143749

• Gene Symbol: PDGFB
• Gene Name: platelet derived growth factor subunit B
• Gene Aliases: IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis
• Chromosome Location: Chr.22: 39223359 - 39245055 on Build GRCh38
• UniGene ID: Hs.1976
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PDGFB
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002608.3	NP_002599.1	7	2790
	NM_033016.3	NP_148937.1	7	1690
GenBank mRNA	AK022920.1	-	1	894
	BC029822.1	-	7	2010	5174750
	M12783.1	-	7	2788
	M32009.1	-	1	693
	X02744.1	-	7	1816
	X03702.1	-	6	1626

More Information

Gene Ontology Categories:

Process(es)

MAPK cascade
response to hypoxia
embryonic placenta development
positive regulation of endothelial cell proliferation
monocyte chemotaxis
platelet degranulation
positive regulation of glomerular filtration
DNA replication
protein phosphorylation
transforming growth factor beta receptor signaling pathway
heart development
positive regulation of cell proliferation
response to wounding
negative regulation of phosphatidylinositol biosynthetic process
negative regulation of platelet activation
positive regulation of gene expression
negative regulation of gene expression
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of smooth muscle cell migration
cell growth
peptidyl-serine phosphorylation
peptidyl-tyrosine phosphorylation
hemopoiesis
extracellular matrix organization
positive regulation of cell migration
positive regulation of protein autophosphorylation
negative regulation of protein binding
activation of protein kinase activity
activation of protein kinase B activity
response to estradiol
response to insulin
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
paracrine signaling
wound healing
response to drug
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of blood vessel endothelial cell migration
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
response to estrogen
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of DNA replication
positive regulation of mitotic nuclear division
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
phosphatidylinositol phosphorylation
platelet-derived growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
positive regulation of chemotaxis
positive regulation of cell division
cell chemotaxis
positive regulation of protein tyrosine kinase activity
positive regulation of ERK1 and ERK2 cascade
protein kinase C signaling
cellular response to growth factor stimulus
cellular response to mycophenolic acid
positive regulation of glomerular mesangial cell proliferation
metanephric glomerular mesangial cell development
reactive oxygen species metabolic process
positive regulation of calcium ion import
positive regulation of hyaluronan biosynthetic process
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of vascular smooth muscle cell proliferation
positive regulation of vascular associated smooth muscle cell migration
negative regulation of vascular smooth muscle cell differentiation
positive regulation of vascular smooth muscle cell dedifferentiation
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
positive regulation of metanephric mesenchymal cell migration

Function(s)

Ras guanyl-nucleotide exchange factor activity
platelet-derived growth factor receptor binding
protein binding
collagen binding
growth factor activity
superoxide-generating NADPH oxidase activator activity
chemoattractant activity
identical protein binding
protein homodimerization activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
platelet-derived growth factor binding