Assay Details

Gene Symbol: Ptgs2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_011198.3	NP_035328.2	5 - 6	738		80
GenBank mRNA	AK049923.1	-	5 - 6	729		80
	AK144726.1	-	5 - 6	763		80
	AK144956.1	-	5 - 6	761		80
	AK166221.1	-	5 - 6	761		80
	AK172161.1	-	5 - 6	763		80
	BC052900.1	-	5 - 6	734	30059181	80
	M64291.1	-	5 - 6	762		80
	M88242.1	-	5 - 6	738		80
	M94967.1	-	5 - 6	763		80

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0100001338.mm.1

Set Membership:

Ambion siRNA available

Amplicon length between 71 and 85

Mammalian Gene Collection

Recommended Assay

Mus musculus

Mouse Tumor Metastasis Panel

Mouse lipid regulated genes

Mouse Immune Response

Inventoried

Mouse_lipid_regulated_genes

Mouse_Immune_Response

Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Ptgs2

Panther Classification:

Molecular Function -

oxygenase

Gene Ontology Categories:

Function(s) Process(es)

MicroArray Probes:

Affymetrix

Citations (28)

The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.

Authors: Facemire CS, Griffiths R, Audoly LP, Koller BH, Coffman TM
Journal: Hypertension - Page No 531 (Mon Feb 01 00:00:00 EST 2010)
Volume (Year): 55 (2010)
Product Usage: -

Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice.

Authors: Hosokawa M, Miyashita T, Nishikawa S, Emi S, Tsukui T, Beppu F, Okada T, Miyashita K
Journal: Arch Biochem Biophys - Page No 17 (Wed Dec 01 00:00:00 EST 2010)
Volume (Year): 504 (2010)
Product Usage: -

Generation of antigen-presenting cells from tumor-infiltrated CD11b myeloid cells with DNA demethylating agent 5-aza-2'-deoxycytidine.

Authors: Daurkin I, Eruslanov E, Vieweg J, Kusmartsev S
Journal: Cancer Immunol Immunother - Page No 697 (Sat May 01 00:00:00 EDT 2010)
Volume (Year): 59 (2010)
Product Usage: -

Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells.

Authors: Bezencon C, Furholz A, Raymond F, Mansourian R, Metairon S, Le Coutre J, Damak S
Journal: J Comp Neurol - Page No 514 (Sun Aug 10 00:00:00 EDT 2008)
Volume (Year): 509 (2008)
Product Usage: -

High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo.

Authors: Faraco G, Fossati S, Bianchi ME, Patrone M, Pedrazzi M, Sparatore B, Moroni F, Chiarugi A
Journal: J Neurochem - Page No 590 (Mon Oct 01 00:00:00 EDT 2007)
Volume (Year): 103 (2007)
Product Usage: -

Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland.

Authors: Chandrasekharan S, Foley NA, Jania L, Clark P, Audoly LP, Koller BH
Journal: J Lipid Res - Page No 2636 (Thu Dec 01 00:00:00 EST 2005)
Volume (Year): 46 (2005)
Product Usage: -

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

Authors: Arlt VM, Stiborova M, Henderson CJ, Thiemann M, Frei E, Aimova D, Singh R, Gamboa da Costa G, Schmitz OJ, Farmer PB, Wolf CR, Phillips DH
Journal: Carcinogenesis - Page No 656 (Sat Mar 01 00:00:00 EST 2008)
Volume (Year): 29 (2008)
Product Usage: -

Mutant alpha-synuclein overexpression mediates early proinflammatory activity.

Authors: Su X, Federoff HJ, Maguire-Zeiss KA
Journal: Neurotox Res - Page No 238 (Thu Oct 01 00:00:00 EDT 2009)
Volume (Year): 16 (2009)
Product Usage: -

Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells.

Authors: Kwon RY, Temiyasathit S, Tummala P, Quah CC, Jacobs CR
Journal: Faseb J - Page No 2859 (Sun Aug 01 00:00:00 EDT 2010)
Volume (Year): 24 (2010)
Product Usage: -

Suppressive effects of alloxanthin and diatoxanthin from Halocynthia roretzi on LPS-induced expression of pro-inflammatory genes in RAW264.7 cells.

Authors: Konishi I, Hosokawa M, Sashima T, Maoka T, Miyashita K
Journal: J Oleo Sci - Page No 181 (Tue Jan 01 00:00:00 EST 2008)
Volume (Year): 57 (2008)
Product Usage: -

Endogenous interleukin-10 inhibits angiotensin II-induced vascular dysfunction.

Authors: Didion SP, Kinzenbaw DA, Schrader LI, Chu Y, Faraci FM
Journal: Hypertension - Page No 619 (Tue Sep 01 00:00:00 EDT 2009)
Volume (Year): 54 (2009)
Product Usage: -

Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA.

Authors: Gonzalez-Periz A, Planaguma A, Gronert K, Miquel R, Lopez-Parra M, Titos E, Horrillo R, Ferre N, Deulofeu R, Arroyo V, Rodes J, Claria J
Journal: Faseb J - Page No 2537 (Fri Dec 01 00:00:00 EST 2006)
Volume (Year): 20 (2006)
Product Usage: -

Role of microsomal prostaglandin E synthase 1 in the kidney.

