Mm01149114_g1

• Gene Symbol: Gclc
• Gene Name: glutamate-cysteine ligase, catalytic subunit
• Gene Aliases: D9Wsu168e, GLCL-H, Ggcs-hs, Glclc
• Chromosome Location: Chr.9: 77754516 - 77794489 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Gclc
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_010295.2	NP_034425.1	7 - 8	1107		71
GenBank mRNA	AK144339.1	-	7 - 8	1108		71
	AK160876.1	-	7 - 8	867		71
	AK169676.1	-	7 - 8	1080		71
	BC019374.1	-	7 - 8	864	4195425	71
	U85414.1	-	7 - 8	832		71
	U85498.1	-	7 - 8	832		71

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0900001038.mm.1

• Set Membership: Ambion siRNA available, Amplicon length between 71 and 85, Mammalian Gene Collection, Detect Genomic DNA, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Gclc

Panther Classification:

Molecular Function -

ligase

Gene Ontology Categories:

Process(es)

cysteine metabolic process
glutamate metabolic process
glutathione metabolic process
glutathione biosynthetic process
response to oxidative stress
apoptotic mitochondrial changes
response to heat
response to xenobiotic stimulus
response to hormone
L-ascorbic acid metabolic process
negative regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
cell redox homeostasis
negative regulation of transcription, DNA-templated
response to arsenic-containing substance
regulation of blood vessel size
response to nitrosative stress
regulation of mitochondrial depolarization
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

nucleotide binding
magnesium ion binding
glutamate-cysteine ligase activity
ATP binding
glutamate binding
ligase activity
ADP binding
protein heterodimerization activity
coenzyme binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0900008135.mm.1	NM_010295.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0900008135.mm.1	NM_010295.2	Refseq
Affymetrix Mouse Clariom S Array	PSR0900008135.mm.1	TC0900001038.mm.1	MTA TC