155888

• Gene Symbol: Insr
• Gene Name: insulin receptor
• Gene Aliases: 4932439J01Rik, CD220, D630014A15Rik, IR, IR-A, IR-B
• Chromosome Location: Chr.8: 3150922 - 3279649 on Build GRCm38
• UniGene ID: Mm.268003
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Insr
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_010568.2	NP_034698.2	5	1649
GenBank mRNA	J05149.1	-	5	1208
	KC356871.1	-	5	1160

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_017071, XM_006248753, XM_006248752, KF112847, KF112848, and others.

Gene Ontology Categories:

Process(es)

activation of MAPK activity
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
heart morphogenesis
regulation of transcription, DNA-templated
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
insulin receptor signaling pathway
epidermis development
organ morphogenesis
regulation of hydrogen peroxide metabolic process
positive regulation of glycoprotein biosynthetic process
negative regulation of gene expression
phosphorylation
peptidyl-tyrosine phosphorylation
transformation of host cell by virus
signal transduction by protein phosphorylation
male sex determination
positive regulation of cell migration
exocrine pancreas development
activation of protein kinase activity
activation of protein kinase B activity
negative regulation of transporter activity
cellular response to insulin stimulus
response to tumor necrosis factor
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
positive regulation of phosphorylation
glucose homeostasis
positive regulation of MAPK cascade
positive regulation of nitric oxide biosynthetic process
positive regulation of glycogen biosynthetic process
positive regulation of DNA replication
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
regulation of embryonic development
positive regulation of glucose import
protein autophosphorylation
positive regulation of developmental growth
protein heterotetramerization
positive regulation of protein kinase B signaling
positive regulation of respiratory burst
cellular response to growth factor stimulus

Function(s)

nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
insulin-activated receptor activity
insulin-like growth factor receptor binding
protein binding
ATP binding
GTP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
protein phosphatase binding
protein domain specific binding
lipoic acid binding
insulin-like growth factor I binding
insulin-like growth factor II binding
protein complex binding
3-phosphoinositide-dependent protein kinase binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin receptor substrate binding
PTB domain binding