Assay Details

Gene Symbol: Ccl2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_011333.3	NP_035463.1	1 - 2	165		74
GenBank mRNA	AF065929.1	-	1 - 2			74
	AF065930.1	-	1 - 2	103		74
	AF065931.1	-	1 - 2	103		74
	AF065932.1	-	1 - 2	103		74
	AF065933.1	-	1 - 2	103		74
	AK132590.1	-	1 - 2	164		74
	AK150937.1	-	1 - 2	166		74
	AK151789.1	-	1 - 2	164		74
	AK153443.1	-	1 - 2	164		74
	AK153468.1	-	1 - 2	166		74
	AK153520.1	-	1 - 2	166		74
	BC055070.1	-	1 - 2	143		74
	BC145867.1	-	1 - 2	132	40131170	74
	BC145869.1	-	1 - 2	132	40131172	74
	CT010187.1	-	1 - 2	80		74

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC1100001219.mm.1

Set Membership:

Ambion siRNA available

Amplicon length between 71 and 85

Mammalian Gene Collection

Recommended Assay

Mus musculus

Mouse Chemokine Panel

Mouse Tumor Metastasis Panel

Mouse Immune Response

Inventoried

Mouse_Immune_Response

Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Ccl2

Panther Classification:

Molecular Function -

cytokine

intercellular signal molecule

Gene Ontology Categories:

Function(s) Process(es)

MicroArray Probes:

Affymetrix

Citations (44)

Parathyroid hormone-related protein promotes inflammation in the kidney with an obstructed ureter.

Authors: Ramila D, Ardura JA, Esteban V, Ortega A, Ruiz-Ortega M, Bosch RJ, Esbrit P
Journal: Kidney Int - Page No 835 (Tue Apr 01 00:00:00 EDT 2008)
Volume (Year): 73 (2008)
Product Usage: -

Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice.

Authors: Hosokawa M, Miyashita T, Nishikawa S, Emi S, Tsukui T, Beppu F, Okada T, Miyashita K
Journal: Arch Biochem Biophys - Page No 17 (Wed Dec 01 00:00:00 EST 2010)
Volume (Year): 504 (2010)
Product Usage: -

Comparative analysis of gene expression changes mediated by individual constituents of hemozoin.

Authors: Schrimpe AC, Wright DW
Journal: Chem Res Toxicol - Page No 433 (Mon Mar 16 00:00:00 EDT 2009)
Volume (Year): 22 (2009)
Product Usage: -

Shilianhua extract inhibits GSK-3beta and promotes glucose metabolism.

Authors: Yin J, Zuberi A, Gao Z, Liu D, Liu Z, Ye J
Journal: Am J Physiol Endocrinol Metab - Page No E1275 (Mon Jun 01 00:00:00 EDT 2009)
Volume (Year): 296 (2009)
Product Usage: -

Comprehensive gene-expression profile in murine oxygen-induced retinopathy.

Authors: Sato T, Kusaka S, Hashida N, Saishin Y, Fujikado T, Tano Y
Journal: Br J Ophthalmol - Page No 96 (Thu Jan 01 00:00:00 EST 2009)
Volume (Year): 93 (2009)
Product Usage: -

Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure.

Authors: Tang T, Zhang J, Yin J, Staszkiewicz J, Gawronska-Kozak B, Jung DY, Ko HJ, Ong H, Kim JK, Mynatt R, Martin RJ, Keenan M, Gao Z, Ye J
Journal: J Biol Chem - Page No 4637 (Fri Feb 12 00:00:00 EST 2010)
Volume (Year): 285 (2010)
Product Usage: -

Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume.

Authors: Zeidler-Erdely PC, Kashon ML, Battelli LA, Young SH, Erdely A, Roberts JR, Reynolds SH, Antonini JM
Journal: Part Fibre Toxicol - Page No 12 (Tue Jan 01 00:00:00 EST 2008)
Volume (Year): 5 (2008)
Product Usage: -

Improved insulin sensitivity in high fat- and high cholesterol-fed Ldlr-/- mice with macrophage-specific transgenic expression of cholesteryl ester hydrolase: role of macrophage inflammation and infiltration into adipose tissue.

Authors: Bie J, Zhao B, Song J, Ghosh S
Journal: J Biol Chem - Page No 13630 (Fri Apr 30 00:00:00 EDT 2010)
Volume (Year): 285 (2010)
Product Usage: -

Interleukin-17 promotes early allograft inflammation.

