Rn00581264_m1

• Gene Symbol: Map2k1
• Gene Name: mitogen activated protein kinase kinase 1
• Gene Aliases: Mek1
• Chromosome Location: Chr.8: 69134218 - 69722252 on Build Rnor_6.0
• Species: Rat
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Map2k1
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_031643.4	NP_113831.1	1 - 2	130		70
GenBank mRNA	AI603089.1	-	1 - 2	130		70
	BC089772.1	-	1 - 2	124	7382030	70
	D13341.1	-	1 - 2	113		70
	D14591.1	-	1 - 2	83		70
	X62313.1	-	1 - 2	120		70
	Z16415.1	-	1 - 2	113		70

More Information

Updated Mapping Information

This assay targets the same location as RTA transcript cluster(s) TC0800002747.rn.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Protein Kinase, Mammalian Gene Collection, Rattus norvegicus, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Map2k1

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPK activity
regulation of vascular smooth muscle contraction
protein phosphorylation
response to oxidative stress
cell cycle arrest
mitotic nuclear division
cell proliferation
negative regulation of cell proliferation
positive regulation of gene expression
peptidyl-tyrosine phosphorylation
neuron differentiation
keratinocyte differentiation
positive regulation of cell migration
melanosome transport
regulation of stress-activated MAPK cascade
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of homotypic cell-cell adhesion
peptidyl-tyrosine dephosphorylation
intracellular signal transduction
positive regulation of GTPase activity
positive regulation of cell differentiation
positive regulation of Ras protein signal transduction
vesicle transport along microtubule
Golgi inheritance
response to axon injury
regulation of axon regeneration
neuron projection morphogenesis
cell motility
positive regulation of axonogenesis
protein heterooligomerization
response to glucocorticoid
lung morphogenesis
trachea formation
epithelial cell proliferation involved in lung morphogenesis
placenta blood vessel development
labyrinthine layer development
ERK1 and ERK2 cascade
positive regulation of protein serine/threonine kinase activity
regulation of Golgi inheritance
cellular senescence
regulation of early endosome to late endosome transport

Function(s)

protein serine/threonine kinase activity
MAP kinase kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
receptor signaling protein tyrosine phosphatase activity
protein binding
ATP binding
Ras GTPase binding
protein kinase binding
mitogen-activated protein kinase kinase kinase binding
protein serine/threonine kinase activator activity

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Rat Clariom S Assay	PSR0800022348.rn.1	TC0800002747.rn.1	RTA TC
Affymetrix Rat Clariom S Assay	PSR0800022352.rn.1	TC0800002747.rn.1	RTA TC
Affymetrix Rat Clariom S Assay	PSR0800022347.rn.1	TC0800002747.rn.1	RTA TC
Affymetrix Rat Clariom S Assay	PSR0800022351.rn.1	TC0800002747.rn.1	RTA TC