Rn04244522_g1

• Gene Symbol: Ptpn11
• Gene Name: protein tyrosine phosphatase, non-receptor type 11
• Gene Aliases: Shp2
• Chromosome Location: Chr.12: 40895515 - 40955999 on Build Rnor_6.0
• Species: Rat
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Ptpn11
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001177593.1	NP_001171064.1	15 - 16	1987		99
	NM_013088.2	NP_037220.2	15 - 16	1975		99
GenBank mRNA	U09307.1	-	15 - 16	1900		99

More Information

Updated Mapping Information

This assay targets the same location as RTA transcript cluster(s) TC1200000673.rn.1

• Set Membership: Ambion siRNA available, Amplicon length between 86 and 100, Protein Phosphatase, 3' Most, Detect Genomic DNA, Rattus norvegicus, 1700, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Ptpn11

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

DNA damage checkpoint
activation of MAPK activity
protein dephosphorylation
lipid metabolic process
triglyceride metabolic process
epidermal growth factor receptor signaling pathway
integrin-mediated signaling pathway
axonogenesis
brain development
heart development
hormone-mediated signaling pathway
positive regulation of signal transduction
dephosphorylation
platelet formation
microvillus organization
abortive mitotic cell cycle
regulation of cell adhesion mediated by integrin
negative regulation of cell adhesion mediated by integrin
multicellular organism growth
organ growth
peptidyl-tyrosine dephosphorylation
megakaryocyte development
atrioventricular canal development
ERBB signaling pathway
regulation of multicellular organism growth
hormone metabolic process
glucose homeostasis
positive regulation of mitotic cell cycle
negative regulation of insulin secretion
regulation of protein export from nucleus
positive regulation of hormone secretion
negative regulation of hormone secretion
platelet-derived growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
ephrin receptor signaling pathway
multicellular organismal reproductive process
genitalia development
inner ear development
homeostasis of number of cells within a tissue
negative regulation of cortisol secretion
negative regulation of growth hormone secretion
face morphogenesis
intestinal epithelial cell migration
positive regulation of ERK1 and ERK2 cascade
positive regulation of glucose import in response to insulin stimulus

Function(s)

phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
SH3/SH2 adaptor activity
insulin receptor binding
protein binding
protein domain specific binding
receptor tyrosine kinase binding
D1 dopamine receptor binding
phospholipase binding
insulin receptor substrate binding
peptide hormone receptor binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Agilent Whole Rat Genome Microarray 4x44K v2	A_64_P004151	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	838925	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	557762	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	74958	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	660239	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	554172	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	145967	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	515180	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	866569	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	24192	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	903977	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	662194	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	515883	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	327578	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	59517	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	425510	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	856286	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	758266	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	325549	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	349230	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	388356	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	635062	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	646539	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	654457	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	304063	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	464121	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	951327	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	928916	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	110248	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	206182	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	167006	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	319066	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	780893	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	334268	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	960388	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	304258	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	528911	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	654286	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	767127	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	16033	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	728719	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	490653	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	106489	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	191050	-	-
Agilent SurePrint G3 Rat CGH Microarray 1x1M	821497	-	-
Agilent SurePrint G3 Rat CGH Microarray 4x180K	154879	-	-
Agilent SurePrint G3 Rat CGH Microarray 4x180K	128013	-	-
Agilent SurePrint G3 Rat CGH Microarray 4x180K	140073	-	-
Agilent SurePrint G3 Rat CGH Microarray 4x180K	142734	-	-
Agilent SurePrint G3 Rat CGH Microarray 4x180K	108529	-	-
Agilent SurePrint G3 Rat CGH Microarray 4x180K	170416	-	-
Agilent Whole Rat Genome Microarray 4x44K v3	A_64_P004151	-	-
Agilent Whole Rat Genome Microarray 4x44K v3	A_64_P004151	-	-
Agilent SurePrint G3 Rat GE 8x60K Microarray	A_64_P004151	-	-
SurePrint G3 Rat Gene Expression Microarray G4131A	A_44_P317773	-	-
SurePrint G3 Rat Gene Expression Microarray G4131A	A_44_P999869	-	-
Matsumoto (Agilent Rat cDNA Microarray G4105A)	701749110	-	-
Agilent Rat Genome CGH Microarray 105A (G4436A)	94344	-	-
Agilent Rat Genome CGH Microarray 105A (G4436A)	46030	-	-
Agilent Rat Genome CGH Microarray 105A (G4436A)	7314	-	-
Agilent Rat Genome CGH Microarray 105A (G4436A)	3675	-	-
Agilent Rat cDNA Microarray (G4105A)	701749110	-	-

