Assay Details

Gene Symbol: Il1b
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_031512.2	NP_113700.2	5 - 6	525		74
GenBank mRNA	BC091141.1	-	5 - 6	525	7365029	74
GenBank mRNA	M98820.1	-	5 - 6	545		74

More Information

Updated Mapping Information

This assay targets the same location as RTA transcript cluster(s) TC0300004147.rn.1

Set Membership:

Ambion siRNA available

Amplicon length between 71 and 85

Mammalian Gene Collection

Recommended Assay

Rattus norvegicus

Rat Chemokine Panel

Rat Tumor Metastasis Panel

Inventoried

Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Il1b

Panther Classification:

Molecular Function -

interleukin superfamily

Gene Ontology Categories:

Function(s) Process(es)

MicroArray Probes:

Affymetrix

Citations (40)

Selective portal vein embolization and ligation trigger different regenerative responses in the rat liver.

Authors: Furrer K, Tian Y, Pfammatter T, Jochum W, El-Badry AM, Graf R, Clavien PA
Journal: Hepatology - Page No 1615 (Thu May 01 00:00:00 EDT 2008)
Volume (Year): 47 (2008)
Product Usage: -

Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells.

Authors: Karger A, Fitzner B, Brock P, Sparmann G, Emmrich J, Liebe S, Jaster R
Journal: Cell Signal - Page No 1865 (Wed Oct 01 00:00:00 EDT 2008)
Volume (Year): 20 (2008)
Product Usage: -

Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells.

Authors: Ribaux P, Ehses JA, Lin-Marq N, Carrozzino F, Boni-Schnetzler M, Hammar E, Irminger JC, Donath MY, Halban PA
Journal: Endocrinology - Page No 5582 (Thu Nov 01 00:00:00 EDT 2007)
Volume (Year): 148 (2007)
Product Usage: -

Lineage-negative bone marrow cells protect against chronic renal failure.

Authors: Alexandre CS, Volpini RA, Shimizu MH, Sanches TR, Semedo P, di Jura VL, Camara NO, Seguro AC, Andrade L
Journal: Stem Cells - Page No 682 (Sun Mar 01 00:00:00 EST 2009)
Volume (Year): 27 (2009)
Product Usage: -

JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat.

Authors: Dominguez E, Rivat C, Pommier B, Mauborgne A, Pohl M
Journal: J Neurochem - Page No 50 (Wed Oct 01 00:00:00 EDT 2008)
Volume (Year): 107 (2008)
Product Usage: -

Inchinkoto, an herbal medicine, exerts beneficial effects in the rat liver under stress with hepatic ischemia-reperfusion and subsequent hepatectomy.

Authors: Kawai K, Yokoyama Y, Kokuryo T, Watanabe K, Kitagawa T, Nagino M
Journal: Ann Surg - Page No 692 (Thu Apr 01 00:00:00 EDT 2010)
Volume (Year): 251 (2010)
Product Usage: -

Retinoic acid therapy attenuates the severity of tuberculosis while altering lymphocyte and macrophage numbers and cytokine expression in rats infected with Mycobacterium tuberculosis.

Authors: Yamada H, Mizuno S, Ross AC, Sugawara I
Journal: J Nutr - Page No 2696 (Sat Dec 01 00:00:00 EST 2007)
Volume (Year): 137 (2007)
Product Usage: -

Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemia.

Authors: Borge BA, Kalland KH, Olsen S, Bletsa A, Berggreen E, Wiig H
Journal: Am J Physiol Heart Circ Physiol - Page No H735 (Sun Mar 01 00:00:00 EST 2009)
Volume (Year): 296 (2009)
Product Usage: -

The peptide NDP-MSH induces phenotype changes in the heart that resemble ischemic preconditioning.

Authors: Catania A, Lonati C, Sordi A, Leonardi P, Carlin A, Gatti S
Journal: Peptides - Page No 116 (Fri Jan 01 00:00:00 EST 2010)
Volume (Year): 31 (2010)
Product Usage: -

Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro.

