130309

• Gene Symbol: NOD2
• Gene Name: nucleotide binding oligomerization domain containing 2
• Gene Aliases: ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
• Chromosome Location: Chr.16: 50693581 - 50733077 on Build GRCh38
• UniGene ID: Hs.592072
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: NOD2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001293557.1	NP_001280486.1	2	647
	NM_022162.2	NP_071445.1	3	687
	XM_005256084.3	XP_005256141.1	3	591
	XM_006721242.3	XP_006721305.1	3	591
	XM_006721243.3	XP_006721306.1	3	591
	XM_011523260.2	XP_011521562.1	3	591
	XM_011523261.1	XP_011521563.1	3	591
	XM_017023536.1	XP_016879025.1	2	118
	XM_017023538.1	XP_016879027.1	2	113
GenBank mRNA	AF178930.1	-	3	687
	AY187243.1	-	3	687
	AY187244.1	-	3	1409
	DQ868973.1	-	3	569
	HQ204571.1	-	3	569

More Information

Gene Ontology Categories:

Process(es)

activation of MAPK activity
cytokine production involved in immune response
cytokine secretion involved in immune response
positive regulation of dendritic cell antigen processing and presentation
positive regulation of type 2 immune response
defense response
JNK cascade
detection of biotic stimulus
detection of bacterium
maintenance of gastrointestinal epithelium
response to muramyl dipeptide
detection of muramyl dipeptide
positive regulation of interleukin-1 beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-17 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of stress-activated MAPK cascade
activation of MAPK activity involved in innate immune response
intracellular signal transduction
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
positive regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of gamma-delta T cell activation
positive regulation of epithelial cell proliferation
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
positive regulation of B cell activation
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
positive regulation of oxidoreductase activity
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of prostaglandin-endoperoxide synthase activity
positive regulation of ERK1 and ERK2 cascade
nucleotide-binding oligomerization domain containing signaling pathway
nucleotide-binding oligomerization domain containing 2 signaling pathway
cellular response to muramyl dipeptide
positive regulation of cytokine production involved in inflammatory response
positive regulation of NIK/NF-kappaB signaling
negative regulation of macrophage apoptotic process
positive regulation of prostaglandin-E synthase activity

Function(s)

actin binding
protein binding
ATP binding
enzyme binding
protein kinase binding
Hsp70 protein binding
muramyl dipeptide binding
peptidoglycan binding
CARD domain binding
Hsp90 protein binding