Array Name	Probe IDs	Targets	Target Type
Affymetrix Rat Gene 1.0 ST Array	10758737	-	-
Affymetrix Rat Gene 1.0 ST Array	10758740	-	-
Affymetrix Rat Gene 1.0 ST Array	10758731	-	-
Affymetrix Rat Gene 1.0 ST Array	10758732	-	-
Affymetrix Rat Gene 1.0 ST Array	10758736	-	-
Affymetrix Rat Gene 1.0 ST Array	10758743	-	-
Affymetrix Rat Gene 1.0 ST Array	10758730	-	-
Affymetrix Rat Gene 1.0 ST Array	10758735	-	-
Affymetrix Rat Gene 1.0 ST Array	10758734	-	-
Affymetrix Rat Gene 1.0 ST Array	10758728	-	-
Affymetrix Rat Gene 1.0 ST Array	10758729	-	-
Affymetrix Rat Gene 1.0 ST Array	10758742	-	-
Affymetrix Rat Gene 1.0 ST Array	10758738	-	-
Affymetrix Rat Gene 1.0 ST Array	10758739	-	-
Affymetrix Rat Gene 1.0 ST Array	10758741	-	-
Affymetrix Rat Gene 1.0 ST Array	10758733	-	-
Affymetrix Rat Gene 1.1 ST Array	10758727	-	-
Affymetrix Rat Gene 1.1 ST Array	10758744	-	-
Rat Genome 230 2.0 Array	1388379_at	-	-
Rat Genome 230 2.0 Array	1387668_at	-	-
Rat Genome 230 2.0 Array	1387668_PM_at	-	-
Rat Genome 230 2.0 Array	1388379_PM_at	-	-
Affymetrix HT Rat Focus Array	1388379_PM_at	-	-
Affymetrix HT Rat Focus Array	1387668_at	-	-
Affymetrix HT Rat Focus Array	1387668_PM_at	-	-
Affymetrix HT Rat Focus Array	1388379_at	-	-
Affymetrix Rat Clariom S Assay	PSR1200006124.rn.1	TC1200000673.rn.1	RTA TC
Affymetrix Rat Clariom S Assay	PSR1200006123.rn.1	TC1200000673.rn.1	RTA TC
Affymetrix Rat Clariom S Assay	PSR1200006125.rn.1	TC1200000673.rn.1	RTA TC
Rat Expression Set 230	1387668_at	-	-
Rat Expression Set 230	1387668_PM_at	-	-
Rat Expression Set 230	1388379_PM_at	-	-
Rat Expression Set 230	1388379_at	-	-
Affymetrix Rat Gene 1.0 ST Array	10758727	-	-
Rat Genome U34 Set	rc_AI138070_at	-	-
Rat Genome U34 Set	U09307_at	-	-
Rat Genome U34 Set	rc_AI171525_at	-	-
Rat Genome U34 Set	U57499_at	-	-
Rat Genome U34 Set	U57499_g_at	-	-
Rat Genome U34 Set	rc_AI012725_s_at	-	-
Rat Genome U34 Set	rc_AI172465_at	-	-

Array Name	Probe IDs	Targets	Target Type
ABI Rat Genome Survey Microarray	21382371	-	-

Array Name	Probe IDs	Targets	Target Type
Illumina ratRef-12 v1.0 expression beadchip	ILMN_1363069	-	-
RatRef-12 Expression BeadChip	ILMN_64422	-	-