Mm00448405_m1 Best Coverage

• Gene Symbol: Psen2
• Gene Name: presenilin 2
• Gene Aliases: ALG-3, Ad4h, Alg3, PS-2, PS2, Psnl2, STM2
• Chromosome Location: Chr.1: 180227004 - 180263476 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Psen2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001128605.1	NP_001122077.1	2 - 3	225		70
	NM_011183.3	NP_035313.2	2 - 3	234		70
GenBank mRNA	AK148111.1	-	2 - 3	226		70
	AK154119.1	-	2 - 3	170		70
	BC010403.1	-	1 - 2	180	4038761	70
	BY136632.1	-	2 - 3	234		70
	U57324.1	-	2 - 3	185		70

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0100003664.mm.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Protease, Mammalian Gene Collection, Recommended Assay, Mus musculus, Mouse Alzheimer's Disease, 1700, Inventoried, Mouse_Alzheimer, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Psen2

Panther Classification:

Molecular Function -

aspartic protease

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
cell fate specification
somitogenesis
positive regulation of receptor recycling
negative regulation of protein phosphorylation
hair follicle development
hematopoietic progenitor cell differentiation
T cell activation involved in immune response
myeloid leukocyte differentiation
proteolysis
membrane protein ectodomain proteolysis
calcium ion transport
negative regulation of epidermal growth factor-activated receptor activity
regulation of epidermal growth factor-activated receptor activity
Notch signaling pathway
Notch receptor processing
learning or memory
memory
embryo development
protein transport
protein processing
dorsal/ventral neural tube patterning
embryonic limb morphogenesis
forebrain development
negative regulation of protein complex assembly
negative regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
endoplasmic reticulum calcium ion homeostasis
intracellular signal transduction
locomotion
anagen
amyloid precursor protein catabolic process
positive regulation of apoptotic process
positive regulation of catalytic activity
regulation of protein binding
skin morphogenesis
cellular protein metabolic process
regulation of synaptic plasticity
lung alveolus development
thymus development
brain morphogenesis
beta-amyloid metabolic process
positive regulation of coagulation
T cell receptor signaling pathway
negative regulation of ubiquitin-protein transferase activity
protein maturation
cardiac muscle contraction
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic signaling pathway

Function(s)

endopeptidase activity
aspartic-type endopeptidase activity
protein binding
peptidase activity
hydrolase activity
aspartic endopeptidase activity, intramembrane cleaving

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0100030139.mm.1	NM_001128605.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0100030139.mm.1	NM_001128605.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0100030139.mm.1	NM_011183.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0100030139.mm.1	NM_011183.3	Refseq
Affymetrix Mouse Clariom S Array	PSR0100030139.mm.1	TC0100003664.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0100030141.mm.1	NM_001128605.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0100030141.mm.1	NM_001128605.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0100030141.mm.1	NM_011183.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0100030141.mm.1	NM_011183.3	Refseq
Affymetrix Mouse Clariom S Array	PSR0100030141.mm.1	TC0100003664.mm.1	MTA TC

Array Name	Probe IDs	Targets	Target Type
ABI Mouse Genome Survey Microarray	494716	-	-