Authors: Gorbacheva V, Fan R, Li X, Valujskikh A
Journal: Am J Pathol - Page No 1265 (Wed Sep 01 00:00:00 EDT 2010)
Volume (Year): 177 (2010)
Product Usage: -

Fluid Shear Stress Induces Renal Epithelial Gene Expression through Polycystin-2-Dependent Trafficking of Extracellular Regulated Kinase.

Authors: Flores D, Battini L, Gusella GL, Rohatgi R
Journal: Nephron Physiol - Page No p27 (Tue Nov 23 00:00:00 EST 2010)
Volume (Year): 117 (2010)
Product Usage: -

Fibrinogen that appears in Bowman's space of proteinuric kidneys in vivo activates podocyte Toll-like receptors 2 and 4 in vitro.

Authors: Motojima M, Matsusaka T, Kon V, Ichikawa I
Journal: Nephron Exp Nephrol - Page No e39 (Fri Jan 01 00:00:00 EST 2010)
Volume (Year): 114 (2010)
Product Usage: -

Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction.

Authors: Takenaka H, Horiba M, Ishiguro H, Sumida A, Hojo M, Usui A, Akita T, Sakuma S, Ueda Y, Kodama I, Kadomatsu K
Journal: Am J Physiol Heart Circ Physiol - Page No H462 (Sun Feb 01 00:00:00 EST 2009)
Volume (Year): 296 (2009)
Product Usage: -

Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve.

Authors: Uceyler N, Gobel K, Meuth SG, Ortler S, Stoll G, Sommer C, Wiendl H, Kleinschnitz C
Journal: Exp Neurol - Page No 153 (Mon Mar 01 00:00:00 EST 2010)
Volume (Year): 222 (2010)
Product Usage: -

Role of type 1 IFNs in antiglioma immunosurveillance--using mouse studies to guide examination of novel prognostic markers in humans.

Authors: Fujita M, Scheurer ME, Decker SA, McDonald HA, Kohanbash G, Kastenhuber ER, Kato H, Bondy ML, Ohlfest JR, Okada H
Journal: Clin Cancer Res - Page No 3409 (Thu Jul 01 00:00:00 EDT 2010)
Volume (Year): 16 (2010)
Product Usage: -

NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis.

Authors: Vendrov AE, Madamanchi NR, Niu XL, Molnar KC, Runge M, Szyndralewiez C, Page P, Runge MS
Journal: J Biol Chem - Page No 26545 (Fri Aug 20 00:00:00 EDT 2010)
Volume (Year): 285 (2010)
Product Usage: -

Recrudescent Plasmodium berghei from pregnant mice displays enhanced binding to the placenta and induces protection in multigravida.

Authors: Marinho CR, Neres R, Epiphanio S, Goncalves LA, Catarino MB, Penha-Goncalves C
Journal: Plos One - Page No e5630 (Thu Jan 01 00:00:00 EST 2009)
Volume (Year): 4 (2009)
Product Usage: -

Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation.

Authors: Leeper NJ, Tedesco MM, Kojima Y, Schultz GM, Kundu RK, Ashley EA, Tsao PS, Dalman RL, Quertermous T
Journal: Am J Physiol Heart Circ Physiol - Page No H1329 (Fri May 01 00:00:00 EDT 2009)
Volume (Year): 296 (2009)
Product Usage: -

Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11betaHSD1-deficient mice post-MI.

Authors: McSweeney SJ, Hadoke PW, Kozak AM, Small GR, Khaled H, Walker BR, Gray GA
Journal: Cardiovasc Res - Page No 159 (Fri Oct 01 00:00:00 EDT 2010)
Volume (Year): 88 (2010)
Product Usage: -

Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women.

Authors: Neres R, Marinho CR, Goncalves LA, Catarino MB, Penha-Goncalves C
Journal: Plos One - Page No e1608 (Tue Jan 01 00:00:00 EST 2008)
Volume (Year): 3 (2008)
Product Usage: -

Early and rapid engraftment of bone marrow-derived microglia in scrapie.

Authors: Priller J, Prinz M, Heikenwalder M, Zeller N, Schwarz P, Heppner FL, Aguzzi A
Journal: J Neurosci - Page No 11753 (Wed Nov 08 00:00:00 EST 2006)
Volume (Year): 26 (2006)
Product Usage: -

Timed NF-kappaB inhibition in skin reveals dual independent effects on development of HED/EDA and chronic inflammation.

Authors: Ulvmar MH, Sur I, Memet S, Toftgard R
Journal: J Invest Dermatol - Page No 2584 (Sun Nov 01 00:00:00 EDT 2009)
Volume (Year): 129 (2009)
Product Usage: -

Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice.