Authors: Lyons A, Lynch AM, Downer EJ, Hanley R, O'Sullivan JB, Smith A, Lynch MA
Journal: J Neurochem - Page No 1547 (Tue Sep 01 00:00:00 EDT 2009)
Volume (Year): 110 (2009)
Product Usage: -

Molecular signatures of trauma-hemorrhagic shock-induced lung injury: hemorrhage- and injury-associated genes.

Authors: Feinman R, Deitch EA, Aris V, Chu HB, Abungu B, Caputo FJ, Galante A, Xu D, Lu Q, Colorado I, Streck D, Dermody J, Soteropoulos P
Journal: Shock - Page No 360 (Sat Sep 01 00:00:00 EDT 2007)
Volume (Year): 28 (2007)
Product Usage: -

Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis.

Authors: Marchalant Y, Brothers HM, Norman GJ, Karelina K, DeVries AC, Wenk GL
Journal: Neurobiol Dis - Page No 300 (Fri May 01 00:00:00 EDT 2009)
Volume (Year): 34 (2009)
Product Usage: -

Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis.

Authors: Funk JL, Frye JB, Oyarzo JN, Kuscuoglu N, Wilson J, McCaffrey G, Stafford G, Chen G, Lantz RC, Jolad SD, Solyom AM, Kiela PR, Timmermann BN
Journal: Arthritis Rheum - Page No 3452 (Wed Nov 01 00:00:00 EST 2006)
Volume (Year): 54 (2006)
Product Usage: -

Rutin supplementation in the diet has protective effects against toxicant-induced hippocampal injury by suppression of microglial activation and pro-inflammatory cytokines: protective effect of rutin against toxicant-induced hippocampal injury.

Authors: Koda T, Kuroda Y, Imai H
Journal: Cell Mol Neurobiol - Page No 523 (Mon Jun 01 00:00:00 EDT 2009)
Volume (Year): 29 (2009)
Product Usage: -

SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury.

Authors: Dominguez E, Mauborgne A, Mallet J, Desclaux M, Pohl M
Journal: J Neurosci - Page No 5754 (Wed Apr 21 00:00:00 EDT 2010)
Volume (Year): 30 (2010)
Product Usage: -

Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression.

Authors: Piepoli T, Mennuni L, Zerbi S, Lanza M, Rovati LC, Caselli G
Journal: Osteoarthritis Cartilage - Page No 1076 (Sat Aug 01 00:00:00 EDT 2009)
Volume (Year): 17 (2009)
Product Usage: -

Differential implication of proinflammatory cytokine interleukin-6 in the development of cephalic versus extracephalic neuropathic pain in rats.

Authors: Latremoliere A, Mauborgne A, Masson J, Bourgoin S, Kayser V, Hamon M, Pohl M
Journal: J Neurosci - Page No 8489 (Wed Aug 20 00:00:00 EDT 2008)
Volume (Year): 28 (2008)
Product Usage: -

Inflammatory responses in aggregating rat brain cell cultures subjected to different demyelinating conditions.

Authors: Defaux A, Zurich MG, Honegger P, Monnet-Tschudi F
Journal: Brain Res - Page No 213 (Fri Sep 24 00:00:00 EDT 2010)
Volume (Year): 1353 (2010)
Product Usage: -

Perioperative infliximab application ameliorates acute rejection associated inflammation after intestinal transplantation.

Authors: Pech T, Finger T, Fujishiro J, Praktiknjo M, Ohsawa I, Abu-Elmagd K, Limmer A, Hirner A, Kalff JC, Schaefer N
Journal: Am J Transplant - Page No 2431 (Mon Nov 01 00:00:00 EDT 2010)
Volume (Year): 10 (2010)
Product Usage: -

The beta2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity.

