114414

• Gene Symbol: NKX2-5
• Gene Name: NK2 homeobox 5
• Gene Aliases: CHNG5, CSX, CSX1, HLHS2, NKX2.5, NKX2E, NKX4-1, VSD3
• Chromosome Location: Chr.5: 173232104 - 173235312 on Build GRCh38
• UniGene ID: Hs.54473
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: NKX2-5
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001166175.1	NP_001159647.1	2	1895
	NM_001166176.1	NP_001159648.1	2	1858
	NM_004387.3	NP_004378.1	2	1603
GenBank mRNA	BC025711.1	-	2	1481	5225103
	U34962.1	-	2	1550

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_008700, X75415, AK142146.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
heart looping
heart morphogenesis
outflow tract septum morphogenesis
cardiac conduction system development
bundle of His development
Purkinje myocyte differentiation
cardiac ventricle formation
right ventricular cardiac muscle tissue morphogenesis
ventricular trabecula myocardium morphogenesis
apoptotic process involved in heart morphogenesis
septum secundum development
proepicardium development
pulmonary myocardium development
transcription from RNA polymerase II promoter
adult heart development
positive regulation of cell proliferation
negative regulation of cardiac muscle cell apoptotic process
positive regulation of transcription via serum response element binding
positive regulation of sodium ion transport
negative regulation of myotube differentiation
hemopoiesis
cell differentiation
BMP signaling pathway
thyroid gland development
embryonic heart tube development
negative regulation of apoptotic process
sarcomere organization
positive regulation of neuron differentiation
positive regulation of heart contraction
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
positive regulation of cardioblast differentiation
ventricular cardiac myofibril assembly
cardiac muscle cell differentiation
cardiac muscle tissue morphogenesis
atrial cardiac muscle cell development
ventricular cardiac muscle cell development
regulation of cardiac muscle contraction
pharyngeal system development
cardiac muscle cell proliferation
regulation of cardiac muscle cell proliferation
cardiac muscle contraction
canonical Wnt signaling pathway
positive regulation of transcription initiation from RNA polymerase II promoter
heart trabecula formation
ventricular septum morphogenesis
atrial septum morphogenesis
atrioventricular node cell development
atrioventricular node cell fate commitment
embryonic heart tube left/right pattern formation
negative regulation of canonical Wnt signaling pathway
regulation of cardiac conduction

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription cofactor activity
transcriptional activator activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
serum response element binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity