143747

• Gene Symbol: PDGFA
• Gene Name: platelet derived growth factor subunit A
• Gene Aliases: PDGF-A, PDGF1
• Chromosome Location: Chr.7: 497245 - 520668 on Build GRCh38
• UniGene ID: Hs.535898
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PDGFA
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002607.5	NP_002598.4	4	1147
	NM_033023.4	NP_148983.1	4	1147
	XM_011515415.1	XP_011513717.1	5	639
	XM_011515416.1	XP_011513718.1	5	643
	XM_011515417.1	XP_011513719.1	5	639
	XM_011515418.1	XP_011513720.1	5	643
	XM_011515419.2	XP_011513721.1	4	347
	XM_017012289.1	XP_016867778.1	4	380
GenBank mRNA	A09204.1	-	4	340
	AB451309.1	-	4	304
	AB451439.1	-	4	304
	AK292217.1	-	4	518
	AU118732.1	-	4	475
	BC109246.1	-	2	1167
	X03795.1	-	4	691
	X06374.1	-	4	707

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012801, XM_008768940, XM_006248919, XM_006248918, Z14120, and others.
This siRNA also targets the following transcripts in Mouse: NM_008808, BC003817, AY324648, AK017169, M29464.

Gene Ontology Categories:

Process(es)

MAPK cascade
angiogenesis
response to hypoxia
cell activation
hair follicle development
positive regulation of mesenchymal cell proliferation
platelet degranulation
transforming growth factor beta receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
response to wounding
organ morphogenesis
response to inorganic substance
negative regulation of phosphatidylinositol biosynthetic process
negative regulation of platelet activation
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of smooth muscle cell migration
cell projection assembly
actin cytoskeleton organization
extracellular matrix organization
positive regulation of cell migration
positive regulation of protein autophosphorylation
response to estradiol
response to retinoic acid
regulation of actin cytoskeleton organization
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
wound healing
response to drug
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of GTPase activity
skin development
positive regulation of DNA replication
phosphatidylinositol phosphorylation
platelet-derived growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
lung alveolus development
inner ear development
regulation of peptidyl-tyrosine phosphorylation
negative chemotaxis
positive regulation of cell division
positive regulation of protein kinase B signaling
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
positive regulation of ERK1 and ERK2 cascade
regulation of glomerular mesangial cell proliferation
embryonic lung development
regulation of DNA biosynthetic process

Function(s)

Ras guanyl-nucleotide exchange factor activity
platelet-derived growth factor receptor binding
protein binding
collagen binding
growth factor activity
protein homodimerization activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
platelet-derived growth factor binding