Authors: Gleeson LC, Ryan KJ, Griffin EW, Connor TJ, Harkin A
Journal: Brain Behav Immun - Page No 1354 (Mon Nov 01 00:00:00 EDT 2010)
Volume (Year): 24 (2010)
Product Usage: -

Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex.

Authors: McNamee EN, Griffin EW, Ryan KM, Ryan KJ, Heffernan S, Harkin A, Connor TJ
Journal: Neuropharmacology - Page No 37 (Thu Jul 01 00:00:00 EDT 2010)
Volume (Year): 59 (2010)
Product Usage: -

Dietary supplementation of tetradecylthioacetic acid increases feed intake but reduces body weight gain and adipose depot sizes in rats fed on high-fat diets.

Authors: Wensaas AJ, Rustan AC, Rokling-Andersen MH, Caesar R, Jensen J, Kaalhus O, Graff BA, Gudbrandsen OA, Berge RK, Drevon CA
Journal: Diabetes Obes Metab - Page No 1034 (Sun Nov 01 00:00:00 EDT 2009)
Volume (Year): 11 (2009)
Product Usage: -

Cadmium-induced inflammatory responses in cells relevant for lung toxicity: Expression and release of cytokines in fibroblasts, epithelial cells and macrophages.

Authors: Lag M, Rodionov D, Ovrevik J, Bakke O, Schwarze PE, Refsnes M
Journal: Toxicol Lett - Page No 252 (Thu Apr 01 00:00:00 EDT 2010)
Volume (Year): 193 (2010)
Product Usage: -

AAV2/1-TNFR:Fc gene delivery prevents periodontal disease progression.

Authors: Cirelli JA, Park CH, MacKool K, Taba M Jr, Lustig KH, Burstein H, Giannobile WV
Journal: Gene Ther - Page No 426 (Sun Mar 01 00:00:00 EST 2009)
Volume (Year): 16 (2009)
Product Usage: -

Acute starvation alters lipopolysaccharide-induced fever in leptin-dependent and -independent mechanisms in rats.

Authors: Inoue W, Luheshi GN
Journal: Am J Physiol Regul Integr Comp Physiol - Page No R1709 (Wed Dec 01 00:00:00 EST 2010)
Volume (Year): 299 (2010)
Product Usage: -

Mechanisms involved in ultrafine carbon black-induced release of IL-6 from primary rat epithelial lung cells.

Authors: Totlandsdal AI, Refsnes M, Lag M
Journal: Toxicol In Vitro - Page No 10 (Mon Feb 01 00:00:00 EST 2010)
Volume (Year): 24 (2010)
Product Usage: -

Systemic immune challenge activates an intrinsically regulated local inflammatory circuit in the adrenal gland.

Authors: Engstrom L, Rosen K, Angel A, Fyrberg A, Mackerlova L, Konsman JP, Engblom D, Blomqvist A
Journal: Endocrinology - Page No 1436 (Tue Apr 01 00:00:00 EDT 2008)
Volume (Year): 149 (2008)
Product Usage: -

Pro-inflammatory potential of ultrafine particles in mono- and co-cultures of primary cardiac cells.

Authors: Totlandsdal AI, Skomedal T, Lag M, Osnes JB, Refsnes M
Journal: Toxicology - Page No 23 (Fri May 02 00:00:00 EDT 2008)
Volume (Year): 247 (2008)
Product Usage: -

Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling.

Authors: Kohno T, Anzai T, Naito K, Miyasho T, Okamoto M, Yokota H, Yamada S, Maekawa Y, Takahashi T, Yoshikawa T, Ishizaka A, Ogawa S
Journal: Cardiovasc Res - Page No 565 (Sun Feb 15 00:00:00 EST 2009)
Volume (Year): 81 (2009)
Product Usage: -

The role of proliferator-activated receptor gamma coactivator-1alpha in the fatty-acid-dependent transcriptional control of interleukin-10 in hepatic cells of rodents.