Authors: Francois H, Facemire C, Kumar A, Audoly L, Koller B, Coffman T
Journal: J Am Soc Nephrol - Page No 1466 (Tue May 01 00:00:00 EDT 2007)
Volume (Year): 18 (2007)
Product Usage: -

Suppressive effects of extracts from the aerial part of Coriandrum sativum L. on LPS-induced inflammatory responses in murine RAW 264.7 macrophages.

Authors: Wu TT, Tsai CW, Yao HT, Lii CK, Chen HW, Wu YL, Chen PY, Liu KL
Journal: J Sci Food Agric - Page No 1846 (Mon Aug 30 00:00:00 EDT 2010)
Volume (Year): 90 (2010)
Product Usage: -

Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor.

Authors: Chen J, Zhao M, He W, Milne GL, Howard JR, Morrow J, Hebert RL, Breyer RM, Chen J, Hao CM
Journal: Am J Physiol Renal Physiol - Page No F818 (Mon Sep 01 00:00:00 EDT 2008)
Volume (Year): 295 (2008)
Product Usage: -

Psychological stress reactivates dextran sulfate sodium-induced chronic colitis in mice.

Authors: Melgar S, Engstrom K, Jagervall A, Martinez V
Journal: Stress - Page No 348 (Tue Jan 01 00:00:00 EST 2008)
Volume (Year): 11 (2008)
Product Usage: -

Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice.

Authors: Callewaert F, Bakker A, Schrooten J, Van Meerbeek B, Verhoeven G, Boonen S, Vanderschueren D
Journal: J Bone Miner Res - Page No 124 (Fri Jan 01 00:00:00 EST 2010)
Volume (Year): 25 (2010)
Product Usage: -

Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition.

Authors: Tong X, Van Dross RT, Abu-Yousif A, Morrison AR, Pelling JC
Journal: Mol Cell Biol - Page No 283 (Mon Jan 01 00:00:00 EST 2007)
Volume (Year): 27 (2007)
Product Usage: -

Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models.

Authors: Morihara T, Teter B, Yang F, Lim GP, Boudinot S, Boudinot FD, Frautschy SA, Cole GM
Journal: Neuropsychopharmacology - Page No 1111 (Wed Jun 01 00:00:00 EDT 2005)
Volume (Year): 30 (2005)
Product Usage: -

Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models.

Authors: Svec J, Ergang P, Mandys V, Kment M, Pacha J
Journal: Int J Exp Pathol - Page No 44 (Mon Feb 01 00:00:00 EST 2010)
Volume (Year): 91 (2010)
Product Usage: -

Comprehensive mRNA profiling of lipid-related genes in microglia and macrophages using taqman arrays.

Authors: Mauerer R, Walczak Y, Langmann T
Journal: Methods Mol Biol - Page No 187 (Thu Jan 01 00:00:00 EST 2009)
Volume (Year): 580 (2009)
Product Usage: -

Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation.

Authors: Wang M, Lee E, Song W, Ricciotti E, Rader DJ, Lawson JA, Pure E, FitzGerald GA
Journal: Circulation - Page No 1302 (Tue Mar 11 00:00:00 EDT 2008)
Volume (Year): 117 (2008)
Product Usage: -

The Ski proto-oncogene regulates body composition and suppresses lipogenesis.

Authors: Leong GM, Kee AJ, Millard SM, Martel N, Eriksson N, Turner N, Cooney GJ, Hardeman EC, Muscat GE
Journal: Int J Obes (Lond) - Page No 524 (Mon Mar 01 00:00:00 EST 2010)
Volume (Year): 34 (2010)
Product Usage: -

Stable expression and characterization of N-terminal tagged recombinant human bone morphogenetic protein 15.

Authors: Li Q, Rajanahally S, Edson MA, Matzuk MM
Journal: Mol Hum Reprod - Page No 779 (Tue Dec 01 00:00:00 EST 2009)
Volume (Year): 15 (2009)
Product Usage: -

Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo.

Authors: Li Q, Pangas SA, Jorgez CJ, Graff JM, Weinstein M, Matzuk MM
Journal: Mol Cell Biol - Page No 7001 (Mon Dec 01 00:00:00 EST 2008)
Volume (Year): 28 (2008)
Product Usage: -

Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse.

Authors: Mukherjee A, Soyal SM, Fernandez-Valdivia R, Gehin M, Chambon P, Demayo FJ, Lydon JP, O'Malley BW
Journal: Mol Cell Biol - Page No 6571 (Fri Sep 01 00:00:00 EDT 2006)
Volume (Year): 26 (2006)
Product Usage: -

Comparison of microsomal prostaglandin E synthase-1 deletion and COX-2 inhibition in acute cardiac ischemia in mice.

Authors: Wu D, Mennerich D, Arndt K, Sugiyama K, Ozaki N, Schwarz K, Wei J, Wu H, Bishopric NH, Doods H
Journal: Prostaglandins Other Lipid Mediat - Page No 21 (Sun Nov 01 00:00:00 EDT 2009)
Volume (Year): 90 (2009)
Product Usage: -

Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.

Authors: Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, Oshima M, Fujii C, Mukaida N
Journal: J Clin Invest - Page No 560 (Fri Feb 01 00:00:00 EST 2008)
Volume (Year): 118 (2008)
Product Usage: -

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Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0100011025.mm.1	NM_011198.4	Refseq
Affymetrix Mouse Clariom S Array	PSR0100011025.mm.1	TC0100001338.mm.1	MTA TC

System Message

Genomic Map