Authors: Benndorf RA, Krebs C, Hirsch-Hoffmann B, Schwedhelm E, Cieslar G, Schmidt-Haupt R, Steinmetz OM, Meyer-Schwesinger C, Thaiss F, Haddad M, Fehr S, Heilmann A, Helmchen U, Hein L, Ehmke H, Stahl RA, Boger RH, Wenzel UO
Journal: Kidney Int - Page No 1039 (Fri May 01 00:00:00 EDT 2009)
Volume (Year): 75 (2009)
Product Usage: -

Modulation of acute diarrheal illness by persistent bacterial infection.

Authors: McBee ME, Zheng PZ, Rogers AB, Fox JG, Schauer DB
Journal: Infect Immun - Page No 4851 (Sat Nov 01 00:00:00 EDT 2008)
Volume (Year): 76 (2008)
Product Usage: -

Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium.

Authors: Asgeirsdottir SA, Kamps JA, Bakker HI, Zwiers PJ, Heeringa P, van der Weide K, van Goor H, Petersen AH, Morselt H, Moorlag HE, Steenbergen E, Kallenberg CG, Molema G
Journal: Mol Pharmacol - Page No 121 (Sun Jul 01 00:00:00 EDT 2007)
Volume (Year): 72 (2007)
Product Usage: -

Protease-activated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury.

Authors: Antoniak S, Rojas M, Spring D, Bullard TA, Verrier ED, Blaxall BC, Mackman N, Pawlinski R
Journal: Arterioscler Thromb Vasc Biol - Page No 2136 (Mon Nov 01 00:00:00 EDT 2010)
Volume (Year): 30 (2010)
Product Usage: -

Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess.

Authors: Stenzel W, Soltek S, Sanchez-Ruiz M, Akira S, Miletic H, Schluter D, Deckert M
Journal: Am J Pathol - Page No 132 (Tue Jan 01 00:00:00 EST 2008)
Volume (Year): 172 (2008)
Product Usage: -

Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis.

Authors: van der Veen BS, Petersen AH, Belperio JA, Satchell SC, Mathieson PW, Molema G, Heeringa P
Journal: Clin Exp Immunol - Page No 143 (Thu Oct 01 00:00:00 EDT 2009)
Volume (Year): 158 (2009)
Product Usage: -

Lignin-derived lignophenols attenuate oxidative and inflammatory damage to the kidney in streptozotocin-induced diabetic rats.

Authors: Sato S, Mukai Y, Yamate J, Norikura T, Morinaga Y, Mikame K, Funaoka M, Fujita S
Journal: Free Radic Res - Page No 1205 (Tue Dec 01 00:00:00 EST 2009)
Volume (Year): 43 (2009)
Product Usage: -

Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating Toll-like receptor 2 at the glomerular filtration barrier.

Authors: Pawar RD, Castrezana-Lopez L, Allam R, Kulkarni OP, Segerer S, Radomska E, Meyer TN, Schwesinger CM, Akis N, Grone HJ, Anders HJ
Journal: Immunology - Page No e206 (Tue Sep 01 00:00:00 EDT 2009)
Volume (Year): 128 (2009)
Product Usage: -

Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice.

Authors: Sasaki R, Nishimura N, Hoshino H, Isa Y, Kadowaki M, Ichi T, Tanaka A, Nishiumi S, Fukuda I, Ashida H, Horio F, Tsuda T
Journal: Biochem Pharmacol - Page No 1619 (Mon Dec 03 00:00:00 EST 2007)
Volume (Year): 74 (2007)
Product Usage: -

Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice.

Authors: Deng Y, Edin ML, Theken KN, Schuck RN, Flake GP, Kannon MA, Degraff LM, Lih FB, Foley J, Bradbury JA, Graves JP, Tomer KB, Falck JR, Zeldin DC, Lee CR
Journal: Faseb J - Page No (Mon Nov 08 00:00:00 EST 2010)
Volume (Year): (2010)
Product Usage: -

Regulation of the inflammatory response to Staphylococcus aureus-induced brain abscess by interleukin-10.

Authors: Stenzel W, Dahm J, Sanchez-Ruiz M, Miletic H, Hermann M, Courts C, Schwindt H, Utermohlen O, Schluter D, Deckert M
Journal: J Neuropathol Exp Neurol - Page No 1046 (Thu Dec 01 00:00:00 EST 2005)
Volume (Year): 64 (2005)
Product Usage: -

Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens.

