187799

• Gene Symbol: Grem1
• Gene Name: gremlin 1
• Gene Aliases: Cktsf1b1, Drm, Grem, ld
• Chromosome Location: Chr.2: 113748674 - 113758788 on Build GRCm38
• UniGene ID: Mm.166318
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Grem1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_011824.4	NP_035954.1	2	437
GenBank mRNA	AF045801.1	-	1	278
	AF108189.1	-	1	347
	AK135022.1	-	2	472
	AK157793.1	-	2	438
	AK164871.1	-	2	438
	BC015293.1	-	2	407	4216669

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_019282, Y10019.

Gene Ontology Categories:

Process(es)

cell morphogenesis
angiogenesis
branching involved in ureteric bud morphogenesis
cell migration involved in sprouting angiogenesis
positive regulation of receptor internalization
negative regulation of leukocyte chemotaxis
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
mesenchymal to epithelial transition involved in metanephros morphogenesis
signal transduction
activation of transmembrane receptor protein tyrosine kinase activity
cell-cell signaling
positive regulation of cell proliferation
organ morphogenesis
proximal/distal pattern formation
regulation of epithelial to mesenchymal transition
collagen fibril organization
negative regulation of cell growth
embryonic limb morphogenesis
negative regulation of bone mineralization
negative regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
regulation of stress-activated MAPK cascade
negative regulation of osteoblast proliferation
positive regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
endothelial cell migration
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of bone remodeling
determination of dorsal identity
positive regulation of NF-kappaB transcription factor activity
regulation of focal adhesion assembly
positive regulation of telomerase activity
limb development
negative regulation of pathway-restricted SMAD protein phosphorylation
ureteric bud formation
positive regulation of protein tyrosine kinase activity
signal transduction by p53 class mediator
negative regulation of monocyte chemotaxis
negative regulation of canonical Wnt signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of branching involved in ureteric bud morphogenesis
negative regulation of osteoclast proliferation
positive regulation of peptidyl-tyrosine autophosphorylation
negative regulation of bone trabecula formation
negative regulation of bone mineralization involved in bone maturation
positive regulation of receptor activity
positive regulation of cardiac muscle cell differentiation

Function(s)

cytokine activity
transmembrane receptor protein tyrosine kinase activator activity
vascular endothelial growth factor receptor 2 binding
heparan sulfate proteoglycan binding
receptor agonist activity