Mm01159248_m1

• Gene Symbol: Ezh2
• Gene Name: enhancer of zeste homolog 2 (Drosophila)
• Gene Aliases: Enx-1, Enx1h, KMT6, mKIAA4065
• Chromosome Location: Chr.6: 47530274 - 47595340 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Ezh2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001146689.1	NP_001140161.1	6 - 7	740		147
	NM_007971.2	NP_031997.2	6 - 7	767		147
GenBank mRNA	AK088575.1	-	6 - 7	761		147
	AK153835.1	-	5 - 6	688		147
	AK157853.1	-	6 - 7	768		147
	AK220174.1	-	6 - 7	722		147
	BC003772.1	-	6 - 7	676	3492110	147
	BC016391.1	-	6 - 7	689	3586689	147
	BC079538.1	-	6 - 7	691	6817366	147
	U52951.1	-	6 - 7	757		147

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0600002200.mm.1

• Set Membership: Ambion siRNA available, Amplicon length greater than or equal to 101, Mammalian Gene Collection, Mus musculus, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Ezh2

Panther Classification:

Molecular Function -

histone modifying enzyme

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
regulation of protein phosphorylation
DNA methylation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
regulation of gene expression
negative regulation of gene expression
positive regulation of epithelial to mesenchymal transition
regulation of gliogenesis
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
chromatin modification
histone methylation
peptidyl-lysine methylation
cerebellar cortex development
methylation
negative regulation of transcription elongation from RNA polymerase II promoter
regulation of cell proliferation
regulation of circadian rhythm
positive regulation of MAP kinase activity
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of GTPase activity
negative regulation of epidermal cell differentiation
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
negative regulation of retinoic acid receptor signaling pathway
rhythmic process
regulation of neurogenesis
negative regulation of striated muscle cell differentiation
cellular response to hydrogen peroxide
G1 to G0 transition
histone H3-K27 methylation
protein localization to chromatin
positive regulation of protein serine/threonine kinase activity
positive regulation of dendrite development
negative regulation of G1/S transition of mitotic cell cycle

Function(s)

regulatory region DNA binding
core promoter binding
chromatin binding
RNA binding
protein binding
methyltransferase activity
protein-lysine N-methyltransferase activity
transferase activity
histone-lysine N-methyltransferase activity
chromatin DNA binding
histone methyltransferase activity
sequence-specific DNA binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0600017328.mm.1	TC0600002200.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0600017328.mm.1	NM_001146689.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0600017328.mm.1	NM_001146689.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0600017328.mm.1	NM_007971.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0600017328.mm.1	NM_007971.2	Refseq
Affymetrix Mouse Clariom S Array	PSR0600017326.mm.1	TC0600002200.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0600017326.mm.1	NM_001146689.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0600017326.mm.1	NM_001146689.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0600017326.mm.1	NM_007971.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0600017326.mm.1	NM_007971.2	Refseq
Affymetrix Mouse Clariom S Array	PSR0600017327.mm.1	TC0600002200.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0600017327.mm.1	NM_001146689.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0600017327.mm.1	NM_001146689.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0600017327.mm.1	NM_007971.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0600017327.mm.1	NM_007971.2	Refseq