Mm03682085_m1

• Gene Symbol: Il4
• Gene Name: interleukin 4
• Gene Aliases: BSF-1, Il-4
• Chromosome Location: Chr.11: 53612460 - 53618665 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Il4
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NR_027491.1		1 - 2	262		74
GenBank mRNA	AA199406.1	-	1 - 2	262		74
	AF359558.1	-	1 - 2	201		74
	BX529138.1	-	1 - 2	271		74

Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Transcript Location	Amplicon Length
GenBankmRNA	AI324371.1	-	1 - 2	100		Chr. 11 - 53612469 - 53617176 [-] on Build GRCm38	74
GenBankmRNA	AA153220.1	-	1 - 2	100		Chr. 11 - 53612474 - 53617176 [-] on Build GRCm38	74
GenBankmRNA	AW988069.1	-	1 - 2	259		Chr. 11 - 53612468 - 53617335 [-] on Build GRCm38	74
GenBankmRNA	AI528678.1	-	2 - 3			Chr. 11 - 53612454 - 53617163 [+] on Build GRCm38	74
GenBankmRNA	AA967539.1	-		262		Chr. - - [-] on Build	74
GenBankmRNA	BE133197.1	-	2 - 3			Chr. 11 - 53612466 - 53617176 [+] on Build GRCm38	74
GenBankmRNA	BY056727.1	-	1 - 2	264		Chr. 11 - 53614000 - 53617338 [-] on Build GRCm38	74
GenBankmRNA	BY412262.1	-	1 - 2			Chr. 11 - 53602982 - 53617224 [-] on Build GRCm38	76

Adjacent Gene Details

	Gene name	Gene Symbol	Alias	Distance	Relative Direction	Location Chromsome
Upstream	kinesin family member 3A	Kif3a	Kif3, Kifl, Kns3	-9.7kb	Anti-sense	Chr. 11 - 53567195 - 53604248 on NCBI Build GRCm38
Downstream	interleukin 13	Il13	Il-13	14.0kb	Sense	Chr. 11 - 53631323 - 53634702 on NCBI Build GRCm38

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC1100002737.mm.1

• Set Membership: Amplicon length between 71 and 85, Mus musculus, Probe spans exons

Gene Ontology Categories:

Process(es)

microglial cell activation
positive regulation of protein phosphorylation
innate immune response in mucosa
positive regulation of defense response to virus by host
T-helper 1 cell lineage commitment
positive regulation of immunoglobulin production
negative regulation of acute inflammatory response
negative regulation of chronic inflammatory response
immune response
cholesterol metabolic process
positive regulation of cell proliferation
regulation of proton transport
negative regulation of epithelial cell migration
positive regulation of B cell proliferation
B cell costimulation
positive regulation of interleukin-10 production
positive regulation of interleukin-13 production
T-helper 2 cell cytokine production
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
B cell activation
positive regulation of tyrosine phosphorylation of Stat5 protein
defense response to protozoan
negative regulation of macrophage activation
positive regulation of mast cell degranulation
negative regulation of nitric oxide biosynthetic process
T-helper 2 cell differentiation
positive regulation of chemokine biosynthetic process
positive regulation of MHC class II biosynthetic process
positive regulation of T cell differentiation
negative regulation of osteoclast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of isotype switching to IgE isotypes
positive regulation of isotype switching to IgG isotypes
regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
regulation of immune response
negative regulation of T cell activation
positive regulation of B cell activation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of mononuclear cell migration
dendritic cell differentiation
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of myoblast fusion
negative regulation of complement-dependent cytotoxicity
negative regulation of T-helper 17 cell differentiation
negative regulation of endothelial cell apoptotic process
positive regulation of eosinophil chemotaxis
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

cytokine activity
cytokine receptor binding
interleukin-4 receptor binding
growth factor activity

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR1100024855.mm.1	NR_027491.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1100024855.mm.1	NR_027491.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1100024855.mm.1	TC1100002737.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR1100024856.mm.1	NR_027491.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1100024856.mm.1	NR_027491.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1100024856.mm.1	TC1100002737.mm.1	MTA TC