Rn01491434_m1

• Gene Symbol: Cd74
• Gene Name: Cd74 molecule, major histocompatibility complex, class II invariant chain
• Gene Aliases: INVG34
• Chromosome Location: Chr.18: 56071420 - 56080851 on Build Rnor_6.0
• Species: Rat
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Cd74
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_013069.2	NP_037201.1	6 - 7	673		67
GenBank mRNA	BC059152.1	-	6 - 7	654	6890709	67
	FQ219430.1	-	6 - 7	656		67
	FQ225098.1	-	6 - 7	648		67
	FQ225666.1	-	4 - 5	292		67
	FQ227357.1	-	6 - 7	650		67
	FQ227561.1	-	6 - 7	657		67
	FQ228116.1	-	6 - 7	656		67
	FQ231756.1	-	6 - 7	657		67
	FQ232412.1	-	6 - 7	698		67
	FQ232423.1	-	6 - 7	687		67
	FQ232867.1	-	6 - 7	657		67
	FQ232996.1	-	6 - 7	650		67
	FQ234457.1	-	6 - 7	659		67
	X13044.1	-	6 - 7	629		67

More Information

Updated Mapping Information

This assay targets the same location as RTA transcript cluster(s) TC1800000616.rn.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Mammalian Gene Collection, Rattus norvegicus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Cd74

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

activation of MAPK activity
prostaglandin biosynthetic process
positive regulation of cytokine-mediated signaling pathway
positive regulation of dendritic cell antigen processing and presentation
negative regulation of peptide secretion
positive regulation of type 2 immune response
negative regulation of mature B cell apoptotic process
protein complex assembly
intracellular protein transport
defense response
signal transduction
cell proliferation
immunoglobulin mediated immune response
cytokine-mediated signaling pathway
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of B cell proliferation
macrophage migration inhibitory factor signaling pathway
negative regulation of apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
positive thymic T cell selection
negative thymic T cell selection
negative regulation of T cell differentiation
positive regulation of T cell differentiation
positive regulation of fibroblast proliferation
positive regulation of peptidyl-tyrosine phosphorylation
chaperone mediated protein folding requiring cofactor
positive regulation of macrophage cytokine production
positive regulation of ERK1 and ERK2 cascade
positive regulation of neutrophil chemotaxis
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of chemokine (C-X-C motif) ligand 2 production

Function(s)

beta-amyloid binding
cytokine receptor activity
cytokine binding
MHC class II protein complex binding
macrophage migration inhibitory factor binding
MHC class II protein binding
MHC class II protein binding, via antigen binding groove
protein binding involved in protein folding
nitric-oxide synthase binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Rat Clariom S Assay	PSR1800004497.rn.1	TC1800000616.rn.1	RTA TC