187280

• Gene Symbol: Tgfb1
• Gene Name: transforming growth factor, beta 1
• Gene Aliases: TGF-beta1, TGFbeta1, Tgfb, Tgfb-1
• Chromosome Location: Chr.7: 25687002 - 25704996 on Build GRCm38
• UniGene ID: Mm.248380
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tgfb1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_011577.1	NP_035707.1	3, 4	1502
GenBank mRNA	AJ009862.1	-	3, 4	1502
	AK144163.1	-	3, 4	1504
	BC013738.1	-	3, 4	949	3586216
	M13177.1	-	3, 4	987

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_021578, AY550025, BC076380, X52498.

Gene Ontology Categories:

Process(es)

protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
skeletal system development
morphogenesis of a branching structure
cell activation
epithelial to mesenchymal transition
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
regulation of sodium ion transport
chondrocyte differentiation
hematopoietic progenitor cell differentiation
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
tolerance induction to self antigen
protein phosphorylation
protein export from nucleus
ATP biosynthetic process
phosphate-containing compound metabolic process
cellular calcium ion homeostasis
defense response
inflammatory response
cell cycle arrest
mitotic cell cycle checkpoint
epidermal growth factor receptor signaling pathway
transforming growth factor beta receptor signaling pathway
common-partner SMAD protein phosphorylation
SMAD protein complex assembly
SMAD protein import into nucleus
Notch signaling pathway
negative regulation of neuroblast proliferation
endoderm development
skeletal muscle tissue development
negative regulation of DNA replication
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
germ cell migration
defense response to fungus, incompatible interaction
organ morphogenesis
response to organic substance
regulation of gene expression
positive regulation of gene expression
negative regulation of gene expression
positive regulation of epithelial to mesenchymal transition
positive regulation of fibroblast migration
positive regulation of peptidyl-threonine phosphorylation
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of macrophage cytokine production
cell growth
regulation of striated muscle tissue development
regulation of transforming growth factor beta receptor signaling pathway
evasion or tolerance of host defenses by virus
negative regulation of cell-cell adhesion
hyaluronan catabolic process
T cell differentiation
negative regulation of ossification
negative regulation of cell growth
positive regulation of cell migration
mammary gland development
positive regulation of histone deacetylation
organ regeneration
positive regulation of protein complex assembly
positive regulation of exit from mitosis
lipopolysaccharide-mediated signaling pathway
positive regulation of cellular protein metabolic process
response to estradiol
response to progesterone
regulation of interleukin-23 production
negative regulation of interleukin-17 production
positive regulation of interleukin-17 production
receptor catabolic process
regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of superoxide anion generation
mononuclear cell proliferation
positive regulation of collagen biosynthetic process
positive regulation of peptidyl-serine phosphorylation
positive regulation of histone acetylation
positive regulation of protein dephosphorylation
growth
wound healing
T cell activation
regulation of cell proliferation
negative regulation of T cell proliferation
regulation of protein import into nucleus
positive regulation of protein import into nucleus
positive regulation of odontogenesis
myelination
regulation of apoptotic process
myeloid dendritic cell differentiation
T cell homeostasis
positive regulation of apoptotic process
positive regulation of MAP kinase activity
regulation of MAPK cascade
protein kinase B signaling
positive regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase activity
regulatory T cell differentiation
cell-cell junction organization
negative regulation of fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
positive regulation of isotype switching to IgA isotypes
cell development
lymph node development
negative regulation of skeletal muscle tissue development
positive regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
positive regulation of protein secretion
negative regulation of phagocytosis
negative regulation of immune response
negative regulation of T cell activation
positive regulation of chemotaxis
positive regulation of NF-kappaB transcription factor activity
regulation of binding
regulation of DNA binding
positive regulation of smooth muscle cell differentiation
negative regulation of release of sequestered calcium ion into cytosol
positive regulation of cell division
positive regulation of protein kinase B signaling
pathway-restricted SMAD protein phosphorylation
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
mammary gland branching involved in thelarche
branch elongation involved in mammary gland duct branching
regulation of branching involved in mammary gland duct morphogenesis
negative regulation of gene silencing by miRNA
regulation of cartilage development
lens fiber cell differentiation
response to cholesterol
positive regulation of cell cycle arrest
cellular response to growth factor stimulus
cellular response to organic cyclic compound
cellular response to dexamethasone stimulus
cellular response to transforming growth factor beta stimulus
T-helper 17 cell lineage commitment
extracellular matrix assembly
positive regulation of branching involved in ureteric bud morphogenesis
extrinsic apoptotic signaling pathway
negative regulation of hyaluronan biosynthetic process
positive regulation of protein localization to nucleus
positive regulation of NAD+ ADP-ribosyltransferase activity
regulation of actin cytoskeleton reorganization
positive regulation of transcription regulatory region DNA binding

Function(s)

glycoprotein binding
antigen binding
type II transforming growth factor beta receptor binding
cytokine activity
transforming growth factor beta receptor binding
protein binding
growth factor activity
enzyme binding
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
protein homodimerization activity
protein heterodimerization activity
protein N-terminus binding