Mm00448426_m1

• Gene Symbol: Ptpn1
• Gene Name: protein tyrosine phosphatase, non-receptor type 1
• Gene Aliases: PTP-1B, PTP-HA2, PTP1B
• Chromosome Location: Chr.2: 167932303 - 167979385 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Ptpn1
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_011201.3	NP_035331.3	3 - 4	426		61
GenBank mRNA	AK149979.1	-	3 - 4	382		61
	AK150322.1	-	3 - 4	382		61
	AK151371.1	-	3 - 4	339		61
	AK153088.1	-	3 - 4	365		61
	AK156281.1	-	3 - 4	387		61
	AK157431.1	-	3 - 4	427		61
	AK165567.1	-	3 - 4	391		61
	AK165949.1	-	4 - 5	506		61
	AK166020.1	-	3 - 4	382		61
	AK168772.1	-	3 - 4	381		61
	AK170620.1	-	3 - 4	382		61
	AK171380.1	-	3 - 4	382		61
	AK172206.1	-	4 - 5	499		61
	AK185938.1	-	2 - 3	133		61
	BC010191.1	-	3 - 4	344	3156854	61
	M97590.1	-	3 - 4	342		61

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0200002602.mm.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Protein Phosphatase, Mammalian Gene Collection, Mus musculus, 1700, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Ptpn1

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

protein dephosphorylation
activation of JUN kinase activity
insulin receptor signaling pathway
regulation of signal transduction
dephosphorylation
regulation of endocytosis
negative regulation of vascular endothelial growth factor receptor signaling pathway
endoplasmic reticulum unfolded protein response
actin cytoskeleton reorganization
regulation of intracellular protein transport
response to endoplasmic reticulum stress
peptidyl-tyrosine dephosphorylation
platelet-derived growth factor receptor-beta signaling pathway
IRE1-mediated unfolded protein response
negative regulation of MAP kinase activity
regulation of insulin receptor signaling pathway
positive regulation of protein tyrosine kinase activity
negative regulation of ERK1 and ERK2 cascade
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of PERK-mediated unfolded protein response
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
positive regulation of receptor catabolic process

Function(s)

phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
insulin receptor binding
zinc ion binding
hydrolase activity
phosphatase activity
enzyme binding
protein kinase binding
receptor tyrosine kinase binding
poly(A) RNA binding
ephrin receptor binding
protein phosphatase 2A binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0200021432.mm.1	NM_011201.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0200021432.mm.1	NM_011201.3	Refseq
Affymetrix Mouse Clariom S Array	PSR0200021432.mm.1	TC0200002602.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0200021435.mm.1	NM_011201.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0200021435.mm.1	NM_011201.3	Refseq
Affymetrix Mouse Clariom S Array	PSR0200021435.mm.1	TC0200002602.mm.1	MTA TC

Array Name	Probe IDs	Targets	Target Type
ABI Mouse Genome Survey Microarray	311052	-	-