173425

• Gene Symbol: Dicer1
• Gene Name: dicer 1, ribonuclease type III
• Gene Aliases: 1110006F08Rik, D12Ertd7e, mKIAA0928
• Chromosome Location: Chr.12: 104687740 - 104751952 on Build GRCm38
• UniGene ID: Mm.21135
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Dicer1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_148948.2	NP_683750.2	4, 5	695
GenBank mRNA	AB081470.1	-	3, 4	493
	AF430845.1	-	4, 5	703
	AK035253.1	-	1, 2	40
	BC019805.1	-	4, 5	694
	BC061198.1	-	5, 6	643

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_030621, NM_001271282, NM_001195573, NM_177438, AB028449, and others.
This siRNA also targets the following transcripts in Rat: XM_008764904.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
meiotic spindle organization
angiogenesis
regulation of protein phosphorylation
hair follicle development
apoptotic DNA fragmentation
RNA processing
cell proliferation
regulation of Notch signaling pathway
post-embryonic development
zygote asymmetric cell division
regulation of gene expression
negative regulation of Schwann cell proliferation
positive regulation of gene expression
regulation of muscle cell apoptotic process
positive regulation of Schwann cell differentiation
myoblast differentiation involved in skeletal muscle regeneration
rRNA catabolic process
stem cell population maintenance
spinal cord motor neuron differentiation
nerve development
olfactory bulb interneuron differentiation
cerebral cortex development
lung development
embryonic limb morphogenesis
production of siRNA involved in RNA interference
targeting of mRNA for destruction involved in RNA interference
gene silencing by RNA
pre-miRNA processing
hair follicle morphogenesis
regulation of myelination
positive regulation of myelination
peripheral nervous system myelin formation
conversion of ds siRNA to ss siRNA involved in RNA interference
siRNA loading onto RISC involved in RNA interference
embryonic hindlimb morphogenesis
production of miRNAs involved in gene silencing by miRNA
multicellular organism growth
miRNA loading onto RISC involved in gene silencing by miRNA
conversion of ds siRNA to ss siRNA
regulation of odontogenesis of dentin-containing tooth
regulation of viral genome replication
regulation of cell differentiation
regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
mRNA stabilization
spleen development
digestive tract development
reproductive structure development
regulation of oligodendrocyte differentiation
epidermis morphogenesis
branching morphogenesis of an epithelial tube
neuron projection morphogenesis
anatomical structure development
regulation of neurogenesis
cartilage development
spindle assembly
regulation of RNA metabolic process
defense response to virus
regulation of cell cycle
cardiac muscle cell development
inner ear receptor cell development
negative regulation of glial cell proliferation
intestinal epithelial cell development
cardiac neural crest cell development involved in outflow tract morphogenesis
ganglion development
regulation of enamel mineralization
hair follicle cell proliferation
RNA phosphodiester bond hydrolysis
RNA phosphodiester bond hydrolysis, endonucleolytic
regulation of miRNA metabolic process
positive regulation of miRNA metabolic process

Function(s)

nucleotide binding
nucleic acid binding
RNA binding
double-stranded RNA binding
helicase activity
nuclease activity
endonuclease activity
endoribonuclease activity
ribonuclease III activity
deoxyribonuclease I activity
protein binding
ATP binding
hydrolase activity
endoribonuclease activity, producing 5'-phosphomonoesters
protein domain specific binding
siRNA binding
miRNA binding
metal ion binding
pre-miRNA binding