Inventoried, Both primers and probe map within a single exon

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Irs1

Gene Ontology Categories:

Process(es)

positive regulation of mesenchymal cell proliferation
signal transduction
insulin receptor signaling pathway
regulation of gene expression
positive regulation of glucose metabolic process
phosphatidylinositol 3-kinase signaling
lipid catabolic process
insulin secretion
positive regulation of cell migration
mammary gland development
response to caffeine
positive regulation of fatty acid beta-oxidation
response to insulin
cellular response to insulin stimulus
protein localization to nucleus
positive regulation of phosphorylation
response to peptide hormone
protein kinase B signaling
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of glycogen biosynthetic process
positive regulation of glucose import
negative regulation of insulin receptor signaling pathway
positive regulation of insulin receptor signaling pathway
negative regulation of insulin secretion
insulin-like growth factor receptor signaling pathway
protein heterooligomerization
positive regulation of glucagon secretion
negative regulation of somatostatin secretion
positive regulation of glucose import in response to insulin stimulus

Function(s)

signal transducer activity
transmembrane receptor protein tyrosine kinase adaptor activity
protein kinase C binding
insulin receptor binding
insulin-like growth factor receptor binding
protein binding
protein kinase binding
protein domain specific binding
SH2 domain binding
phosphatidylinositol 3-kinase binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0100021686.mm.1	NM_010570.4.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0100021686.mm.1	NM_010570.4	Refseq
Affymetrix Mouse Clariom S Array	PSR0100021686.mm.1	TC0100002667.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0100021687.mm.1	NM_010570.4.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0100021687.mm.1	NM_010570.4	Refseq
Affymetrix Mouse Clariom S Array	PSR0100021687.mm.1	TC0100002667.mm.1	MTA TC