Rn01410330_m1 Best Coverage

• Gene Symbol: Il6
• Gene Name: interleukin 6
• Gene Aliases: ILg6, Ifnb2
• Chromosome Location: Chr.4: 3043231 - 3047807 on Build Rnor_6.0
• Species: Rat
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Il6
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_012589.2	NP_036721.1	3 - 4	383		121
GenBank mRNA	M26744.1	-	3 - 4	383		121

More Information

Updated Mapping Information

This assay targets the same location as RTA transcript cluster(s) TC0400000061.rn.1

• Set Membership: Ambion siRNA available, Amplicon length greater than or equal to 101, Apoptosis, 3' Most, Recommended Assay, Rattus norvegicus, 1700, Inventoried, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Il6

Gene Ontology Categories:

Process(es)

neutrophil apoptotic process
response to yeast
myeloid cell homeostasis
hepatic immune response
positive regulation of acute inflammatory response
negative regulation of protein kinase activity
acute-phase response
inflammatory response
aging
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell shape
response to heat
response to cold
response to wounding
response to mechanical stimulus
response to bacterium
regulation of vascular endothelial growth factor production
positive regulation of gene expression
response to auditory stimulus
response to organic cyclic compound
cell growth
cytokine-mediated signaling pathway
response to caffeine
endocrine pancreas development
neuron projection development
response to nutrient levels
response to peptidoglycan
response to lipopolysaccharide
positive regulation of chemokine production
positive regulation of interleukin-6 production
response to insulin
negative regulation of collagen biosynthetic process
positive regulation of peptidyl-serine phosphorylation
positive regulation of protein import into nucleus, translocation
response to cytokine
wound healing
positive regulation of T cell proliferation
T cell activation
regulation of cell proliferation
response to drug
positive regulation of tyrosine phosphorylation of Stat3 protein
glucose homeostasis
defense response to protozoan
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to amino acid
positive regulation of MAPK cascade
negative regulation of chemokine biosynthetic process
regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of nitric oxide biosynthetic process
cell redox homeostasis
positive regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
negative regulation of gluconeogenesis
positive regulation of translation
positive regulation of DNA replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
response to antibiotic
muscle cell cellular homeostasis
bone remodeling
negative regulation of hormone secretion
negative regulation of muscle organ development
positive regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
negative regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of B cell activation
positive regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
response to glucocorticoid
response to calcium ion
response to electrical stimulus
defense response to virus
positive regulation of protein kinase B signaling
positive regulation of transmission of nerve impulse
branching involved in salivary gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
glucagon secretion
interleukin-6-mediated signaling pathway
cellular response to hydrogen peroxide
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to dexamethasone stimulus
T-helper 17 cell lineage commitment
negative regulation of neuron death

Function(s)

receptor binding
cytokine activity
interleukin-6 receptor binding
growth factor activity

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Agilent Whole Rat Genome Microarray 4x44K v2	A_44_P371339	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	66784	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	67564	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	67977	-	-
Agilent SurePrint G3 Rat CGH Microarray 4x180K	128181	-	-
Agilent Whole Rat Genome Microarray 4x44K v3	A_44_P371339	-	-
Agilent Whole Rat Genome Microarray 4x44K v3	A_44_P371339	-	-
Agilent SurePrint G3 Rat GE 8x60K Microarray	A_44_P371339	-	-
SurePrint G3 Rat Gene Expression Microarray G4131A	A_44_P371339	-	-
Agilent Rat Genome CGH Microarray 105A (G4436A)	77452	-	-

Array Name	Probe IDs	Targets	Target Type
Affymetrix Rat Gene 1.0 ST Array	10859801	-	-
Affymetrix Rat Gene 1.0 ST Array	10859800	-	-
Affymetrix Rat Gene 1.0 ST Array	10859803	-	-
Affymetrix Rat Gene 1.0 ST Array	10859804	-	-
Affymetrix Rat Gene 1.0 ST Array	10859802	-	-
Affymetrix Rat Gene 1.1 ST Array	10859799	-	-
Rat Genome 230 2.0 Array	1369191_PM_at	-	-
Rat Genome 230 2.0 Array	1369191_at	-	-
Affymetrix HT Rat Focus Array	1369191_at	-	-
Affymetrix HT Rat Focus Array	1369191_PM_at	-	-
Affymetrix Rat Clariom S Assay	PSR0400000332.rn.1	TC0400000061.rn.1	RTA TC
Affymetrix Rat Clariom S Assay	PSR0400000331.rn.1	TC0400000061.rn.1	RTA TC
Rat Expression Set 230	1369191_PM_at	-	-
Rat Expression Set 230	1369191_at	-	-
Affymetrix Rat Gene 1.0 ST Array	10859799	-	-
Rat Genome U34 Set	M26744_at	-	-
Rat Genome U34 Set	M26745cds_s_at	-	-
Rat Genome U34 Set	M26744_at	-	-
Rat Genome U34 Set	M26745cds_s_at	-	-
Rat Genome U34 Set	M26745cds_s_at	-	-
Rat Genome U34 Set	M26744_at	-	-

Array Name	Probe IDs	Targets	Target Type
ABI Rat Genome Survey Microarray	22130479	-	-

Array Name	Probe IDs	Targets	Target Type
Illumina ratRef-12 v1.0 expression beadchip	ILMN_1355154	-	-
RatRef-12 Expression BeadChip	ILMN_52428	-	-