Mm00488649_m1

• Gene Symbol: Map2k5
• Gene Name: mitogen-activated protein kinase kinase 5
• Gene Aliases: AI324775, AI428457, MEK5, Mapkk5, Prkmk5
• Chromosome Location: Chr.9: 63163768 - 63378438 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Map2k5
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_011840.2	NP_035970.1	1 - 2	728		62
GenBank mRNA	AB019374.1	-	1 - 2	729		62
	AK020716.1	-	1 - 2	756		62
	AK159261.1	-	1 - 2	779		62
	AK166137.1	-	1 - 2	779		62
	BC013697.1	-	1 - 2	719		62
	BC028260.1	-	1 - 2	608	5067818	62

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0900002472.mm.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Mammalian Gene Collection, Mus musculus, 1700, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Map2k5

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
activation of MAPK activity
protein phosphorylation
heart development
phosphorylation
positive regulation of cell growth
negative regulation of NF-kappaB transcription factor activity
negative regulation of heterotypic cell-cell adhesion
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of interleukin-8 biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of epithelial cell proliferation
positive regulation of protein metabolic process
negative regulation of response to cytokine stimulus
ERK5 cascade
cellular response to growth factor stimulus
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of chemokine (C-X-C motif) ligand 2 production
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0900020718.mm.1	NM_011840.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020718.mm.1	NM_011840.2	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020718.mm.1	TC0900002472.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0900020717.mm.1	NM_011840.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020717.mm.1	NM_011840.2	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020717.mm.1	TC0900002472.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0900020716.mm.1	NM_011840.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020716.mm.1	NM_011840.2	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020716.mm.1	TC0900002472.mm.1	MTA TC

Array Name	Probe IDs	Targets	Target Type
ABI Mouse Genome Survey Microarray	743725	-	-