Rn01448881_m1

• Gene Symbol: Lyn
• Gene Name: LYN proto-oncogene, Src family tyrosine kinase
• Gene Aliases: p53Lyn, p56Lyn
• Chromosome Location: Chr.5: 16526058 - 16642648 on Build Rnor_6.0
• Species: Rat
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Lyn
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001111098.1	NP_001104568.1	6 - 7	648		136
	NM_030857.2	NP_110484.1	6 - 7	711		136
	XM_006237834.2	XP_006237896.1	6 - 7	1027		136
GenBank mRNA	AF000300.1	-	6 - 7	556		136
	AF000301.1	-	6 - 7	648		136
	AF000302.1	-	6 - 7	646		136
	L14951.1	-	6 - 7	714		136

More Information

Updated Mapping Information

This assay targets the same location as RTA transcript cluster(s) TC0500000129.rn.1

• Set Membership: Ambion siRNA available, Amplicon length greater than or equal to 101, Protein Kinase, Rattus norvegicus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Lyn

Gene Ontology Categories:

Process(es)

B cell homeostasis
regulation of cytokine production
negative regulation of protein phosphorylation
Fc receptor mediated stimulatory signaling pathway
tolerance induction to self antigen
histamine secretion by mast cell
platelet degranulation
negative regulation of myeloid leukocyte differentiation
immune response-regulating cell surface receptor signaling pathway
Fc receptor mediated inhibitory signaling pathway
regulation of B cell apoptotic process
protein phosphorylation
chemotaxis
cellular response to DNA damage stimulus
response to sterol depletion
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
negative regulation of cell proliferation
response to toxic substance
response to hormone
response to carbohydrate
positive regulation of neuron projection development
oligodendrocyte development
response to organic cyclic compound
cell migration
peptidyl-tyrosine phosphorylation
hemopoiesis
erythrocyte differentiation
positive regulation of cell migration
negative regulation of B cell proliferation
neuron projection development
lipopolysaccharide-mediated signaling pathway
cellular response to extracellular stimulus
response to insulin
regulation of mast cell activation
regulation of cell adhesion mediated by integrin
negative regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
cellular response to heat
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
positive regulation of phosphorylation
response to drug
positive regulation of tyrosine phosphorylation of STAT protein
response to amino acid
regulation of mast cell degranulation
negative regulation of MAP kinase activity
response to peptide hormone
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
regulation of erythrocyte differentiation
protein autophosphorylation
response to axon injury
cytokine secretion
regulation of cytokine secretion
regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
B cell receptor signaling pathway
regulation of B cell receptor signaling pathway
positive regulation of B cell receptor signaling pathway
positive regulation of cellular component movement
regulation of release of sequestered calcium ion into cytosol
positive regulation of glial cell proliferation
positive regulation of Fc receptor mediated stimulatory signaling pathway
positive regulation of stress-activated protein kinase signaling cascade
regulation of ERK1 and ERK2 cascade
negative regulation of ERK1 and ERK2 cascade
positive regulation of oligodendrocyte progenitor proliferation
negative regulation of mast cell proliferation
positive regulation of mast cell proliferation
cellular response to retinoic acid
cellular response to peptide hormone stimulus
regulation of monocyte chemotaxis
regulation of platelet aggregation
dendritic cell differentiation
negative regulation of intracellular signal transduction
positive regulation of dendritic cell apoptotic process

Function(s)

protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
platelet-derived growth factor receptor binding
integrin binding
protein binding
ATP binding
kinase activity
SH3 domain binding
enzyme binding
ubiquitin protein ligase binding
protein complex binding
gamma-tubulin binding
glycosphingolipid binding
ion channel binding
phosphoprotein binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Rat Clariom S Assay	PSR0500000878.rn.1	TC0500000129.rn.1	RTA TC