Mm00500566_m1

• Gene Symbol: Msh2
• Gene Name: mutS homolog 2 (E. coli)
• Gene Aliases: AI788990
• Chromosome Location: Chr.17: 87672557 - 87723713 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Msh2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_008628.2	NP_032654.1	7 - 8	1321		75
GenBank mRNA	AK051960.1	-	7 - 8	1318		75
	AK157842.1	-	7 - 8	1334		75
	BC047117.1	-	7 - 8	1329	4951173	75
	BC050897.1	-	7 - 8	1304	6401835	75
	U21011.1	-	7 - 8	1338		75
	X81143.1	-	7 - 8	1321		75

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC1700001313.mm.1

• Set Membership: Ambion siRNA available, Amplicon length between 71 and 85, Mammalian Gene Collection, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Msh2

Gene Ontology Categories:

Process(es)

meiotic mismatch repair
in utero embryonic development
somatic recombination of immunoglobulin genes involved in immune response
oxidative phosphorylation
DNA repair
mismatch repair
postreplication repair
double-strand break repair
meiotic gene conversion
cellular response to DNA damage stimulus
cell cycle
reciprocal meiotic recombination
germ cell development
determination of adult lifespan
male gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to UV-B
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
B cell mediated immunity
B cell differentiation
mitotic intra-S DNA damage checkpoint signaling
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of neuron apoptotic process
maintenance of DNA repeat elements
negative regulation of reciprocal meiotic recombination
isotype switching
negative regulation of DNA recombination
positive regulation of helicase activity

Function(s)

nucleotide binding
magnesium ion binding
four-way junction DNA binding
Y-form DNA binding
heteroduplex DNA loop binding
double-strand/single-strand DNA junction binding
DNA binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
ATP binding
protein C-terminus binding
ATP-dependent activity, acting on DNA
ATP hydrolysis activity
centromeric DNA binding
enzyme binding
protein kinase binding
mismatched DNA binding
guanine/thymine mispair binding
single base insertion or deletion binding
dinucleotide insertion or deletion binding
single guanine insertion binding
single thymine insertion binding
dinucleotide repeat insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR1700011983.mm.1	TC1700001313.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR1700011983.mm.1	NM_008628.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1700011983.mm.1	NM_008628.2	Refseq
Affymetrix Mouse Clariom S Array	PSR1700011984.mm.1	TC1700001313.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR1700011984.mm.1	NM_008628.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1700011984.mm.1	NM_008628.2	Refseq