197066

• Gene Symbol: Bmp4
• Gene Name: bone morphogenetic protein 4
• Gene Aliases: BOMPR4A
• Chromosome Location: Chr.15: 20776060 - 20791014 on Build Rnor_6.0
• UniGene ID: Rn.10318
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Bmp4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_012827.2	NP_036959.2		586
	XM_006251746.2	XP_006251808.1		1348
	XM_006251747.2	XP_006251809.1		898
	XM_006251748.2	XP_006251810.1	4	880
	XM_006251749.2	XP_006251811.1		622
	XM_006251751.2	XP_006251813.1		599
	XM_008770501.1	XP_008768723.1		712
GenBank mRNA	AY184241.1	-	2	448
	BC078901.1	-		586	7121295
	Z22607.1	-	4	848

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_007554, X56848, AK136527, AK145359.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
activation of MAPKK activity
skeletal system development
angiogenesis
ovarian follicle development
blood vessel development
osteoblast differentiation
eye development
metanephros development
ureteric bud development
branching involved in ureteric bud morphogenesis
mesoderm formation
organ induction
kidney development
mesonephros development
neural tube closure
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
vasculature development
endochondral ossification
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
chondrocyte differentiation
hematopoietic progenitor cell differentiation
lymphoid progenitor cell differentiation
renal system process
BMP signaling pathway involved in heart induction
secondary heart field specification
type B pancreatic cell development
mesenchymal to epithelial transition involved in metanephros morphogenesis
common-partner SMAD protein phosphorylation
smoothened signaling pathway
germ cell development
brain development
mesoderm development
mesodermal cell fate determination
heart development
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
response to mechanical stimulus
post-embryonic development
tissue development
anterior/posterior axis specification
specification of organ position
regulation of cell fate commitment
regulation of gene expression
positive regulation of calcium ion transport into cytosol
positive regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of cell death
positive regulation of neuron projection development
response to organic cyclic compound
telencephalon development
dorsal/ventral neural tube patterning
telencephalon regionalization
pituitary gland development
erythrocyte differentiation
monocyte differentiation
macrophage differentiation
lung development
embryonic limb morphogenesis
positive regulation of bone mineralization
BMP signaling pathway
positive regulation of BMP signaling pathway
forebrain development
positive regulation of protein binding
negative regulation of chondrocyte differentiation
response to estradiol
response to retinoic acid
positive regulation of collagen biosynthetic process
negative regulation of T cell differentiation in thymus
negative regulation of immature T cell proliferation in thymus
response to testosterone
protein localization to nucleus
cellular response to oxidative stress
embryonic hindlimb morphogenesis
tendon cell differentiation
deltoid tuberosity development
growth
wound healing
regulation of protein import into nucleus
negative regulation of phosphorylation
odontogenesis of dentin-containing tooth
odontogenesis
regulation of odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
camera-type eye development
positive regulation of apoptotic process
negative regulation of apoptotic process
steroid hormone mediated signaling pathway
negative regulation of MAP kinase activity
tongue morphogenesis
cell fate commitment
regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of endothelial cell differentiation
positive regulation of epidermal cell differentiation
negative regulation of myoblast differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of ossification
negative regulation of cell cycle
negative regulation of mitotic nuclear division
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
mesodermal cell differentiation
intermediate mesodermal cell differentiation
camera-type eye morphogenesis
embryonic morphogenesis
anatomical structure formation involved in morphogenesis
regulation of smooth muscle cell proliferation
positive regulation of smooth muscle cell proliferation
neuron fate commitment
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
embryonic skeletal system development
negative regulation of oligodendrocyte differentiation
smooth muscle tissue development
branching morphogenesis of an epithelial tube
positive regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
positive chemotaxis
smooth muscle cell differentiation
regulation of smooth muscle cell differentiation
response to glucocorticoid
positive regulation of cardiac muscle fiber development
anatomical structure regression
retina development in camera-type eye
inner ear receptor cell differentiation
cloacal septation
lens induction in camera-type eye
embryonic skeletal joint morphogenesis
bone development
cranial suture morphogenesis
positive regulation of SMAD protein import into nucleus
regulation of pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
lung morphogenesis
epithelium development
bronchus development
trachea development
trachea formation
epithelial tube branching involved in lung morphogenesis
branching involved in prostate gland morphogenesis
bud elongation involved in lung branching
lung lobe development
epithelial cell proliferation involved in lung morphogenesis
bud dilation involved in lung branching
prostate gland morphogenesis
negative regulation of cell death
mammary gland formation
epithelial-mesenchymal cell signaling
negative regulation of prostatic bud formation
regulation of branching involved in prostate gland morphogenesis
regulation of morphogenesis of a branching structure
regulation of cartilage development
positive regulation of cartilage development
positive regulation of branching involved in lung morphogenesis
BMP signaling pathway involved in ureter morphogenesis
BMP signaling pathway involved in renal system segmentation
pulmonary artery endothelial tube morphogenesis
negative regulation of thymocyte apoptotic process
positive regulation of hepatocyte differentiation
regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
cellular response to mechanical stimulus
cellular response to growth factor stimulus
cellular response to dexamethasone stimulus
response to nitric oxide
cellular response to BMP stimulus
BMP signaling pathway involved in nephric duct formation
renal system development
glomerular visceral epithelial cell development
negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
glomerular capillary formation
negative regulation of glomerular mesangial cell proliferation
mesenchymal cell proliferation involved in ureteric bud development
mesenchymal cell differentiation involved in kidney development
ureter epithelial cell differentiation
ureter smooth muscle cell differentiation
mesenchymal cell proliferation involved in ureter development
negative regulation of mesenchymal cell proliferation involved in ureter development
metanephric collecting duct development
positive regulation of kidney development
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of branching involved in ureteric bud morphogenesis
negative regulation of glomerulus development
cellular response to thyroid hormone stimulus
positive regulation of store-operated calcium channel activity
positive regulation of mesenchymal stem cell proliferation
negative regulation of metanephric S-shaped body morphogenesis
negative regulation of metanephric comma-shaped body morphogenesis
positive regulation of DNA-dependent DNA replication
negative regulation of cell proliferation involved in heart morphogenesis
positive regulation of endothelial cell apoptotic process
mesenchymal cell differentiation involved in renal system development

Function(s)

cytokine activity
transforming growth factor beta receptor binding
growth factor activity
heparin binding
chemoattractant activity
protein homodimerization activity
BMP receptor binding