Mm00448445_m1

• Gene Symbol: Ptpn11
• Gene Name: protein tyrosine phosphatase, non-receptor type 11
• Gene Aliases: 2700084A17Rik, AW536184, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, Syp
• Chromosome Location: Chr.5: 121130533 - 121191397 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Ptpn11
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001109992.1	NP_001103462.1	14 - 15	1900		102
	NM_011202.3	NP_035332.1	14 - 15	1912		102
GenBank mRNA	AK147354.1	-	13 - 14	3746		102
	AK159501.1	-	14 - 15	1900		102
	AK159587.1	-	14 - 15	1900		102
	AK163809.1	-	11 - 12	1328		102
	BC057398.1	-	14 - 15	1844	6409640	102
	BC059278.1	-	14 - 15	1878	2866038	102
	D84372.1	-	14 - 15	1788		102

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0500003184.mm.1

• Set Membership: Ambion siRNA available, Amplicon length greater than or equal to 101, Protein Phosphatase, Mammalian Gene Collection, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Ptpn11

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

DNA damage checkpoint
activation of MAPK activity
protein dephosphorylation
lipid metabolic process
triglyceride metabolic process
epidermal growth factor receptor signaling pathway
integrin-mediated signaling pathway
axonogenesis
brain development
heart development
hormone-mediated signaling pathway
positive regulation of signal transduction
dephosphorylation
platelet formation
microvillus organization
abortive mitotic cell cycle
regulation of cell adhesion mediated by integrin
negative regulation of cell adhesion mediated by integrin
multicellular organism growth
organ growth
peptidyl-tyrosine dephosphorylation
megakaryocyte development
atrioventricular canal development
ERBB signaling pathway
regulation of multicellular organism growth
hormone metabolic process
glucose homeostasis
positive regulation of mitotic cell cycle
negative regulation of insulin secretion
regulation of protein export from nucleus
positive regulation of hormone secretion
negative regulation of hormone secretion
platelet-derived growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
ephrin receptor signaling pathway
multicellular organismal reproductive process
genitalia development
inner ear development
homeostasis of number of cells within a tissue
negative regulation of cortisol secretion
negative regulation of growth hormone secretion
face morphogenesis
intestinal epithelial cell migration
positive regulation of ERK1 and ERK2 cascade
positive regulation of glucose import in response to insulin stimulus

Function(s)

phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
SH3/SH2 adaptor activity
insulin receptor binding
protein binding
hydrolase activity
phosphatase activity
protein domain specific binding
receptor tyrosine kinase binding
D1 dopamine receptor binding
phospholipase binding
insulin receptor substrate binding
peptide hormone receptor binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0500028314.mm.1	TC0500003184.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0500028314.mm.1	NM_001109992.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028314.mm.1	NM_001109992.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028314.mm.1	NM_011202.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028314.mm.1	NM_011202.3	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028316.mm.1	TC0500003184.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0500028316.mm.1	NM_001109992.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028316.mm.1	NM_001109992.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028316.mm.1	NM_011202.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028316.mm.1	NM_011202.3	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028315.mm.1	TC0500003184.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0500028315.mm.1	NM_001109992.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028315.mm.1	NM_001109992.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028315.mm.1	NM_011202.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028315.mm.1	NM_011202.3	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028317.mm.1	TC0500003184.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0500028317.mm.1	NM_001109992.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028317.mm.1	NM_001109992.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028317.mm.1	NM_011202.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0500028317.mm.1	NM_011202.3	Refseq