Mm00468875_m1

• Gene Symbol: Hif1a
• Gene Name: hypoxia inducible factor 1, alpha subunit
• Gene Aliases: AA959795, HIF1alpha, MOP1, bHLHe78
• Chromosome Location: Chr.12: 73901329 - 73947530 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Hif1a
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_010431.2	NP_034561.2	10 - 11	1957		88
GenBank mRNA	AF003695.1	-	10 - 11	1791		88
	AK034087.1	-	10 - 11	1923		88
	AK076395.1	-	8 - 9	1245		88
	AK150367.1	-	10 - 11	1824		88
	BC026139.1	-	10 - 11	1809	4019056	88

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC1200000652.mm.1

• Set Membership: Ambion siRNA available, Amplicon length between 86 and 100, Mammalian Gene Collection, Mus musculus, Mouse Chemokine Panel, Mouse Hypoxia Panel, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Hif1a

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

angiogenesis
blood vessel development
response to hypoxia
neural crest cell migration
epithelial to mesenchymal transition
embryonic placenta development
B-1 B cell homeostasis
vasculature development
heart looping
positive regulation of neuroblast proliferation
connective tissue replacement involved in inflammatory response wound healing
outflow tract morphogenesis
cardiac ventricle morphogenesis
lactate metabolic process
regulation of glycolytic process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular iron ion homeostasis
signal transduction
lactation
positive regulation of cell proliferation
visual learning
regulation of gene expression
positive regulation of autophagy
vascular endothelial growth factor production
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of receptor biosynthetic process
response to muscle activity
axonal transport of mitochondrion
neural fold elevation formation
cerebral cortex development
cell differentiation
negative regulation of bone mineralization
positive regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of TOR signaling
oxygen homeostasis
regulation of transforming growth factor beta2 production
collagen metabolic process
negative regulation of transcription elongation from RNA polymerase II promoter
embryonic hemopoiesis
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of cell proliferation
hemoglobin biosynthetic process
glucose homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
positive regulation of erythrocyte differentiation
positive regulation of transcription, DNA-templated
negative regulation of vasoconstriction
negative regulation of growth
positive regulation of transcription from RNA polymerase II promoter
muscle cell cellular homeostasis
positive regulation of hormone biosynthetic process
blood vessel morphogenesis
digestive tract morphogenesis
positive regulation of smooth muscle cell proliferation
regulation of catalytic activity
cartilage development
elastin metabolic process
intestinal epithelial cell maturation
response to fungicide
epithelial cell differentiation involved in mammary gland alveolus development
retina vasculature development in camera-type eye
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of thymocyte apoptotic process
negative regulation of thymocyte apoptotic process
cellular response to hypoxia
dopaminergic neuron differentiation
hypoxia-inducible factor-1alpha signaling pathway
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of mitophagy
regulation of aerobic respiration
negative regulation of reactive oxygen species metabolic process
negative regulation of mesenchymal cell apoptotic process

Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, transcription factor binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
signal transducer activity
protein binding
transcription factor binding
enzyme binding
protein kinase binding
ubiquitin protein ligase binding
protein complex binding
histone acetyltransferase binding
nuclear hormone receptor binding
histone deacetylase binding
sequence-specific DNA binding
protein heterodimerization activity
protein dimerization activity
Hsp90 protein binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR1200004502.mm.1	NM_010431.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1200004502.mm.1	NM_010431.2	Refseq
Affymetrix Mouse Clariom S Array	PSR1200004502.mm.1	TC1200000652.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR1200004503.mm.1	NM_010431.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1200004503.mm.1	NM_010431.2	Refseq
Affymetrix Mouse Clariom S Array	PSR1200004503.mm.1	TC1200000652.mm.1	MTA TC