Authors: Lech M, Kulkarni OP, Pfeiffer S, Savarese E, Krug A, Garlanda C, Mantovani A, Anders HJ
Journal: J Exp Med - Page No 1879 (Mon Aug 04 00:00:00 EDT 2008)
Volume (Year): 205 (2008)
Product Usage: -

Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation.

Authors: Esteban V, Heringer-Walther S, Sterner-Kock A, de Bruin R, van den Engel S, Wang Y, Mezzano S, Egido J, Schultheiss HP, Ruiz-Ortega M, Walther T
Journal: Plos One - Page No e5406 (Thu Jan 01 00:00:00 EST 2009)
Volume (Year): 4 (2009)
Product Usage: -

Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses.

Authors: Allam R, Pawar RD, Kulkarni OP, Hornung V, Hartmann G, Segerer S, Akira S, Endres S, Anders HJ
Journal: Eur J Immunol - Page No 3487 (Mon Dec 01 00:00:00 EST 2008)
Volume (Year): 38 (2008)
Product Usage: -

Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice.

Authors: Doi K, Okamoto K, Negishi K, Suzuki Y, Nakao A, Fujita T, Toda A, Yokomizo T, Kita Y, Kihara Y, Ishii S, Shimizu T, Noiri E
Journal: Am J Pathol - Page No 1413 (Mon May 01 00:00:00 EDT 2006)
Volume (Year): 168 (2006)
Product Usage: -

CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines.

Authors: Van den Steen PE, Deroost K, Van Aelst I, Geurts N, Martens E, Struyf S, Nie CQ, Hansen DS, Matthys P, Van Damme J, Opdenakker G
Journal: Eur J Immunol - Page No 1082 (Tue Apr 01 00:00:00 EDT 2008)
Volume (Year): 38 (2008)
Product Usage: -

Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model.

Authors: Shindo N, Fujisawa T, Sugimoto K, Nojima K, Oze-Fukai A, Yoshikawa Y, Wang X, Yasuda O, Ikegami H, Rakugi H
Journal: J Hepatol - Page No 903 (Tue Jun 01 00:00:00 EDT 2010)
Volume (Year): 52 (2010)
Product Usage: -

Effects of coffee on inflammatory cytokine gene expression in mice fed high-fat diets.

Authors: Fukushima Y, Kasuga M, Nakao K, Shimomura I, Matsuzawa Y
Journal: J Agric Food Chem - Page No 11100 (Wed Dec 09 00:00:00 EST 2009)
Volume (Year): 57 (2009)
Product Usage: -

Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy.

Authors: Kanamori H, Matsubara T, Mima A, Sumi E, Nagai K, Takahashi T, Abe H, Iehara N, Fukatsu A, Okamoto H, Kita T, Doi T, Arai H
Journal: Biochem Biophys Res Commun - Page No 772 (Fri Sep 07 00:00:00 EDT 2007)
Volume (Year): 360 (2007)
Product Usage: -

N-type calcium channel in the pathogenesis of experimental autoimmune encephalomyelitis.

Authors: Tokuhara N, Namiki K, Uesugi M, Miyamoto C, Ohgoh M, Ido K, Yoshinaga T, Yamauchi T, Kuromitsu J, Kimura S, Miyamoto N, Kasuya Y
Journal: J Biol Chem - Page No 33294 (Fri Oct 22 00:00:00 EDT 2010)
Volume (Year): 285 (2010)
Product Usage: -

Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.

Authors: Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, Oshima M, Fujii C, Mukaida N
Journal: J Clin Invest - Page No 560 (Fri Feb 01 00:00:00 EST 2008)
Volume (Year): 118 (2008)
Product Usage: -

SIGIRR modulates the inflammatory response in the brain.

Authors: Watson MB, Costello DA, Carney DG, McQuillan K, Lynch MA
Journal: Brain Behav Immun - Page No 985 (Sun Aug 01 00:00:00 EDT 2010)
Volume (Year): 24 (2010)
Product Usage: -

Treatment with chondroitinase ABC alleviates bleomycin-induced pulmonary fibrosis.

Authors: Kai Y, Yoneyama H, Koyama J, Hamada K, Kimura H, Matsushima K
Journal: Med Mol Morphol - Page No 128 (Sat Sep 01 00:00:00 EDT 2007)
Volume (Year): 40 (2007)
Product Usage: -

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Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR1100011445.mm.1	NM_011333.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1100011445.mm.1	NM_011333.3	Refseq
Affymetrix Mouse Clariom S Array	PSR1100011445.mm.1	TC1100001219.mm.1	MTA TC

System Message

Genomic Map