Mm00627105_m1

• Gene Symbol: Smad4
• Gene Name: SMAD family member 4
• Gene Aliases: AW743858, D18Wsu70e, DPC4, Madh4
• Chromosome Location: Chr.18: 73638998 - 73703741 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Smad4
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_008540.2	NP_032566.2	7 - 8	1339		59
GenBank mRNA	AB221585.1	-	6 - 7	899		59
	AK004804.1	-	6 - 7	703		59
	AY493561.1	-	6 - 7	899		59
	BC046584.1	-	7 - 8	1339	6313280	59
	GU072919.1	-	6 - 7	899		59
	GU072920.1	-	6 - 7	899		59

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC1800001577.mm.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Mammalian Gene Collection, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Smad4

Panther Classification:

Molecular Function -

DNA-binding transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

branching involved in ureteric bud morphogenesis
response to hypoxia
in utero embryonic development
gastrulation with mouth forming second
kidney development
atrioventricular valve formation
epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of cell proliferation involved in heart valve morphogenesis
cardiac septum development
brainstem development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
SMAD protein complex assembly
gastrulation
axon guidance
endoderm development
mesoderm development
cell proliferation
negative regulation of cell proliferation
anterior/posterior pattern specification
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
neural crest cell differentiation
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cell growth
BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
somite rostral/caudal axis specification
regulation of transforming growth factor beta2 production
intracellular signal transduction
atrioventricular canal development
endothelial cell activation
regulation of cell proliferation
negative regulation of protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
developmental growth
neuron fate commitment
tissue morphogenesis
sebaceous gland development
formation of anatomical boundary
regulation of binding
regulation of hair follicle development
palate development
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
negative regulation of cell death
endocardial cell differentiation
response to transforming growth factor beta
metanephric mesenchyme morphogenesis
nephrogenic mesenchyme morphogenesis

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcription factor activity, protein binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
collagen binding
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
filamin binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
SMAD binding
metal ion binding
protein heterodimerization activity
I-SMAD binding
R-SMAD binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR1800011408.mm.1	NM_008540.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1800011408.mm.1	NM_008540.2	Refseq
Affymetrix Mouse Clariom S Array	PSR1800011408.mm.1	TC1800001577.mm.1	MTA TC