1571

• Gene Symbol: CHEK2
• Gene Name: checkpoint kinase 2
• Gene Aliases: CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1
• Chromosome Location: Chr.22: 28687743 - 28741866 on Build GRCh38
• UniGene ID: Hs.291363
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: CHEK2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001005735.1	NP_001005735.1	2	380
	NM_001257387.1	NP_001244316.1	2	380
	NM_007194.3	NP_009125.1	2	380
	NM_145862.2	NP_665861.1	2	380
	XM_011529839.2	XP_011528141.1	2	402
	XM_011529840.2	XP_011528142.1	2	404
	XM_011529841.1	XP_011528143.1	2	384
	XM_011529842.2	XP_011528144.1	2	401
	XM_011529843.1	XP_011528145.1	2	380
	XM_011529844.2	XP_011528146.1	2	412
	XM_017028560.1	XP_016884049.1	2	402
GenBank mRNA	AB040105.1	-	1	308
	AF086904.1	-	1	308
	AF096279.1	-	1	308
	AF174135.1	-	1	308
	AF217975.1	-	2	979
	AJ131197.1	-	1	308
	AJ783839.1	-	1	308
	AK289360.1	-	2	359
	AK290754.1	-	2	382
	AY551296.1	-	1	308
	AY551297.1	-	1	308
	AY551298.1	-	1	308
	AY551299.1	-	1	308
	AY551300.1	-	1	308
	AY551301.1	-	1	308
	AY551302.1	-	1	308
	AY551303.1	-	1	308
	AY551304.1	-	1	308
	AY551305.1	-	1	308
	BC004207.2	-	2	335	3532866
	BM838597.1	-	2	380
	CR456418.1	-	2	379

More Information

Additional Information:

This siRNA no longer meets our design criteria. We suggest you choose a different siRNA for this gene or contact Tech Support for more information.

Gene Ontology Categories:

Process(es)

DNA damage checkpoint
G2/M transition of mitotic cell cycle
replicative cell aging
positive regulation of protein phosphorylation
double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
cellular response to DNA damage stimulus
DNA damage induced protein phosphorylation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intrinsic apoptotic signaling pathway in response to DNA damage
response to gamma radiation
peptidyl-serine phosphorylation
cellular response to drug
regulation of protein catabolic process
signal transduction in response to DNA damage
cellular protein catabolic process
positive regulation of transcription, DNA-templated
protein autophosphorylation
protein stabilization
cell division
negative regulation of cell cycle arrest
signal transduction involved in intra-S DNA damage checkpoint
mitotic spindle assembly
replicative senescence
regulation of signal transduction by p53 class mediator
response to doxorubicin
cellular response to bisphenol A
negative regulation of DNA damage checkpoint
positive regulation of anoikis

Function(s)

protein serine/threonine kinase activity
protein binding
ATP binding
protein kinase binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
metal ion binding