Mm00802245_m1

• Gene Symbol: Casp8
• Gene Name: caspase 8
• Gene Aliases: CASP-8, FLICE, MACH, Mch5
• Chromosome Location: Chr.1: 58795229 - 58847503 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Casp8
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001080126.1	NP_001073595.1	6 - 7	892		69
	NM_001277926.1	NP_001264855.1	7 - 8	1008		69
	NM_009812.2	NP_033942.1	6 - 7	1065		69
GenBank mRNA	AF067834.1	-	6 - 7	945		69
	AJ000641.1	-	5 - 6	511		69
	AJ007749.1	-	6 - 7	718		69
	AK146758.1	-	6 - 7	1065		69
	AK153340.1	-	6 - 7	774		69
	AK156135.1	-	6 - 7	781		69
	AK168812.1	-	6 - 7	1065		69
	BC006737.1	-	6 - 7	1007	3964119	69
	BC049955.1	-	6 - 7	899	4208824	69
	CT010166.1	-	5 - 6	672		69

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0100000440.mm.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Apoptosis, Protease, Mammalian Gene Collection, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Casp8

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

angiogenesis
neural tube formation
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
heart development
extrinsic apoptotic signaling pathway via death domain receptors
macrophage differentiation
response to tumor necrosis factor
TRAIL-activated apoptotic signaling pathway
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
response to ethanol
positive regulation of macrophage differentiation
positive regulation of proteolysis
cardiac muscle tissue development
protein heterooligomerization
proteolysis involved in cellular protein catabolic process
negative regulation of necroptotic process
regulation of thymocyte apoptotic process
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
execution phase of apoptosis
activation of cysteine-type endopeptidase activity
hepatocyte apoptotic process
regulation of apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

endopeptidase activity
cysteine-type endopeptidase activity
death receptor binding
tumor necrosis factor receptor binding
protein binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
ubiquitin protein ligase binding
protein complex binding
death effector domain binding
protein heterodimerization activity
scaffold protein binding
cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type endopeptidase activity involved in apoptotic signaling pathway