Rn01476368_m1

• Gene Symbol: Apoe
• Gene Name: apolipoprotein E
• Gene Aliases: APOEA
• Chromosome Location: Chr.1: 80612894 - 80616820 on Build Rnor_6.0
• Species: Rat
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Apoe
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001270684.1	NP_001257613.1	1 - 2	49		69

More Information

Updated Mapping Information

This assay targets the same location as RTA transcript cluster(s) TC0100004935.rn.1

Additional Information:

This assay is in the 5'UTR region of the NM_001270684.1 transcripts.

• Set Membership: Amplicon length less than or equal to 70, Rattus norvegicus, Probe spans exons

Gene Ontology Categories:

Process(es)

negative regulation of endothelial cell proliferation
response to dietary excess
lipid metabolic process
triglyceride metabolic process
cholesterol biosynthetic process
cholesterol catabolic process
lipid transport
cellular calcium ion homeostasis
receptor-mediated endocytosis
response to oxidative stress
G protein-coupled receptor signaling pathway
nitric oxide mediated signal transduction
aging
protein localization
cholesterol metabolic process
regulation of gene expression
negative regulation of platelet activation
positive regulation of cholesterol esterification
positive regulation of cholesterol efflux
peripheral nervous system axon regeneration
long-chain fatty acid transport
protein import
triglyceride catabolic process
cGMP-mediated signaling
negative regulation of blood coagulation
neuron projection regeneration
axon regeneration
regulation of cholesterol transport
regulation of Cdc42 protein signal transduction
response to retinoic acid
positive regulation of low-density lipoprotein particle receptor catabolic process
response to insulin
cholesterol efflux
phospholipid efflux
very-low-density lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
chylomicron remnant clearance
high-density lipoprotein particle clearance
very-low-density lipoprotein particle clearance
lipoprotein metabolic process
lipoprotein biosynthetic process
lipoprotein catabolic process
vasodilation
cholesterol homeostasis
positive regulation of catalytic activity
negative regulation of MAP kinase activity
negative regulation of neuron apoptotic process
negative regulation of blood vessel endothelial cell migration
reverse cholesterol transport
response to ethanol
negative regulation of cholesterol biosynthetic process
positive regulation of axon extension
positive regulation of lipid biosynthetic process
oligodendrocyte differentiation
artery morphogenesis
negative regulation of inflammatory response
positive regulation of nitric-oxide synthase activity
positive regulation of membrane protein ectodomain proteolysis
negative regulation of lipid biosynthetic process
maintenance of location in cell
lipid homeostasis
fatty acid homeostasis
positive regulation of dendritic spine development
negative regulation of dendritic spine development
cellular response to interleukin-1
cellular response to growth factor stimulus
cellular response to cholesterol
circulatory system development
negative regulation of cholesterol efflux
AMPA glutamate receptor clustering
NMDA glutamate receptor clustering
regulation of amyloid-beta clearance
regulation of neuron death
negative regulation of neuron death
positive regulation of neuron death
negative regulation of postsynaptic membrane organization
positive regulation of postsynaptic membrane organization
negative regulation of presynaptic membrane organization
positive regulation of presynaptic membrane organization
positive regulation of amyloid-beta formation
negative regulation of amyloid-beta formation
regulation of tau-protein kinase activity
negative regulation of dendritic spine maintenance
positive regulation of dendritic spine maintenance
positive regulation of phospholipid efflux
positive regulation of neurofibrillary tangle assembly
negative regulation of phospholipid efflux
negative regulation of lipid transport across blood-brain barrier
positive regulation of lipid transport across blood-brain barrier

Function(s)

amyloid-beta binding
signaling receptor binding
lipid transporter activity
phospholipid binding
heparin binding
lipid binding
cholesterol binding
antioxidant activity
identical protein binding
protein homodimerization activity
hydroxyapatite binding
metal chelating activity
tau protein binding
low-density lipoprotein particle receptor binding
phosphatidylcholine-sterol O-acyltransferase activator activity
very-low-density lipoprotein particle receptor binding
lipoprotein particle binding
cholesterol transfer activity

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Rat Clariom S Assay	PSR0100039025.rn.1	TC0100004935.rn.1	RTA TC
Affymetrix Rat Clariom S Assay	PSR0100039028.rn.1	TC0100004935.rn.1	RTA TC