121445

• Gene Symbol: AXIN1
• Gene Name: axin 1
• Gene Aliases: AXIN, PPP1R49
• Chromosome Location: Chr.16: 287440 - 355226 on Build GRCh38
• UniGene ID: Hs.592082
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: AXIN1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_003502.3	NP_003493.1	2	824
	NM_181050.2	NP_851393.1	2	824
	NR_134879.1		2	824
	XM_011522682.2	XP_011520984.1	2	835
	XM_011522683.2	XP_011520985.1	2	834
	XM_011522684.2	XP_011520986.1	2	685
	XM_017023743.1	XP_016879232.1	2	835
	XM_017023744.1	XP_016879233.1	2	834
	XM_017023747.1	XP_016879236.1	2	837
	XM_017023748.1	XP_016879237.1	2	837
GenBank mRNA	AF009674.1	-	2	547
	BC044648.1	-	2	596	5809104
	KF615850.1	-	2	824
	KF615851.1	-	2	824
	KF615852.1	-	2	824
	KU178413.1	-	1	435
	KU178414.1	-	1	435
	KU178415.1	-	1	435

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_024405, AF017756.
This siRNA also targets the following transcripts in Mouse: NM_009733, NM_001159598, AF009011, BC011544, BC113171.

Gene Ontology Categories:

Process(es)

optic placode formation
positive regulation of protein phosphorylation
apoptotic process
activation of JUN kinase activity
determination of left/right symmetry
cell death
dorsal/ventral axis specification
positive regulation of peptidyl-threonine phosphorylation
Wnt signaling pathway
forebrain anterior/posterior pattern specification
Wnt-activated signaling pathway involved in forebrain neuron fate commitment
negative regulation of Wnt signaling pathway
olfactory placode formation
cytoplasmic microtubule organization
positive regulation of protein ubiquitination
activation of protein kinase activity
positive regulation of peptidyl-serine phosphorylation
negative regulation of transcription elongation from RNA polymerase II promoter
regulation of catenin import into nucleus
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of GTPase activity
cellular protein complex assembly
negative regulation of fat cell differentiation
positive regulation of protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
embryonic eye morphogenesis
axial mesoderm formation
positive regulation of ubiquitin-protein transferase activity
muscle cell development
canonical Wnt signaling pathway
embryonic skeletal joint morphogenesis
canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
cellular response to organic cyclic compound
negative regulation of canonical Wnt signaling pathway
Wnt signaling pathway involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Function(s)

signal transducer activity
GTPase activator activity
protein binding
beta-catenin binding
enzyme binding
protein kinase binding
receptor signaling complex scaffold activity
ubiquitin protein ligase binding
protein complex scaffold
identical protein binding
protein homodimerization activity
SMAD binding
armadillo repeat domain binding
I-SMAD binding