Mm00463738_m1

• Gene Symbol: Pcsk9
• Gene Name: proprotein convertase subtilisin/kexin type 9
• Gene Aliases: AI415265, AI747682, FH3, HCHOLA3, Narc1, PC9
• Chromosome Location: Chr.4: 106442334 - 106464325 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Pcsk9
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_153565.2	NP_705793.1	3 - 4	949		79
GenBank mRNA	AK043077.1	-	3 - 4	799		79
	AK149520.1	-	3 - 4	728		79
	AY273821.1	-	3 - 4	573		79
	BC038085.1	-	3 - 4	964	4502199	79

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0400003200.mm.1

• Set Membership: Ambion siRNA available, Amplicon length between 71 and 85, Protease, Mammalian Gene Collection, Mus musculus, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Pcsk9

Panther Classification:

Molecular Function -

serine protease

Gene Ontology Categories:

Process(es)

negative regulation of receptor recycling
positive regulation of receptor internalization
proteolysis
lipid metabolic process
triglyceride metabolic process
phospholipid metabolic process
apoptotic process
lysosomal transport
steroid metabolic process
cholesterol metabolic process
cellular response to starvation
regulation of receptor activity
negative regulation of low-density lipoprotein particle clearance
protein processing
protein autoprocessing
neuron differentiation
low-density lipoprotein receptor particle metabolic process
low-density lipoprotein particle receptor catabolic process
regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
lipoprotein metabolic process
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of receptor activity
negative regulation of sodium ion transmembrane transporter activity

Function(s)

serine-type endopeptidase activity
peptidase activity
serine-type peptidase activity
hydrolase activity
sodium channel inhibitor activity
low-density lipoprotein particle binding
receptor inhibitor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
protein self-association
poly(A) RNA binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0400025363.mm.1	TC0400003200.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0400025363.mm.1	NM_153565.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0400025363.mm.1	NM_153565.2	Refseq