Authors: Morari J, Torsoni AS, Anhe GF, Roman EA, Cintra DE, Ward LS, Bordin S, Velloso LA
Journal: Metabolism - Page No 215 (Mon Feb 01 00:00:00 EST 2010)
Volume (Year): 59 (2010)
Product Usage: -

Segmental cholangitis impairs hepatic regeneration capacity after partial hepatectomy in rats.

Authors: Watanabe K, Yokoyama Y, Kokuryo T, Kawai K, Kitagawa T, Seki T, Nakagawa A, Nagino M
Journal: Hpb (Oxford) - Page No 664 (Wed Dec 01 00:00:00 EST 2010)
Volume (Year): 12 (2010)
Product Usage: -

Molecular determinants of the profibrogenic effects of endothelin-1 in pancreatic stellate cells.

Authors: Jonitz A, Fitzner B, Jaster R
Journal: World J Gastroenterol - Page No 4143 (Mon Sep 07 00:00:00 EDT 2009)
Volume (Year): 15 (2009)
Product Usage: -

Influence of mast cells on outcome after heterotopic cardiac transplantation in rats.

Authors: Boerma M, Fiser WP, Hoyt G, Berry GJ, Joseph L, Joseph J, Wang J, Crew MD, Robbins RC, Hauer-Jensen M
Journal: Transpl Int - Page No 256 (Thu Mar 01 00:00:00 EST 2007)
Volume (Year): 20 (2007)
Product Usage: -

Deleterious effects of dihydrotestosterone on cerebral ischemic injury.

Authors: Cheng J, Alkayed NJ, Hurn PD
Journal: J Cereb Blood Flow Metab - Page No 1553 (Sat Sep 01 00:00:00 EDT 2007)
Volume (Year): 27 (2007)
Product Usage: -

Evidence for Activation of Inflammatory Lipoxygenase Pathways in Visceral Adipose Tissue of Obese Zucker Rats.

Authors: Chakrabarti SK, Wen Y, Dobrian AD, Cole BK, Ma Q, Pei H, Williams MD, Bevard MH, Vandenhoff GE, Keller SR, Gu J, Nadler JL
Journal: Am J Physiol Endocrinol Metab - Page No (Tue Oct 26 00:00:00 EDT 2010)
Volume (Year): (2010)
Product Usage: -

Effect of partial hydrolysis of octacalcium phosphate on its osteoconductive characteristics.

Authors: Miyatake N, Kishimoto KN, Anada T, Imaizumi H, Itoi E, Suzuki O
Journal: Biomaterials - Page No 1005 (Sun Feb 01 00:00:00 EST 2009)
Volume (Year): 30 (2009)
Product Usage: -

Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide.

Authors: Lyons A, McQuillan K, Deighan BF, O'Reilly JA, Downer EJ, Murphy AC, Watson M, Piazza A, O'Connell F, Griffin R, Mills KH, Lynch MA
Journal: Brain Behav Immun - Page No 1020 (Thu Oct 01 00:00:00 EDT 2009)
Volume (Year): 23 (2009)
Product Usage: -

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.

Authors: Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Tsukumo DM, Anhe G, Amaral ME, Takahashi HK, Curi R, Oliveira HC, Carvalheira JB, Bordin S, Saad MJ, Velloso LA
Journal: J Neurosci - Page No 359 (Wed Jan 14 00:00:00 EST 2009)
Volume (Year): 29 (2009)
Product Usage: -

Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity.

Authors: McNamee EN, Ryan KM, Kilroy D, Connor TJ
Journal: Eur J Pharmacol - Page No 219 (Mon Jan 25 00:00:00 EST 2010)
Volume (Year): 626 (2010)
Product Usage: -

Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes.

Authors: Canellada A, Ramirez BG, Minami T, Redondo JM, Cano E
Journal: Glia - Page No 709 (Thu May 01 00:00:00 EDT 2008)
Volume (Year): 56 (2008)
Product Usage: -

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