188356

• Gene Symbol: Tek
• Gene Name: endothelial-specific receptor tyrosine kinase
• Gene Aliases: AA517024, Cd202b, Hyk, STK1, Tie-2, Tie2
• Chromosome Location: Chr.4: 94739289 - 94874976 on Build GRCm38
• UniGene ID: Mm.14313
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tek
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001290549.1	NP_001277478.1	11	1847
	NM_001290551.1	NP_001277480.1	10	1694
	NM_013690.3	NP_038718.2	11	1847
GenBank mRNA	BC050824.1	-	10	1688	6333576
	D13738.1	-	11	1849
	S67051.1	-	12	1510
	X67553.1	-	11	1618
	X71426.1	-	12	1581

More Information

Gene Ontology Categories:

Process(es)

angiogenesis
patterning of blood vessels
vasculogenesis
positive regulation of protein phosphorylation
endothelial cell proliferation
regulation of endothelial cell proliferation
sprouting angiogenesis
positive regulation of cytokine secretion involved in immune response
protein phosphorylation
cell-matrix adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
heart development
positive regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
phosphorylation
single organismal cell-cell adhesion
negative regulation of angiogenesis
peptidyl-tyrosine phosphorylation
hemopoiesis
regulation of cell migration
positive regulation of vascular endothelial growth factor receptor signaling pathway
response to retinoic acid
regulation of establishment or maintenance of cell polarity
positive regulation of peptidyl-serine phosphorylation
substrate adhesion-dependent cell spreading
intracellular signal transduction
positive regulation of protein import into nucleus
negative regulation of apoptotic process
positive regulation of phosphatidylinositol 3-kinase activity
response to estrogen
regulation of angiogenesis
positive regulation of angiogenesis
positive regulation of cell adhesion
protein autophosphorylation
Tie signaling pathway
protein oligomerization
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
heart trabecula formation
positive regulation of ERK1 and ERK2 cascade
regulation of NIK/NF-kappaB signaling
positive regulation of intracellular signal transduction
positive regulation of actin cytoskeleton reorganization
negative regulation of endothelial cell apoptotic process

Function(s)

nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
growth factor binding